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49ers Betting Odds 2022 | 49ers Best Prop Bets

The San Francisco 49ers snuck into the playoffs and then nearly ran to the Super Bowl, falling short in the NFC Championship Game against the eventual World Champion Los Angeles Rams.

Still, 2022 could be a lot different in the Bay Area. Wide receiver/all-everything offensive weapon Deebo Samuel, who led San Francisco with 1,770 all-purpose yards and 14 touchdowns, reportedly has asked to be traded, and San Francisco is expected to give second-year quarterback Trey Lance the reins after a subpar postseason from 2021 starter Jimmy Garoppolo. 

The 49ers still probably will trade Garoppolo before their Week 1 game against the Chicago Bears, though offseason shoulder surgery has thrown a wrinkle into those plans. There’s still a lot of uncertainty surrounding the 49ers, but here’s a look at how things stand at the moment.

Note: These 49ers’ futures bet odds are current as of 1 p.m. on May 13, 2022, and courtesy of Caesars Sportsbook. Be careful, as many of these NFL odds might shift as we get closer to the 2022 NFL season.

49ers Betting Odds

  • Win Total: Over 10 (-115) / Under 10 (-105)
  • Make Playoffs: Yes (-220) / No (+180)
  • Win NFC West (+190)
  • Win NFC Championship (+700)
  • Win Super Bowl 57 (+1500)

49ers Super Bowl 57 Odds

49ers to Win Super Bowl (+1500)

The 49ers are among the favorites to win their first championship since the 1994 season despite the uncertainty swirling around their roster.

If the organization can patch things up with Samuel, who led the NFL in yards per reception (18.2), and can turn Lance into even a passable quarterback, there’s enough talent on the roster to warrant a wager on the Niners as a title contender.

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Still, nothing is a given in the NFL, and if Samuel is traded then these odds should lengthen drastically. The 49ers were only 13th in the NFL in points per game (25.1) in 2021, and that was with Samuel’s breakout, MVP-type campaign.

A hangover can’t be ruled out, especially given the roster drama, expectations, and a difficult schedule that includes seven games against 2021 playoff teams.

49ers NFC Championship Odds

49ers to Win NFC Championship (+700) 

The 49ers should have the horses to contend for the NFC crown, especially if Samuel stays, which is why they have the fourth-shortest odds to represent the NFC in the Super Bowl.

The Niners have finished among the league’s final four in two of the past three seasons and came an eyelash short of winning the NFC again last season, blowing a 17-7 fourth-quarter advantage against the Rams in the NFC title game.

Plus, San Francisco should be dangerous with competent postseason quarterback play. Garoppolo is no slouch, but his play in the postseason was inconsistent as he was just 43 for 74 (58 percent) with two touchdowns and three picks.

Plus, he missed throws that could’ve extended drives in the Niners’ wild-card game against Dallas and the NFC championship game against the Rams and failed to create a scoring drive in San Francisco’s divisional-round win against the Green Bay Packers.

Despite a 4-2 career postseason record, Garoppolo has a 4-6 touchdown-to-INT ratio in the playoffs in six career starts, including a killer, game-sealing pick-6 against Los Angeles last year. That’s a huge reason why the organization is prepared to move on to Lance, who it chose with the No. 3 pick in the 2021 draft, as its starting QB.

49ers NFC West Winner Odds

49ers to Win NFC West Championship (+190)

The Niners currently have the second-shortest odds of any NFC West team, and this is a bet certainly worth taking a flier on, again if Samuel is on the roster.

Plus, San Francisco has enough skill-position talent aside from Samuel on its roster, including George Kittle who, when healthy, is among the best tight ends in the game.

Trey Sermon should be healthy enough to contribute to a backfield that also includes 2021 leading rusher Elijah Mitchell, who had 1,100 scrimmage yards and 963 rushing yards despite playing just 11 games.

Plus, San Francisco has historically owned Los Angeles during the regular season — the Niners had won six straight regular-season meetings with the Rams dating back to 2018 — which could be the difference between who claims the division crown.

49ers Make Playoffs Odds

49ers to Miss Playoffs (+180)

The 49ers should be considered a playoff lock if Samuel is not traded. Still, betting the ‘no’ on this is enticing since San Francisco is likely to roll out a new starting quarterback in Lance, who made just two starts in 2021, and given the drama involving Samuel.

Despite its loaded roster, especially on defense, where they surrendered the third-fewest scrimmage yards (310) and ninth-fewest points per game (21.5) and had the sixth-most sacks (48), a hangover season isn’t out of the cards. The Niners went to the Super Bowl in 2019, falling to the Chiefs 31-20, then went 6-10 in 2020 with an equally loaded roster.

Plus, the current odds of the Niners missing the playoffs are almost too good to pass up.

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49ers: Miss the Playoffs

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49ers Win Total Bets 2022

49ers: UNDER 10 Wins (-105)

San Francisco had 10 wins last season and has averaged 9.67 wins per season over the past three seasons.

NBC Sports Washington reported the 49ers will have the T5th toughest schedule by 2021 win percentage (.533, tied with the Kansas City Chiefs).

There can be drastic swings year-to-year in the NFL, but the Niners will have to face off against the defending world champs and 2021 playoff participant the Arizona Cardinals twice apiece, plus games against the Chiefs, much-improved Miami Dolphins, 2021 AFC wild card Las Vegas Raiders and nine-win Los Angeles Chargers, a sub-10-win season isn’t out of the cards for the 49ers.

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49ers: UNDER 10 Wins

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49ers Prop Bets 2022

Nick Bosa to Win Defensive Player of the Year (+1400)

Bosa is a bona fide game-wrecker, who had 15.5 sacks, the most by a 49ers player in 10 seasons, and four forced fumbles during the regular season last year.

The DPOY award can be team-result proof, unlike the MVP award which typically goes to the best player on the best team.

T.J. Watt was the runaway DPOY last season despite the fact the Pittsburgh Steelers narrowly squeaked into the playoffs, plus Bosa’s sack total jumped by six-and-a-half sacks from his rookie season, and if he can get into the 18-20 sack range in 2022, he’ll undoubtedly be a finalist.

Player Prop


Nick Bosa: Defensive Player of the Year

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Schedule & Odds

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NBA Betting News

  • Celtics +300 to win NBA Title

    The Boston Celtics are +300 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics are +300 ahead of their home date with the Warriors for Game 6. We will see a considerable odds shift if the Celtics can win Game 6 on their homecourt. Boston was +310 after Game 5.

  • Celtics vs. Warriors over/under listed at 210

    The over/under for Game 6 of the NBA Finals between the Boston Celtics and the Golden State Warriors is listed at 210, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210, down from the 210.5 it opened at. 60 percent of the public action has come on the over.

  • Warriors -400 to win NBA Championship

    The Golden State Warriors are -400 to win the NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    Golden State now sits at a prohibitive -400 to win the NBA Championship. For comparison, Stephen Curry MVP is -360. Andrew Wiggins, the dark horse to steal the award with a big close-out game, sits at +2000.

  • Celtics +310 to win NBA Championship

    The Boston Celtics are +310 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics peaked as high as high as -230 prior to Game 3 and now sit at an attractive +310. Boston entered the season at +4000. The odds could swing wildly again if Boston wins Game 6.

  • Warriors vs. Celtics over/under listed at 210.5

    The over/under for Game 5 of the NBA Finals between the Golden State Warriors and the Boston Celtics is listed at 210.5, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210.5, down from the 212.5 it opened at. 72 percent of the public action has come on the over.