NFL Monday Night Football Odds | MNF Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Ah, Monday Night Football. Nothing is better than sitting on the couch after a long day of work and watching some football.

It’s a new product in 2022 as Joe Buck and Troy Aikman take over the ESPN broadcast, and several quality matchups are on the schedule. So what games should you already consider betting on this year?

Here are the current NFL Monday Night Football odds and lines for the 2022 season.

NFL Monday Night Football Odds & Lines

NFL Monday Night Football odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Friday, July 29 at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds as the season progresses.

NFL Monday Night Football Games

Week 1: Denver Broncos @ Seattle Seahawks

Broncos -4.5 (-110) @ Seahawks +4.5 (-110)

Russell Wilson‘s first game with the Broncos will be against his former team - the Seattle Seahawks. And not only is this game against the Seahawks, but it’s also in Seattle on Monday Night Football.

While the Seahawks will probably make this game competitive for a while, the talent differential is massive. Therefore, expect the Broncos to win by at least a touchdown and cover this spread. Back Denver as your NFL play of the day.

Sportsbook Play of the Day

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Week 2: Tennessee Titans @ Buffalo Bills (8:15 p.m. EST)

Titans +7 (+105) @ Bills -7 (-125)

The Titans were the No. 1 seed in the AFC last year due to a regular-season win over the Bills. Mike Vrabel’s team has had a lot of success against Buffalo and it wouldn’t be a surprise if they upset them again. Take the Titans as 7-point underdogs in this game despite being the far less talented team after beating them in back-to-back seasons.

Week 2: Minnesota Vikings @ Philadelphia Eagles (9:30 p.m. EST)

Vikings +2.5 (-110) @ Eagles -2.5 (-110)

This is an underrated contest in Week 2 as the Vikings and Eagles could be sleeper teams in the NFC. Betting on Kirk Cousins on the road in primetime is usually risky, but that’s the lean here as the Vikings should have a much more explosive offense in 2022.

It’s also worth mentioning that this is the second game of a doubleheader on Monday Night Football. Two games on a Monday? Sign us up.

Week 3: Dallas Cowboys @ New York Giants

Cowboys -4 (-110) @ Giants +4 (-110)

There is a lot not to like about the offseason for the Cowboys, but they have been great against the Giants over the past decade. Dak Prescott has won his last nine starts against the Giants and the outcome usually isn’t close.

Take the Cowboys to win and cover the four-point spread here in Week 3.

Week 4: Los Angeles Rams @ San Francisco 49ers

Rams -1 (-110) @ 49ers +1 (-110)

The Rams and the 49ers have produced some awesome games over the last few years, and they had another one in the NFC Championship Game. However, Kyle Shanahan has dominated Sean McVay during the regular season, going 7-3 in their last 10 meetings.

So, even though the Rams are the Super Bowl champions, take the 49ers here at home in this primetime contest.

Week 5: Las Vegas Raiders @ Kansas City Chiefs

Raiders +6 (-110) @ Chiefs -6 (-110)

Are the Raiders ready to take over the AFC West? If the answer is yes, they’ll need to be able to compete with the Chiefs in Kansas City. The Raiders beat them in 2020 but were blown out in their 2021 meeting.

While it’s fair to be excited about the Raiders in this game, take the Chiefs to win and cover the spread in Week 5.

Week 6: Denver Broncos @ Los Angeles Chargers

Broncos +3 (+100) @ Chargers -3 (-120)

Wilson vs. Justin Herbert in primetime? Sign me up. The Broncos are an incredibly talented team, but it will take them several weeks to get used to their new quarterback. And with this game being in Los Angeles, take the Chargers to win and cover.

Week 7: Chicago Bears @ New England Patriots

Bears +6 (-110) @ Patriots -6 (-110)

It’s the battle between two first-round quarterbacks from the 2021 draft, with Justin Fields taking on Mac Jones. That is easily the most exciting part of this matchup, as the Patriots should be able to shut down the offense for the Bears.

Take the Patriots to win and cover this spread in Foxboro.

