49ers Odds 2024 | Best 49ers Spreads, Props, & More

Last Updated: Aug 11, 2023

The 49ers had an absolutely wild 2023 season. They started the year with Trey Lance at quarterback and ended with a barely-able-to-throw Brock Purdy (with some Jimmy Garoppolo and a dash of Josh Johnson mixed in along the way). Despite the rollercoaster ride, 2022 was a massive success as the 49ers still made the NFC Championship Game.

Fast-forwarding to 2023 (that’s why we’re here, right?!), the 49ers have a major question mark at quarterback but are largely untouched otherwise. With their conference relatively wide open, the 49ers’ Kyle Shanahan-driven system has them poised to make some noise in the NFC.

49ers Best Futures Odds

Click to find the top San Francisco 49ers betting lines with our NFL bets comparison tool:

NFL odds featured in this 49ers report were found at Caesars Sportsbook and are current as of May 31, at 3 P.M. ET.

49ers Win Total Odds

  • Over 11.5 Wins (+135)
  • Under 11.5 Wins (-155)

49ers Win Total Bet: Under (-155)

Caesars Sportsbook • WAGER: 0.75 units

While I think the 49ers will push 11 wins, I have a tough time seeing them eclipse that total—especially with their quarterback uncertainty. With games against the Bengals, Vikings, Eagles, Seahawks (twice), Ravens, and Cowboys on their schedule, that’s seven games that I’d consider a toss-up. And they can only lose five of those games (assuming they win all 10 of their other games – not exactly a guarantee) to hit 12-plus wins.

Can they accomplish that feat? Absolutely. Anything can happen. But I have a tough time putting any stock behind such an uncertain quarterback situation with this schedule.

49ers Make Playoffs Odds

  • Yes (-460)
  • No (+340)

49ers Make Playoffs Bet: Yes (-460)

Caesars Sportsbook • WAGER: 2.0 units

While I doubt 12-plus wins, I don’t doubt the 49ers are winning enough games to get into the NFC playoff picture. There is a good chance the NFC sees multiple (yes, multiple) sub-.500 playoff teams, and I think the 49ers have a good chance at winning their division, let alone gaining a wild card spot. Their system and supporting cast are just too good to let their quarterback situation derail them.

49ers Futures Prop Bets

Conference Winner (+320)

Caesars Sportsbook • WAGER: 0.50 unit(s)

This is a long shot (as the odds attest to), but the 49ers are fighting the Eagles and Cowboys for the NFC. Seattle and Minnesota might have something to say about that, but I don’t see any other teams fitting into that mix. If you agree with my thought process, you’re betting on the 49ers to finish above 3-5 of those teams. While their quarterback situation may hold them back here, it’s not a crazy thought.

Division Finishing Position: Second (+250)

DraftKings Sportsbook • WAGER: 0.50 unit(s)

It’s more likely that the 49ers will finish first, but I also think the quarterback uncertainty could easily hold them back and push the Seahawks into first place. If you’re out on my previous Conference Winner pick and worried about the 49ers at quarterback, this is the best for you!

Offensive Player of the Year: Christian McCaffrey (+1100)

Caesars Sportsbook • WAGER: 0.50 unit(s)

If you’re with me on that Conference Winner bet, you might be with me on Christian McCaffrey being the one who carries the 49ers there. Their uncertainty at quarterback will force San Francisco to rely upon CMC, and he very much has this award in him if he can stay healthy.

49ers Game Odds

Find NFL lines for every 49ers game this season and compare the best markets from our top sportsbooks:

49ers Best Player Prop Odds

Use our props tool to locate the top lines for your favorite 49ers players:

More NFC West odds: Arizona Cardinals | Los Angeles Rams | Seattle Seahawks

How to Bet on 49ers Games in 2023

How to Bet 49ers Moneylines

NFL moneyline wagers are the simplest forms of NFL bets. All you have to do is pick a team to win a given game, and if they do, you win your bet.

Since winning is the only requirement to cash your bet, the odds for NFL moneylines can vary greatly depending on each team’s implied probability of winning (or losing) that game. Favorites are designated by a minus symbol (-200), whereas underdogs are represented by a plus symbol (+200).

If the 49ers are a (-200) favorite against the rival Seahawks, you would have to bet $20 to turn a $10 profit. If San Francisco was a (+200) underdog, you would profit $20 off a $10 bet.

  • 2022 49ers Moneyline Record: 13-4

How to Bet 49ers Spreads

Betting the spread is the most efficient way to wager on NFL games, as it presents two evenly priced-options. The spread, which is assigned a value by the books, is the number of points that the favorite is expected to win by against the underdog.

If the 49ers are 6-point favorites over the Commanders, the spread for that game will be set up like this: 49ers -6 (-110) vs Commanders +6 (-110).

In this scenario, the 49ers would have to win by more than six points for you to win your bet. If they were to win by a pair of field goals, your bet would push, and you would recoup your initial wager.

San Francisco was 11-6 against the spread in 2022 and should be a decent bet moving forward as the roster is more or less the same from last season.

  • 2022 49ers Against the Spread Record: 11-6

How to Bet 49ers Over/Unders

If you don’t want to pick a side, you can still bet on 49ers games by wagering on the total number of points scored.

Sportsbooks set the number of combined points they expect both teams in the game to score, and then you can bet on either the Over or the Under.

If you expect Samuel, Kittle, and the 49ers to light up the scoreboard, then you’ll probably want to take the Over. If you think a specific game could be more defensive, then you would bet the Under. San Francisco’s games mostly exceeded scoring expectations last season, but they should be priced lower this year based on the uncertainty at quarterback.

  • 2022 49ers Over/Under Record: 9-8


Nick Roberts

Nick is an analyst at The Game Day who writes about the NFL and NBA from a betting perspective. He previously contributed to RotoWorld, Rotowire, and The New York Times. Nick resides in New Jersey.

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