NFL Thursday Night Football Odds | TNF Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Thursday Night Football has a new home this year as Amazon Prime will host the games. Their crew of Al Michaels and Kirk Herbstreit will provide a big-game feel for Thursday nights.

So what are the top games for Thursday Night Football this year?

Here are the latest NFL Thursday Night Football odds and lines for the 2022 season.

NFL Thursday Night Football Odds & Lines

NFL Thursday Night Football odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Thursday, July 28 at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds as the season progresses.

NFL Thursday Night Football Games

Week 2: Los Angeles Chargers @ Kansas City Chiefs

Chargers +3 (-110) @ Chiefs -3 (-110)

Arguably the best game of the year will happen in Week 2 as the Chargers will travel to Kansas City to take on the Chiefs. The Chargers upset the Chiefs on the road last year on Thursday night. Can they do it again?

Betting on the Chargers +3 while the Chiefs figure out their offense isn’t a bad idea. Back Los Angeles as your NFL pick of the day.

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Week 3: Pittsburgh Steelers @ Cleveland Browns

Steelers N/A @ Browns N/A

The Browns will likely start Jacoby Brissett in this game and the Steelers will go with Mitchell Trubisky. Yikes. But this should still be a fun defensive battle between two bitter rivals. Considering how well Mike Tomlin has done against Cleveland in the past, they are probably the better bet whenever the odds are released.

Week 4: Miami Dolphins @ Cincinnati Bengals 

Dolphins +4 (-110) @ Bengals -4 (-110)

Not many teams have the cornerbacks to match up against the trio of receivers that the Bengals can deploy. But Miami is loaded in the secondary with two Pro Bowl cornerbacks in Xavien Howard and Byron Jones. As long as the offense can score 21 or more points, Miami should be able to keep this one close.

Miami’s defense shouldn’t have any issues slowing down Cincinnati, so take the Dolphins at +4 here with confidence.

Week 5: Indianapolis Colts @ Denver Broncos

Colts +3 (-110) @ Broncos -3 (-110)

Both the Colts and the Broncos will have new starting quarterbacks this year, but this game should easily be won by the Broncos. Their defense should slow down the passing attack of Indianapolis and the Broncos’ offense should be able to put up points. Take the Broncos at -3 right now as that line will surely rise by kickoff.

Week 6: Washington Commanders @ Chicago Bears

Commanders -1.5 (-110) @ Bears +1.5 (-110)

One of the worst games of the Thursday Night slate features the Commanders and the Bears. Both teams are rebuilding, but the Commanders do have the better roster going into the season. Betting on Carson Wentz as a road favorite is always a little scary, but Washington does have the better team going into the year.

Week 7: New Orleans Saints @ Arizona Cardinals

Saints +3 (-110) @ Cardinals -3 (-110)

This is one of the more underrated games on the Thursday Night Football schedule as both the Saints and Cardinals believe they will be playoff teams in 2022. The Saints have one of the best defenses in the NFL, while the Cardinals are highly explosive on offense.

Take the Saints in this spot as they are getting three points and they should be able to slow down Kyler Murray and the rest of the offense. This will likely be a close game, which bodes well for Saints +3 bettors.

Week 8: Baltimore Ravens @ Tampa Bay Buccaneers

Ravens +3.5 (-110) @ Buccaneers -3.5 (-110)

The Ravens have historically played well against Tom Brady, but can they slow down Tampa Bay Tom? That is a different question.

The Ravens being a +3.5-point underdog here in Week 8 seems a bit excessive. We know they have one of the league’s best special teams units and they should have one of the NFL’s best defenses. Plus, Tampa Bay is one of the oldest teams in the league and that usually doesn’t translate to success in short weeks.

For all of those reasons, take the Ravens +3.5 here as this should be a fantastic game in the middle of the year.

