49ers Odds 2023 | Best 49ers Spreads, Props, & More

Last Updated: Aug 31, 2022

Best 49ers Betting Lines 2023

The San Francisco 49ers snuck into the playoffs and then nearly ran to the Super Bowl, falling short in the NFC Championship Game against the eventual World Champion Los Angeles Rams.

2022 could be a lot different in the Bay Area. Trey Lance is officially taking over as the team’s starting quarterback, even though Jimmy Garoppolo is returning on a one-year deal. How far will Deebo Samuel and their 22-year-old signal caller take the 49ers?

Here’s a look at San Francisco’s betting odds for the 2022-23 NFL season.

49ers Futures Betting Odds

Note: These 49ers futures bet odds are current as of Wednesday, Aug. 31 at 3 p.m. ET and courtesy of FanDuel Sportsbook. You can find more odds at these US betting sites. But be careful, as many of these NFL futures odds might shift as we get closer to the 2022 NFL season.

  • Win Total: Over 9.5 (-160) / Under 9.5 (+135)
  • Make Playoffs: Yes (-198) / No (+160)
  • Win NFC West: (+170)
  • Win NFC Championship: (+750)
  • Win Super Bowl 57: (+1600)

🏈 to place any of these 49ers futures bets at FanDuel Sportsbook.

Check out more San Francisco 49ers promos.

49ers Super Bowl 57 Odds

49ers to Win Super Bowl (+1600)

The 49ers are among the favorites to win their first championship since the 1994 season.

Samuel led the NFL in yards per reception (18.2) last season, and he appears poised for another monster season. If San Francisco can turn Lance into even a passable quarterback, there’s enough talent on the roster to warrant a wager on the Niners as a title contender.

Still, nothing is a given in the NFL. The 49ers were only 13th in the NFL in points per game (25.1) in 2021, and that was with Samuel’s breakout, MVP-type campaign.

A hangover can’t be ruled out, especially given the expectations and a difficult schedule that includes seven games against 2021 playoff teams.

49ers NFC Championship Odds

49ers to Win NFC Championship (+750)

The 49ers should have the horses to contend for the NFC crown, which is why they have the fourth-shortest odds to represent the NFC in the Super Bowl.

The Niners have finished among the league’s final four in two of the past three seasons and came an eyelash short of winning the NFC again last season, blowing a 17-7 fourth-quarter advantage against the Rams in the NFC title game.

Plus, San Francisco should be dangerous with competent postseason quarterback play. Garoppolo is no slouch, but his play in the postseason was inconsistent as he was just 43-for-74 (58%) with two touchdowns and three picks.

Plus, he missed throws that could’ve extended drives in the Niners’ Wild-Card game against Dallas and the NFC Championship game against the Rams and failed to create a scoring drive in San Francisco’s divisional-round win against the Green Bay Packers.

Despite a 4-2 career postseason record, Garoppolo has a 4-6 touchdown-to-INT ratio in the playoffs in six career starts, including a killer, game-sealing pick-6 against Los Angeles last year. That’s a huge reason why the organization is prepared to move on to Lance, who it chose with the No. 3 pick in the 2021 draft, as its starting QB.

49ers NFC West Winner Odds

49ers to Win NFC West (+170)

The Niners currently have the second-shortest odds of any NFC West team, and this is a bet certainly worth taking a flier on.

Samuel’s return is massive, but this team still has enough skill-position talent aside from him. This includes George Kittle, who, when healthy, is among the best tight ends in the game.

In the backfield is 2021 leading rusher Elijah Mitchell, who had 1,100 scrimmage yards and 963 rushing yards despite playing just 11 games.

Plus, San Francisco has historically owned Los Angeles during the regular season — the Niners had won six straight regular-season meetings with the Rams dating back to 2018 — which could be the difference between who claims the division crown.

