NFL Week 16 Injury Report | How Injuries Affect Week 16 Betting Picks

As the weather gets cooler and the holidays near, the stakes get higher each week in the NFL. What could be a simple knee sprain or hamstring tweak could mean the difference between preparing for deep playoff runs or draft boards.

What seemed like certain wins for a team one month ago is suddenly up in the air due to positive COVID tests and injuries, leaving the league with parity not seen in years.

Having a licensed physical therapist interpret the NFL Week 16 injury reports provides you with the information you won’t find anywhere else. It also helps you make clear-cut decisions on tight lines and take advantage of injury mismatches before the odds change.

Below are the top NFL Week 16 injuries to consider when placing your Week 16 NFL betting picks.

Please note that all NFL Week 16 odds and lines are current as of 10:30 a.m. ET on Thursday, December 23.

NFL Week 16 Injuries & Betting Tips

Chris Godwin, WR, Tampa Bay Buccaneers (Torn Right ACL, MCL)

Tampa Bay Buccaneers @ Carolina Panthers

Chris Godwin’s season and chance to play in a second Super Bowl ended Sunday night with a questionable hit to his right knee from Saints CB P.J. Williams. The hit came from low and outside, forcing the knee into a valgus and hyperextension position, causing the multi-ligament injury.

An example of MCL & ACL tears. Credit: MedicalNewsToday.com

For now, the Buccaneers losing Godwin hurts them long-term, but they’re also currently dealing with hamstring injuries to Leonard Fournette and Mike Evans.

The team signed veteran RB Le’Veon Bell to fill in for Fournette, and Evans will try to play despite being week-to-week. In addition, Levonte David is out with a foot sprain for the next several weeks.

Without most of his offensive weapons available, Tom Brady will have trouble moving the ball, similar to how he did against the New Orleans Saints.

The Buccaneers head to Carolina with both sides expected to have trouble producing points. My betting pick is 1 unit on the Under 44 (-110) at Caesars.

over-under

-110

Buccaneers @ Panthers: Under 44 Points

TB @ CAR | 12/26, 1:00 PM ET

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Teddy Bridgewater, QB, Denver Broncos (Concussion)

Denver Broncos @ Las Vegas Raiders

Teddy Bridgewater suffered a scary-looking concussion Sunday as he attempted to take off for a first down midway through the third quarter. He was tripped up by one Bengals defender before getting tackled by another, with their weight driving Bridgewater’s shoulder and head into the turf.

Bridgewater required a spine board to get off the field, which is standard protocol when there is a suspected neck injury. He was brought to the hospital for further evaluation before being released and entering the NFL concussion protocol.

This is Bridgewater’s second concussion this season, which makes a quick return very unlikely.

The Broncos are fighting for their playoff lives, but with Drew Lock under center, I don’t like their chances — especially with three consecutive division games to close out the season.

The line is incredibly close on this one per our NFL gameday odds, but Las Vegas appears to be the healthier team which makes my betting pick 1 unit on the Raiders to defeat the Broncos (-110) at Caesars.

moneyline

-110

Raiders To Defeat Broncos

DEN @ LV | 12/26, 4:25 PM ET

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Julio Jones, WR, Tennessee Titans (Hamstring Strain)

Tennessee Titans vs San Francisco 49ers

Julio Jones and hamstring injuries have been synonymous with each other over the last two seasons. This has robbed the elite wideout of meaningful production for the Titans this season, and Jones is another example of the injuries that have ravaged Tennessee.

Jones has already been on injured reserve this season with a hamstring injury, which means that if he was placed on injured reserve again, his season would end. If he does attempt to play, he will have difficulty running crisp routes and creating separation. He had a full practice Wednesday, but I strongly question his effectiveness.

Fortunately, AJ Brown has been designated to return from injured reserve following his chest injury, but he still may not be 100 percent.

The Titans are limping to the finish line and coming into a physical game against the 49ers, who are also clawing to stay relevant for the playoffs. This makes my betting pick 1 unit on the Over 44.5 (-110) at Caesars.

over-under

-110

49ers @ Titans: Over 44.5 Points

SF @ TEN | 12/23, 8:20 PM ET

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Julio Jones, WR, Tennessee Titans

A nagging hamstring injury kept Julio Jones from logging a single reception in the Titans’ loss to the Steelers in Week 15. (Image: USA TODAY Sports)


Damien Harris, RB, New England Patriots (Hamstring Strain)

New England Patriots vs Buffalo Bills

Damien Harris suffered a hamstring strain in the narrow win over the Buffalo Bills in Week 13 that forced him out of the Week 15 loss against the Colts. With a hamstring strain, Harris would demonstrate a loss of explosive power hitting the hole and be a step slower cutting and juking at the second level.