Week 9: Philadelphia Eagles @ Houston Texans

Eagles -5.5 (-110) @ Texans +5.5 (-110)

This is one of the biggest spreads on the Thursday Night Football slate, and it’s not hard to understand why. The Eagles made it to the playoffs in Year 1 of their rebuild, and the roster appears ready to challenge the Cowboys for the top spot in the NFC East.

Meanwhile, the Texans are still in a complete rebuild and could be in contention for the No. 1 pick in 2023. Look for this game to be a blowout in favor of the Eagles. Take Philadelphia -5.5 before this line rises to double-digits before kickoff.

Week 10: Atlanta Falcons @ Carolina Panthers

Falcons +4.5 (+100) @ Panthers -4.5 (-120)

In an NFC South showdown, the Falcons and Panthers will likely be competing for the No. 3 spot in the NFC South. While each team has some exciting players on both sides of the ball, neither of these squads will be competing for a playoff spot.

It’s really hard to get a good betting read on these two teams considering the uncertainty at quarterback, so it’s best just to stay away until we get closer to the season.

Week 11: Tennessee Titans @ Green Bay Packers

Titans +4.5 (-110) @ Packers -4.5 (-110) 

This game features the two No. 1 seeds from last year, who both got knocked out of the playoffs at home in Round 2. However, the Packers appear to be a much better team going into the 2022 season despite the loss of Davante Adams. 

The Titans have been one of the NFL’s best road teams over the last few years, but they just don’t match up particularly well against the Packers. Aaron Rodgers should be able to throw all over their secondary, which is among the worst in the NFL.

Don’t be afraid to take the Packers here at -4.5 as this line could move up to 5 or 5.5 before kickoff.

Week 12: Thanksgiving

Week 13: Buffalo Bills @ New England Patriots

Bills -3 (-110) @ Patriots +3 (-110)

The Bills and Patriots played one of the most memorable games of the season last year as Mac Jones completed only one pass and the Patriots still got the win. However, the Bills got their revenge by blowing out the Patriots in the playoffs.

The Bills are the far superior team, but it’s never a good idea to bet against Bill Belichick at home. For that reason alone, take the Patriots at +3 as a home dog.

Week 14: Las Vegas Raiders @ Los Angeles Rams

Raiders +4 (-110) @ Rams -4 (-110)

Another incredible game will feature the new-look Raiders against the Super Bowl champion Los Angeles Rams. These are two of the most explosive offenses in the NFL and points will be scored early and often in this contest.

The Raiders have one of the league’s worst offensive lines and that spells trouble against the Rams. Look for Aaron Donald to take over and for the Rams to ultimately win and cover in this contest.

Week 15: San Francisco 49ers @ Seattle Seahawks

49ers -3 (-110) @ Seahawks +3 (-110)

The 49ers and Seahawks have had some incredible battles over the last decade, but this matchup loses a bit of its juice with Russell Wilson off to Denver. Take the 49ers -3 here as they are a legitimate Super Bowl contender, while the Seahawks could be competing for the No. 1 pick in the 2023 NFL Draft at this point.

Week 16: Jacksonville Jaguars @ New York Jets

Jaguars +2.5 (-110) @ Jets -2.5 (-110)

There aren’t many “bad" games on the Thursday Night Football schedule, but this one certainly qualifies. At least we will get to see the former No. 1 and No. 2 pick from the 2021 NFL Draft compete against each other to see how they have progressed in Year 2.

But in terms of a betting lean, it might be a good idea to pass on this one considering we have no idea what these two teams will look like during the 2022-2023 season.

Week 17: Dallas Cowboys @ Tennessee Titans

Cowboys +1.5 (-110) @ Titans -1.5 (-110)

The last Thursday Night Football game of the season will feature two playoff teams from a year ago with the Cowboys and Titans. Both teams won their division a year ago, but their rosters look significantly worse than at this time last year.

The Titans are the better-coached team and usually play well in December and January. The same can’t be said for the Cowboys, so take the Titans at -1.5 here in Week 17.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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