NFL Season Predictions 2025

The 2025 NFL season is always full of surprises, so it shouldn’t be too shocking to see things like the Colts off to an undefeated start and the Ravens or Chiefs staring at 1-3 after Week 4.

That’s what makes NFL predictions so fun because you can always expect the unexpected.

On this page, you’ll find weekly NFL predictions, which can be used to inform your best football bets.

NFL Predictions: Week 4

Read more about our NFL Week 4 predictions for best bets this week.

Thursday Night Football: Seahawks vs Cardinals

We’ve got an NFC West divisional tilt between a pair of 2-1 teams in what should be a close game. Read our Thursday Night Football best bets for more about this matchup.

NFL International Series - Dublin: Vikings vs Steelers

Can Carson Wentz make it two wins in a row for the Vikings as he takes over for the injured J.J. McCarthy? Or will Aaron Rodgers get a much-needed win for the Steelers in this Dublin matchup?

Saints vs Bills

The Bills look like one of the best teams in the NFL, set for another blowout win against the Saints, who are quite easily the worst team in football right now. Don’t expect this one to be close at all.

Titans vs Texans

Two winless teams go at it in this AFC South matchup. It’s a must-win game for the Texans, who came into the season with playoff aspirations. You have to think that their defense will be too much for rookie quarterback Cam Ward.

Browns vs Lions

The Lions are coming off a statement win on Monday Night Football against the Ravens, so knocking off the Browns at home should be a much easier feat. However, the Browns defense is legit, so keep that in mind.

Commanders vs Falcons

The Commanders are likely to play another game without Jayden Daniels here. Look for the Falcons to get back on track following an abysmal performance vs the Panthers.

Eagles vs Buccaneers

The Eagles front-seven is likely to cause major issues for Baker Mayfield and the Bucs, especially since they have such an injury-plagued offensive line.

Panthers vs Patriots

It’s a battle of two young quarterbacks in Bryce Young vs Drake Maye. Give the edge to the Patriots since they’re at home and their defense is getting healthier with top corner Christian Gonzalez.

Chargers vs Giants

Jaxson Dart takes over as Giants starter. With dual-threat ability and a gunslinging mindset, Dart is going to surprise people. I like the G-Men to pull off the upset here.

Jaguars vs 49ers

The 49ers defense has been a major problem this year, while the Jaguars offense is still a work in progress. With Brock Purdy likely to return, San Fran should get it done at home here.

Colts vs Rams

The Colts have shocked observers with their 3-0 start, but they have a true test on the road against the Rams. Look for Matthew Stafford and company to win in a likely shootout.

Bears vs Raiders

The Bears offense was firing on all cylinders in a win over the Cowboys last week. It appears that Ben Johnson is starting to get this group to buy into his scheme. Look for another Chicago win here.

Ravens vs Chiefs

Two Super Bowl contenders that are staring at a 1-3 start go at it here. I give the edge to the Ravens because the Chiefs are still banged up on offense.

Sunday Night Football: Packers vs Cowboys

Micah Parsons makes his return to Dallas in this Sunday nighter. The Cowboys have an injury-plagued offensive line and are playing without top wideout CeeDee Lamb. Bad news against this elite defense.

Monday Night Football: Jets vs Dolphins

Two winless teams go at it in this AFC East showdown. Justin Fields is expected to return from a concussion. This game can go either way, but I lean with the Jets because Miami looks like a sinking ship right now.

Monday Night Football: Bengals vs Browns

The Bengals are likely to bounce back after getting blown out by the Vikings. Jake Browning isn’t as bad as he looked last week. While Denver should win, it’s going to be much closer than the spread suggests.

NFL Season Predictions 2025

Check out our NFL Season Predictions below. These were our picks coming into the 2025 NFL season:

Above all else, parity makes the NFL one of the best sports leagues in the world. Every year, at least one team goes from worst to first in its division, exceeding expectations and pushing its way into the postseason.

With that parity comes surprising twists and turns throughout the campaign, making the art of predicting which teams and players will succeed on any given Sunday, let alone in a given season, all the more difficult.

Below, our experts provide their predictions for the upcoming 2024 NFL season.

There is no shortage of intrigue for the 2025 NFL season. Our predictions have only two new division winners, with the San Francisco 49ers bouncing back to retake the NFC West and the Atlanta Falcons emerging to supplant the Tampa Bay Buccaneers in the NFC South.

We’ve got Mike Vrabel winning Coach of the Year in his return to the NFL scene with the New England Patriots, who look poised to surprise the league with a postseason berth this year. On the player side of awards, Ashton Jeanty is set up nicely to put up tremendous numbers as the Las Vegas Raiders’ bellcow.

But what about Super Bowl, NFL MVP, and other prominent awards? Read below for our NFL best bets on those markets.

Super Bowl 60 Winner Best Bet

Super Bowl 60 Winner: Baltimore Ravens (+600)

DraftKings Sportsbook • WAGER: 1 unit

It’s the Ravens’ year, folks. This is the perfect setup for a Super Bowl title.

You have continuity at coaching, with John Harbaugh leading the way. Todd Monken has put together a terrific offensive scheme that is getting the most out of Lamar Jackson.

The defense came on strong in the second half, and is now bolstered by Jaire Alexander along with rookies Malaki Starks and Mike Green.

Simply put, there are no holes on this roster. Look for the Ravens to finally get it done for Lamar’s first ring.

Currently near the top in Super Bowl odds, the Ravens are still at a reasonable price to take home the hardware.

NFL Conference Winner Best Bet 2025

NFC Winner: Detroit Lions (+650)

DraftKings Sportsbook • WAGER: 1 unit

While some are concerned that the Lions will fall off now that they lost their two stud coordinators Ben Johnson and Aaron Glenn, I’m not buying it.

This roster is too stacked to fall off this year. Plus, Dan Campbell remains one of the best head coaches in the NFL.

The Lions are out for blood this season.

This is a team that was robbed of a Super Bowl run due to injuries. Their defense was absolutely dismantled, highlighted by the loss of stud edge rusher Aidan Hutchinson.

Now healthy, expect this group to perform at a much higher level this time around, resulting in a Super Bowl berth.

NFL Division Winner Best Bet 2025

NFC South Winner: Atlanta Falcons (+220)

DraftKings Sportsbook • WAGER: 1 unit

The NFC South is ripe for the taking because the Tampa Bay Buccaneers are dealing with a key injury to All-Pro offensive tackle Tristan Wirfs.

The Atlanta Falcons did a great job addressing their pass-rushing needs in the draft, spending premium capital on Jalon Walker and James Pearce Jr.

Michael Penix Jr. is a huge upgrade at quarterback over Kirk Cousins, who played injured last season.

Expect Drake London to take a big leap at receiver, with the Falcons taking over this division in the process.

NFL Award Best Bet 2025

NFL MVP Winner: Patrick Mahomes, QB, Kansas City Chiefs (+700)

DraftKings Sportsbook • WAGER: 1 unit

All offseason, the Chiefs have prioritized how they’re going to get back to generating explosive passing plays.

I’m betting that this will happen, resulting in a return to a highly productive season for Patrick Mahomes.

With NFL MVP odds at a reasonable price of +700, Mahomes looks like a solid wager.

Bet on the best quarterback in the NFL to carry the Chiefs to yet another AFC West division title.

Stay on top of all the action this season with our NFL betting tips.