Champions League Predictions | Round of 16

Last Updated: Jan 4, 2024

After a thrilling group stage to the competition, the field of Champions League teams has been cut in half as we have reached the Round of 16.

Defending champions Manchester City should be fine as they take on FC Copenhagen, but there are some teams that could have a tougher time moving on.

The competition is as fierce as ever with plenty of favorites still alive, so let’s take a look at our UCL Round of 16 Best Bet.

UCL Round of 16 Odds

Use The Game Day’s soccer lines comparison tool for the latest UCL Winner Odds. Select “UCL" from the drop-down menu and search for your preferred matchup.

Champions League Round of 16 Best Bet

Inter Milan To Advance (-130)

DraftKings Sportsbook • WAGER: 1 unit

For my UCL best bet, we’re going to back Simone Inzaghi’s fantastic Inter Milan squad to get past Atletico Madrid and advance to the quarterfinal.

After making it to last year’s final, Inter haven’t really dominated in UCL, perhaps part of the reason for these reasonably-priced odds, but they also haven’t needed to. They were in position to advance after just four matchdays and limped to the finish with a pair of draws after that.

Domestically, however, they’ve been utterly fantastic. They’ve scored by far the most goals in Serie A, headlined by Lautaro Martinez’s efforts, and have allowed the fewest, thanks in large part to the resurgence of centerback Francesco Acerbi. The Nerazzuri have lost just once and have yet to truly separate from the pack in the Scudetto race, but all underlying metrics indicate that a breakaway should be coming before long.

Meanwhile, Atletico Madrid are probably being viewed a bit too favorably by the sportsbooks, based on these odds. While Inter have dominated a strong Serie A, Diego Simeone’s squad is falling behind in a profoundly weak La Liga. They coasted through a terribly weak UCL group and don’t have a truly scary forward outside of Antoine Griezmann.

Inzaghi’s defense should be able to at least limit the French star, while the Atletico defense hasn’t been quite what it was in seasons past. This team has quietly been one of Europe’s best, and should be able to make it past a group that has had more than its fair share of challenges.

Champions League Winner Prediction

Real Madrid (+550)

For in-depth analysis, head over to The Game Day’s Champions League Winner Odds page.


William Schwartz

As a former athlete and lifetime fan, sports have always been a huge part of my life. I've written about them for almost as long as I've been watching and playing them, from a blog I wrote with a friend in middle school, to journalism classes at the University of Michigan, to today. I hope to bring you entertaining coverage, strong analysis, and profitable betting picks on any and all sports, whether it's MLB baseball, college football, European soccer, or anything in between.

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