NFL Thanksgiving Odds 2022

Posted: Nov 21, 2022Last updated: Jan 3, 2023

Nothing says Thanksgiving Day like family, food, and an NFL triple-header.

This year’s slate offers up a trio of delicious contests, with plenty of betting value on the side. With some of the biggest NFL stars set to take the stage, including Josh Allen, Dak Prescott, and Justin Jefferson, you won’t want to miss out on what should be a great day of football.

Here are the current NFL betting lines for the 2022 Thanksgiving Day games.

Thanksgiving NFL Odds & Lines

Thanksgiving NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Nov. 21, at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 12.

Thanksgiving NFL Games

Buffalo Bills @ Detroit Lions (12:30 p.m. ET)

Bills -9.5 (-105) @ Lions +9.5 (-115)

As is tradition, the Lions will host the opening game of the day, welcoming Josh Allen and the Bills to Ford Field. This contest has shootout potential, as Buffalo boasts one of the best offenses in the NFL and Detroit has averaged 31.6 points per game on its home turf this season.

The Lions enter Thursday’s matchup on a three-game winning streak, but they have lost five straight on Thanksgiving Day. Their ability to run the ball against this Buffalo defense with the tandem of D’Andre Swift and Jamaal Williams, who combined for four touchdowns in Sunday’s win over the Giants, should keep this game relatively close.

As long as this spread stays at 8.5 or higher, I’m backing Detroit as my NFL pick of the day.

New York Giants @ Dallas Cowboys (4:30 p.m. ET)

Giants +8.5 (-114) @ Cowboys -8.5 (-106)

The second helping of Thanksgiving NFL action will see the Dallas Cowboys host the New York Giants in a crucial NFC East matchup. Dallas has won eight of its last nine home games against New York but has struggled recently in this showcase spot.

The Cowboys are 3-7 in their last 10 Thanksgiving Day games (all at home) and have allowed 35-plus points in defeats each of the last two years. This highly-praised Dallas defense should be much more effective against a New York offense that relies heavily on the two-man run game of Saquon Barkley and Daniel Jones.

Expect standout linebacker Micah Parsons to have another big day, and for Dak Prescott and the offense to have success against New York’s blitz-heavy defense.

New England Patriots @ Minnesota Vikings (8:20 p.m. ET)

Patriots +3 (-110) @ Vikings -3 (-110)

The final game of the day will see the first-place Minnesota Vikings take on the New England Patriots.

Minnesota won’t have to wait long for an opportunity to move past its 40-3 blowout loss to the Cowboys, while New England will look to continue its charge up the AFC standings after knocking off the rival Jets in a defensive slugfest Sunday in Foxborough.

Kirk Cousins has always struggled in primetime, and while I’m expecting a better effort from the Vikings offense on Thursday, I’ll take the points with the Patriots at +3 or better.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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