Thursday Night Football Predictions Week 16 | TNF Picks & 49ers vs Titans Best Bets

The San Francisco 49ers will visit the Tennessee Titans in the NFL Week 16 edition of Thursday Night Football at 8:20 p.m. ET on the NFL Network.

Entering Week 16, the Titans and 49ers would both qualify for the NFL playoffs if the season ended today. However, while we are in December, there is still a lot of football left to play.

Although the upcoming Thursday Night Football game between the 49ers and Titans does not have direct playoff implications since they play in different conferences, neither team can afford to lose, as both teams sit just one game ahead of the chasing pack.

Thursday Night Football Prediction Week 16

The 49ers and Titans are two teams going in opposite directions. The 49ers are 5-2 in their past seven games following a sluggish start to the year while the Titans are 1-3 in their past four games after opening the season 8-2.

Injuries have played a significant role on either side. The 49ers suffered injuries to George Kittle and their backfield early on, but have since got back on track once their key assets began to get healthy and returned to the field.

Meanwhile, the Titans were more or less healthy in the first half of the season. However, they have since lost Derrick Henry and A.J. Brown, two of their best players on offense.

We know that when healthy, the 49ers are one of the best teams in the NFL. They have displayed that talent in the second half of 2021. However, for the Titans, they need to figure out how to win without their top rusher and wideout.

While Brown will be eligible to return from injured reserve for this Week 16 matchup against the 49ers, we don’t know if he will be healthy enough to do so. Brown is dealing with a chest injury.


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If the 49ers are going to win on TNF, the key to victory will fall on the arm of Jimmy Garoppolo. Although the 49ers drafted his heir-apparent, Trey Lance, in last April’s Draft, Garoppolo has not only remained healthy this season, but he is also playing some of the best football of his career down the stretch.

If Garoppolo continues to throw the ball effectively while limiting the giveaways, he will have no issues exploiting the Titans’ secondary, one of the worst defensive backfields in the NFL.

I can’t go on without mentioning the 49ers’ defense. San Francisco’s defense looked like a shell of itself in the first half of the year, but they have gotten back on track amidst their 5-2 run. They should have no issue containing a Titans’ offense snake-bitten by injury.

Once fueled by a superior rushing attack and an efficient passing game, Tennessee’s offense is one-dimensional, struggling to score against above-average defenses.

For a Titans victory, they must step up on defense, especially in their secondary. While they can stop the run, they may have difficulty doing so facing Kyle Shanahan’s elite rushing scheme. Starting running back Elijah Mitchell will miss his third straight game, however, which means Jeff Wilson Jr. will handle the bulk of the carries alongside versatile playmaker Deebo Samuel.

Offensively, Ryan Tannehill must step up. Sure, he played well against the Jaguars in Week 14, but let’s face it, they were a Jacksonville team in the midst of turmoil surrounding one of the worst head coaching hires in NFL history, Urban Meyer, who has since been shown the door.

In the previous two games against the Patriots and Texans — yes, the Texans — Tannehill could not get out of his own way. He led his offense to 13 points in each of those losses.

The Titans only managed to put 13 points once again last week against the Steelers, with Tannehill throwing for just 153 yards and an interception.

If you can read in between the lines, I am all-in on the 49ers on Thursday night.

TNF Week 16 Pick: 49ers 26, Titans 21


Thursday NFL Betting Trends for 2021

  • The Over is 6-11.
  • The Underdog is 7-10 against the spread.
  • The Favorite is 14-3 on the moneyline.
  • The Home Team is 7-10.

*Anthony Cervino is 30-18 on his NFL Best Bets for 2021 for The Game Day.


Thursday Night Football Best Bets Week 16

*NFL gameday odds and lines are current as of 10 AM ET on Thursday, December 23.

TNF Best Bet: 49ers -3 (-110) at Caesars

Wager: 4 Units

I am all-in on the 49ers on TNF. They are the superior football team right now. The 49ers are 5-2 in their past seven games. In four of those wins, they managed to score 30+ points. In the other, they scored 26.

The Titans don’t have enough on offense to keep up, especially facing a stingy 49ers defense. You can score on the 49ers’ defense, but I just don’t believe the Titans have enough firepower on offense to do so.

This is a 49ers’ defense that held the Rams and Jaguars to 10 points apiece in two of the aforementioned five wins.

spread

-110

49ers: Cover -3 Spread @ Titans

SF @ TEN | 12/23, 8:20 PM ET

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TNF Best Bet: OVER 44.5 Total Points (-110) at Caesars

Wager: 2 Units

I believe in the 49ers’ offense more so than Tennessee’s. However, the Titans are still fighting to hold on to first place in the AFC South. They will put up a fight and score enough points to keep the game close. What’s more, the Total is only set at 44.5 points. The 49ers have scored over 30 four times in their past seven games.

If the 49ers drop another 31 points on Thursday night, then we only need 14 from the Titans to cover this bet.

over-under

-110

49ers @ Titans: OVER 44.5 Points

SF @ TEN | 12/23, 8:20 PM ET

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TNF Best Bet: 49ers Moneyline (-160) at Caesars

Wager: 4 Units

This moneyline will likely be favorable enough to bet on its own without having to use it as a leg on a parlay to return solid value. I am all-in on the 49ers here.

moneyline

-160

49ers To Defeat Titans

SF @ TEN | 12/23, 8:20 PM ET

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Thanks for reading our NFL Week 16 TNF Predictions! For more NFL betting tips, check out our NFL Week 16 Best Bets and NFL Week 16 Prop Bets.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page