49ers Make Playoffs Odds

49ers to Miss Playoffs (+160)

Betting the ‘no’ on this is enticing since San Francisco is rolling out a new starting quarterback in Lance, who made just two starts in 2021.

Despite its loaded roster — especially on defense, where they surrendered the third-fewest scrimmage yards (310) and ninth-fewest points per game (21.5) and had the sixth-most sacks (48) — a hangover season isn’t out of the cards. The Niners went to the Super Bowl in 2019, falling to the Chiefs 31-20, then went 6-10 in 2020 with an equally loaded roster.

Plus, the current odds of the Niners missing the playoffs are almost too good to pass up.

49ers Win Total Bets 2023

49ers: UNDER 9.5 Wins (+135)

San Francisco had 10 wins last season and has averaged 9.67 wins per season over the past three seasons.

NBC Sports Washington reported the 49ers will have the fifth-toughest schedule by 2021 win percentage (.533, tied with the Kansas City Chiefs).

There can be drastic swings year-to-year in the NFL, but the Niners will have to face off against the defending world champs and 2021 playoff participant the Arizona Cardinals twice apiece, plus games against the Chiefs, much-improved Miami Dolphins, 2021 AFC wild card Las Vegas Raiders and nine-win Los Angeles Chargers.

A sub-10-win season is certainly within reason.

49ers Prop Bets 2023

Nick Bosa to Win Defensive Player of the Year (+1400)

Bosa is a bona fide game-wrecker, who had 15.5 sacks, the most by a 49ers player in 10 seasons, and four forced fumbles during the 2021 regular season.

The DPOY award can be team-result proof, unlike the MVP award which typically goes to the best player on the best team.

T.J. Watt was the runaway DPOY last season despite the fact the Pittsburgh Steelers narrowly squeaked into the playoffs, plus Bosa’s sack total jumped by six-and-a-half sacks from his rookie season, and if he can get into the 18-20 sack range in 2022, he’ll undoubtedly be a finalist.

How to Bet 49ers Moneylines

NFL moneyline betting is easy to get the hang of. All you have to do is pick the winner of the game, and you’ll win your bet.

For example, let’s say the 49ers are hosting the Seahawks. San Francisco would likely be a heavy favorite in this game, so they might have (-200) odds. This means you would need to bet $20 to win $10.

On the other hand, if the 49ers are playing on the road against the Rams, they might be a (+140) underdog. In this case, a $10 bet would win you $14 if the 49ers win the game.

  • 2021 49ers Moneyline Record: 10-7-0

How to Bet 49ers Spreads

Spread betting is extremely popular when it comes to betting on NFL games, and for good reason. You’re probably already familiar with it if you’ve heard of teams being “picked by" a certain number of points to win a game.

To bet spreads, you need to decide if a team will be able to win by the projected amount. For example, if the 49ers are playing the Seahawks, San Francisco might be a 7.5-point favorite. Therefore, if they win by eight points or more, they’ll cover the spread. But if they lose the game or win by seven points or less, Seattle will cover.

  • 2021 49ers Against the Spread Record: 9-8-0

How to Bet 49ers Over/Unders

Totals (or Over/Unders) are another easy way to bet on NFL games. Here, the winner doesn’t matter, nor does the margin of victory. Instead, we’re looking solely at the total number of points scored in a game.

Before a matchup begins, oddsmakers will set a total that they believe will be how many points are scored in the game. From there, it’s up to you to determine whether the total will come in Over or Under that number.

Make sure you’re up-t0-date on key storylines and injuries before placing these types of bets, as these are the types of things that can swing a total much higher or lower than the projected number.

  • 2021 49ers Over/Under Record: 8-9-0


Pat Pickens

Pat Pickens is a seasoned sportswriter who has covered pro sports since 2013 for various websites, including The New York Times,, Bleacher Report,, USA Today, the Associated Press and many others. His debut book, titled "The Whalers" about the history of the NHL's Hartford Whalers, was released in October 2021.

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