NFL Week 11 Best Bets | Predictions & Picks for NFL Week 11

Last Updated: Nov 19, 2021

We have officially passed the midway point of the season, and the race to make the playoffs is on.

Week 11 has several high-leverage games all weekend long that will help us get a better picture of what the playoffs may look like in 2021.

To get you prepared for the week ahead, here are our best bets and picks for Week 11 of the NFL season. Please note that all NFL gameday odds are current as of 3:00 p.m. ET on Friday, November 19.

Marcus Mosher’s Best Bets NFL Betting Record: 35-23

Green Bay Packers vs Minnesota Vikings Prediction

Aaron Rodgers wasn’t at his best in Week 10, as his Packers only scored 17 points. That wasn’t completely unexpected as Rodgers was cleared from COVID-19 on Saturday.

Despite not being able to participate in a single practice all week, Green Bay earned a double-digit win in a big NFC contest.

The Packers will now take on the Vikings in Minnesota in Week 11, but they are the far better team. With the No. 1 seed in the NFC in reach, don’t expect Green Bay to slip up here.

Packers vs Vikings Prediction: Packers 24, Vikings 20

Packers vs Vikings Best Bet: Packers -1 (-110) at TwinSpires

It’s actually shocking that the Packers are barely favored in this game.

Yes, they are on the road, but the Vikings just aren’t close to being as good as the Packers are this season. Green Bay is also an impressive 9-0 ATS in their last nine games and should have no problem winning by at least a field goal on Sunday.

Packers vs Vikings Best Bet: Under 49.5 (-110) at TwinSpires

As good as the Packers have been this season, their offense has not been lighting up the scoreboard. They are averaging under 22 points per game, which is ranking No. 19 in the NFL.

Meanwhile, Minnesota’s offense has been more prolific, averaging 24.6 points per game. This figures to be a low-scoring NFC North matchup in which both teams try to establish the run.

Take the Under here and look for this to be a 23-20 type of game in Minnesota.

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Arizona Cardinals vs Seattle Seahawks Prediction

Russell Wilson returned to the field for the Seahawks in Week 10, but it’ll take some time before he begins to look like himself again.

Wilson threw two interceptions in the loss, both of which were picked off in the end zone. The offense did not score a point against the Packers and totaled just 208 yards.

Heading into Week 11, the Seahawks must win this game to avoid going to 3-7 and being out of the NFC playoff hunt. With the unknown status of Kyler Murray and DeAndre Hopkins, the Seahawks are a good bet to win this game at home.

Expect Wilson to look much more crisp in Week 11 and for the Seahawks offense to look much better.

Cardinals vs Seahawks Prediction: Seahawks 23, Cardinals 21

Cardinals vs Seahawks Best Bet: Seahawks +2 (-113) at TwinSpires

It’s hard to take too much out of what we saw on Sunday from Wilson and the Seahawks. The offense looked clunky, and Wilson missed several throws.

With another full week of practice, it’s reasonable to expect Wilson to get back on track and for Seattle to expose the underwhelming secondary of the Cardinals. They should be able to win outright, but the 2-point cushion makes this an easy choice for our NFL bet of the day.

Cardinals vs Seahawks Best Bet: Under 50 (-109) at TwinSpires

If there is one reason to be encouraged about the Seahawks this year, it’s their defense. They have allowed just 20.7 points per game and have given up a total of 37 points over the last three weeks.

If Murray does play, that certainly changes things in this game. But if it is Colt McCoy under center again, consider this total to be a lock to go Under.

Pittsburgh Steelers vs Los Angeles Chargers Prediction

Both the Steelers and the Chargers have to be incredibly disappointed by their Week 10 performances.

The Steelers tied the Lions in one of the worst games of the season. Meanwhile, the Chargers lost by 10 at home to the Minnesota Vikings.

Neither team is playing well, but the Steelers do have a defense that is reliable and can create havoc in the backfield. This is likely to be another ugly game, but it’s a huge AFC matchup with big-time playoff implications.

Look for the Steelers to find a way to get a win in Los Angeles this week.

Steelers vs Chargers Prediction: Steelers 21, Chargers 20

Steelers vs Chargers Best Bet: Steelers +6 (-110) at TwinSpires

This is a home game for the Chargers, but you can expect the stadium to be filled with mostly Steelers fans. With Justin Herbert really struggling over the last month (6.64 yards per attempt), he could be in for a rough showing against Pittsburgh on Sunday night.

Look for this game to be close, but for the Steelers to keep it at least within a touchdown.

It also doesn’t hurt that Pittsburgh has one of the most reliable kickers in the NFL in Chris Boswell. That could be the difference between Pittsburgh covering and winning on the road.

We also know how good Mike Tomlin has been as an underdog in his career. This seems like a perfect spot for him and his Steelers in Week 11.

Steelers vs Chargers Best Bet: Under 47.5 (-110) at TwinSpires

The Steelers were without Ben Roethlisberger on Sunday and the offense continued to struggle, scoring just 16 points against the Lions. As a team, they are averaging only 19.7 points per game this season.

With how much Pittsburgh has struggled on offense this season and how well their defense has played, look for this to be a low-scoring contest in Los Angeles.

Don’t be surprised if the winner of this game doesn’t score more than 21 points. Take the Under in this game as both offenses will struggle to sustain long drives.

Thanks for reading our NFL Week 11 Best Bets! For more NFL betting tips, check out our NFL Week 11 Parlay Picks.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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