Week 8: Cincinnati Bengals @ Cleveland Browns

Bengals N/A @ Browns N/A

Will Deshaun Watson be available for this game? It looks like yes, but if he is not, expect the Bengals to be three- or four-point favorites on the road in Cleveland.

Week 9: Baltimore Ravens @ New Orleans Saints

Ravens -1 (-110) @ Saints +1 (-110)

One of the most underrated games on the Monday Night Football schedule features the Ravens and the Saints. Both teams missed the playoffs in 2021, and that’s pretty uncommon for both franchises. The bet here is to take the Saints as home underdogs as their defense has the pieces to slow down Lamar Jackson and company.

This should be a highly entertaining game in the middle of the season.

Week 10: Washington Commanders @ Philadelphia Eagles

Commanders +3.5 (-110) @ Eagles -3.5 (-110)

Carson Wentz will finally get a chance to take on his former team in primetime. That seems like a disaster waiting to happen. With the Eagles having one of the best rosters in the NFL, take them to win and cover this spread against their division rival.

Week 11: San Francisco 49ers @ Arizona Cardinals

49ers -2 (-110) @ Cardinals +2 (-110) 

Both the 49ers and the Cardinals made the playoffs last year, but it was Arizona who completed the season-sweep against San Francisco. Don’t expect them to have the same luck this season as Trey Lance made his first start against the Cardinals last season.

Instead, take the 49ers as road favorites in this game and expect them to run all over the Cardinals here in Week 11.

Week 12: Pittsburgh Steelers @ Indianapolis Colts

Steelers +4.5 (-110) @ Colts -4.5 (-110)

Who will be starting at quarterback for the Steelers at this point in the season? If the answer is Kenny Pickett, don’t be surprised if this line moves to Colts -6 before kick-off. However, even if Mitchell Trubisky is under center, take the Colts -4.5 as they are just the more well-balanced team with a veteran quarterback in Matt Ryan.

Week 13: New Orleans Saints @ Tampa Bay Buccaneers

Saints +6.5 (-110) @ Buccaneers -6.5 (-110)

The Saints and Bucs played in primetime last year, and it was the Saints who shut out Tom Brady. Their defense has dominated Brady, beating him in all four regular-season games since he’s joined the Buccaneers.

Despite the Buccaneers being the more talented and Super Bowl-ready team, it’s hard to bet against the Saints here. And with New Orleans getting 6.5 points, bet them with confidence in this matchup.

Week 14: New England Patriots @ Arizona Cardinals

Patriots +2.5 (-110) @ Cardinals -2.5 (-110)

The Patriots and the Cardinals made the playoffs last season, but can they do it again in 2022? This could be a critical game late in the year for both teams but side with the Cardinals here as they are just so much more explosive on offense.

Week 15: Los Angeles Rams @ Green Bay Packers

Rams PICK (-110) @ Packers PICK (-110)

These are probably the best two teams in the NFC going into the year, as the Rams will look to defeat the Packers in Green Bay. A Week 15 matchup between Matthew Stafford and Aaron Rodgers will be must-see TV.

Stafford has never had a ton of luck in Lambeau, but the roster is incredibly talented around him. Take the Rams here as the defending Super Bowl champions should be able to put up a ton of points in this contest.

Week 16: Los Angeles Chargers @ Indianapolis Colts

Chargers -1 (-110) @ Colts +1 (-110)

Another fantastic contest here in Week 16, as the Chargers are slight road favorites over the Colts. Both teams have playoff aspirations and could be fighting for spots in the tournament heading into this matchup.

The Colts are a pretty good home team, but this is a game in which Herbert should shine. Take the Chargers and expect them to win and cover in this AFC matchup.

Week 17: Buffalo Bills @ Cincinnati Bengals

Bills PICK (-110) @ Bengals PICK (-110)

Could this be a preview of the AFC Championship Game? It very well could have been last year if the Bills were able to stop Patrick Mahomes and the Chiefs in the final 13 seconds of their playoff contest.

But enough about that game. What about this matchup?

Both teams have uber-talented quarterbacks and defenses that can hold their opponents down. But with this game being in Week 17, it’s more likely that the Bengals have something to play for than the Bills, who are in an easier division.

Take the Bengals to win this game outright and cover the spread.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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