Cardinals Odds 2022 | Best Cardinals Spreads, Props, & More

Posted: Aug 17, 2022Last updated: Sep 1, 2022

Best Cardinals Betting Lines 2022

The Arizona Cardinals are starting to get a reputation for folding down the back half of the season under head coach Kliff Kingsbury and quarterback Kyler Murray.

Arizona was the last team with an undefeated record in 2021, starting the season 7-0. Murray sprained his ankle in a Week 8 loss to the Packers and the Cardinals hobbled the rest of the way, ending the regular season 11-6 and getting blown out by the Super Bowl-champion Rams in the Wild Card round.

That didn’t stop Murray from getting a massive five-year extension in the offseason, which will pay him upwards of $230 million. He’ll now  have his friend and college teammate, Marquise Brown, to throw to after Arizona traded for the former Ravens wideout during the NFL Draft. The duo played together at Oklahoma in 2018, when Murray won the Heisman Trophy and Brown was one of the best wideouts in the nation.

With star wideout DeAndre Hopkins suspended for the first six weeks of the season and Christian Kirk now in Jacksonville, the 2022 Cardinals will be relying on that duo to reignite their chemistry instantly as they try to keep pace with the Super Bowl champion Rams in their division and others in a weaker NFC.

Cardinals Futures Betting Odds

Note: These Cardinals futures bet odds are current as of Friday, Aug. 19, at 4 p.m. ET and courtesy of Caesars Sportsbook. You can find more odds at these US betting sites. But be careful, as many of these NFL futures odds might shift as we get closer to the 2022 NFL season.

  • Win Total: Over 9 (+120) / Under 9 (-140)
  • Make Playoffs: Yes (+105) / No (-125)
  • Win NFC West (+350)
  • Win NFC Championship (+1500)
  • Win Super Bowl 57 (+3500)

🏈 to place any of these Cardinals futures bets at Caesars Sportsbook.

Check out more Arizona Cardinals promos.

Cardinals Super Bowl 57 Odds

Cardinals To Win Super Bowl (+3500)

The Cardinals have the 15th-best odds (+3500) to win Super Bowl 57, having drifted back slightly from (+3000) at the beginning of the offseason.

Hopkins already had trouble staying on the field last season, missing three games with a hamstring injury and then was shut down in December with a sprained knee.

Arizona’s offense was a complete mess without Hopkins last season, as Kyler Murray and co. stumbled down the final stretch of the regular season and mustered just 183 total yards in their Wild Card loss to the Rams.

Cardinals NFC Championship Odds

Cardinals To Win NFC Championship (+1500) 

The Cardinals would be interesting as a longer shot to win the NFC, but they have the second-hardest schedule in the league per their opponents’ 2021 records. It’s hard to imagine this team starting things off on the right foot, especially after the collapse at the end of last season.

Add in the fact that the roster seemingly regressed a bit in the offseason, as RB Chase Edmonds, LB Jordan Hicks, and pass-rusher Chander Jones joined Christian Kirk in departing in free agency, and this team could be in some trouble.

While the NFC is pretty open and three teams from the NFC West made the playoffs last year, I could see teams like the Eagles, Vikings, and Saints closing the gap on the Cardinals.

If you believe in Arizona, wait until they start 1-2 or worse — their first three games are: Chiefs, @ Raiders, Rams — and then buy on a bigger number.

Cardinals NFC West Winner Odds

Cardinals to Win NFC West Championship (+350)

There are questions about every team in this division, but Arizona’s path to winning the West isn’t easy.

The Cardinals, and specifically Murray, relied a ton on Hopkins after acquiring him ahead of the 2020 season. Hopkins had a standout first campaign with 115 catches and 1,407 receiving yards on a 29.4% target share.

Brown is a solid player, but he just isn’t the same caliber of player as Hopkins. While he is used to dominating a lion’s share of the targets in Baltimore, he hasn’t managed the consistent production of a WR1. An aging A.J. Green, who Arizona re-signed this offseason, isn’t going to help much either.

While the Rams could suffer from a Super Bowl hangover and the 49ers will be adjusting to a new quarterback in Trey Lance, both Los Angeles and San Francisco are better bets to win the division right now.

Cardinals Make Playoffs Odds

Cardinals to Miss Playoffs (-125)

The Cardinals are now more likely to miss the playoffs than make them, according to sportsbooks, even despite how relatively weak the NFC is. Missing one of your best players for over a third of the season won’t help their chances.

Cardinals Win Total Bets 2022

Cardinals: UNDER 9 Wins (-140)

Arizona’s schedule is absolutely brutal. The Cardinals may have nine home games, but they will host the Chiefs, Chargers, Bucs, Saints, Eagles, and Patriots in addition to their divisional foes. Getting wins on trips to Atlanta, Carolina, Denver, and Las Vegas will be necessary to keep pace.

The loss of Hopkins will be a huge detriment to Murray, who has had his own injury issues to this point in his short NFL career. I don’t trust this team - or head coach Kliff Kingsbury - to get the job done.

Cardinals Prop Bets 2022

James Conner to Lead NFL in Rushing Touchdowns (+1500)

The former Steelers running back was a revelation in his first season in Arizona, rushing for 752 yards and 15 touchdowns in 2021. Touchdowns are a fickle beast, but it’s officially Conner’s backfield after Chase Edmonds moved on to Miami in the offseason.

Despite finishing second to Jonathan Taylor in rushing scores last season, Conner shares the sixth-best odds with Pittsburgh back Najee Harris. At that value, this bet is worth a look.

How to Bet Cardinals Moneylines

If you want to bet on the Cardinals to win a given game, you’re making an NFL moneyline wager. These NFL bets are very simple. You just have to pick a team to win a given game, and if they do, you win your bet.

Since all the team you pick has to do is win, the odds for NFL moneylines vary greatly based each team’s implied probability of winning (or losing) that contest. Favorites are identified by a minus symbol (-200), whereas underdogs are represented by a plus symbol (+200).

If the Cardinals are a (-200) favorite, you have to bet $20 to win $10. If they’re a (+200) underdog, you can win $20 off a $10 bet.

  • 2021 Cardinals Moneyline Record: 11-6

How to Bet Cardinals Spreads

Betting the spread is the most efficient way to wager on NFL games, as it presents two evenly priced options, regardless of the potential talent disparity between two teams. The spread, which is assigned a value by oddsmakers, is the number of points that the favorite is expected to win by against the underdog.

If the Cardinals are 3-point favorites over the Seahawks, the spread for that game will be set up like this: Cardinals -3 (-110) vs Seahawks +3 (-110).

In this scenario, the Cardinals would have to win by more than three points for you to win your bet. If they were to win by exactly three points, your bet would push and you would recoup your initial wager.

Arizona was one of the better teams in the league to bet on in 2021, covering the spread at a 58.8% clip.

  • 2021 Cardinals Against the Spread Record: 10-7

How to Bet Cardinals Over/Unders

Another way to bet on Cardinals games is by wagering on the total number of points scored in a particular contest.

Sportsbooks set the amount of combined points they expect both teams to score, and then you can bet on either the Over or the Under.

If you expect Murray and the Cardinals offense to play well in a given matchup, then you’ll probably want to take the Over. If you think it’ll be more of a defensive game, which could be the case early in the season without Hopkins, then you would bet the Under.

  • 2021 Cardinals Over/Under Record: 8-9


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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