Harris could still suit up, but would not be as effective in the cold weather in Foxborough. In addition, Rhamondre Stevenson was not at practice Wednesday due to illness and Brandon Bolden is still working through a knee injury, leaving the running game a potential timeshare.

The Buffalo Bills were embarrassed on national television in the last matchup by a team that passed only three times. I expect the Bills to come out with a more aggressive game plan and leave nothing to chance.

The AFC East title is on the line in this one, and that makes my NFL bet of the day 2 units for the Bills to cover the spread +2.5 (-110) at Caesars.

spread

-110

Bills Cover +2.5 Spread @ Patriots

BUF @ NE | 12/26, 1:00 PM ET

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Joe Mixon, RB, Cincinnati Bengals (Left Ankle Sprain)

Cincinnati Bengals vs Baltimore Ravens

Joe Mixon suffered a left ankle sprain in the 15-10 win over the Denver Broncos Sunday that elicits worry for his availability. The mechanism isn’t clear by video, but this is certainly an injury that must be monitored as game time nears.

Mixon suffered a left ankle injury in Week 4 which led to decreased production in the Week 5 loss to the Green Bay Packers, and this injury could have a similar result in Week 16. Therefore, Samaje Perine could see more snaps with Mixon getting worked in here and there.

With Lamar Jackson’s ankle injury worse than initially thought as he works through a bone bruise, this potentially elevates Tyler Huntley to the starting role once again.

With both teams missing offensive weapons, this could be a defensive battle, which makes my betting pick 1 unit on the Under 45 (-110) at Caesars.

over-under

-110

Ravens @ Bengals: Under 45 Points

BAL @ CIN | 12/26, 1:00 PM ET

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Antonio Gibson, RB, Washington Football Team (Toe Injury)

Washington Football Team @ Dallas Cowboys

Antonio Gibson briefly left the game with a toe injury on Tuesday night against the Eagles but returned to finish the game. Head coach Ron Rivera noted that Gibson’s toe injury was very similar to the turf toe injury suffered last year.

I detailed Gibson’s turf toe injury heading into the season and did not believe it would be an issue. Even if it is the same toe injured, this was unlucky, and I do not believe his past injury contributed to this latest one.

Gibson may have trouble pushing off the affected foot and cutting coming out of the backfield. He does have the benefit of knowing how to manage the injury, but his workload may be reduced, giving snaps to dynamic rookie Jarrett Patterson.

I believe Gibson will attempt to play with the team still in playoff contention, but it may not make a difference.  This makes my betting pick 1 unit on the Cowboys to cover the spread -10.5 (-110) at Caesars.

spread

-110

Cowboys Cover -10.5 Spread vs Washington

WAS @ DAL | 12/26, 8:20 PM ET

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Other Week 16 Notable Injuries

  • The New York Giants announced WR Sterling Shepard tore his Achilles and QB Daniel Jones was shut down due to his lingering neck injury, sending both to injured reserve, ending their seasons.
  • Arizona Cardinals WR DeAndre Hopkins required surgery to repair his torn right MCL and is not expected to return to play until the NFC Championship game or the Super Bowl if they make it that far.
  • Las Vegas Raiders S Johnathan Abram suffered a dislocation of his left shoulder in Monday’s win over the Cleveland Browns. This is yet another recurrence of the injury that has plagued him for several seasons and will require season-ending surgery.
  • Browns DE Takkarist McKinley suffered a torn Achilles on Monday night, ending his season and making a return in Week 1 of 2022 questionable.
  • Pittsburgh Steelers TE Pat Freiermuth suffered his second concussion of the season and is not expected to be available for the Week 16 matchup against the Kansas City Chiefs.

Kyle’s Injury Report Betting Record: 48-33, +4.19 Units

Thanks for reading our NFL Week 16 Injury Report! For more NFL Week 16 betting tips, check out our NFL Week 16 Best Bets and NFL Week 16 Prop Bets

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Schedule & Odds

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page