NFL Thanksgiving Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 3, 2022

For the past decade, the NFL has decided to bless us with three games on Thanksgiving Day. This year, the quality of Thanksgiving schedule does not look great as we currently have two games with spreads of a touchdown or more.

Still, there is some value to be had on a favorite and two underdogs going into Week 12. Here are the current lines for the 2022 Thanksgiving Day games and our favorite bets for each contest.

Thanksgiving NFL Odds & Lines

Thanksgiving NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Thursday, July 14 at 5 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 12.

Thanksgiving NFL Games

Buffalo Bills @ Detroit Lions (12:30 p.m. ET)

Bills -8 (-110) @ Lions +8 (-110)

The Lions could be better than expected this season and it wouldn’t be a surprise to see this line drop as the year goes on. Still, the Bills are among the best teams in the NFL, and it’s hard to see them not putting on a show on Thanksgiving.

Plus, it’s always a good idea to bet on the better quarterback in games like this, and there couldn’t be a bigger disparity at that position than Josh Allen vs Jared Goff.

Expect this game to be close for a while, but for the Bills to eventually win by double-digits on this primetime stage. Don’t be afraid to put down some early action on the Bills -8 here as your NFL pick of the day for Thanksgiving.

New York Giants @ Dallas Cowboys (4:30 p.m. ET)

Giants +7 (-110) @ Cowboys -7 (-110)

The Cowboys have historically matched up well with the Giants over the last decade. In fact, Dallas has won eight of its last nine home games against New York.

However, the Cowboys have not played well on Thanksgiving Day in several years. They are 3-7 straight up in their last 10 Thanksgiving Day games (all at home) and have allowed an average of 30.8 points per game.

While we have no idea what the Giants will look like this season, getting them at +7 against a team that typically doesn’t play well on Thanksgiving seems like a steal.

New England Patriots @ Minnesota Vikings (8:20 p.m. ET)

Patriots +1.5 (-110) @ Vikings -1.5 (-110)

No coach in NFL history has been better when it comes to playing games on short rest than Bill Belichick. He always has his team prepared, and the Patriots have been historically good on Thanksgiving whenever they’ve had the opportunity to play.

With the Patriots being a slight underdog in this game, taking them at +1.5 feels like the best bet here. New England was a playoff team last year and they should be even better this season with Mac Jones going into Year 2.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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