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49ers NFL Draft Pick Predictions & Odds | 2022 Draft Team Needs & Futures Bets

There were two distinct halves to the 49ers’ 2021 season. By Week 9, San Francisco had lost five of its first eight games and was on a similar pace to the 6-10 49ers team of the previous season.

Then the Niners hit their stride, winning seven of their next nine games and finishing the regular season with a thrilling overtime win against the Rams. They stayed hot in the postseason, beating Dallas in the NFC Wild Card Game and upending the Packers in the Divisional Round.

All three of their final and impressive victories came on the road.

A campaign that was thrilling in its final weeks ended with a disappointing loss to the Rams in the NFC Championship Game, but the 49ers ultimately exceeded expectations.

Now, the big question is when the Trey Lance era begins. San Francisco is currently without a first-round pick in 2022 after trading up for him in last year’s NFL Draft.

49ers NFL Draft Picks 2022

  • Round 2, Pick 29 (61st Overall)
  • Round 3, Pick 29 (93rd Overall)
  • Round 3, Pick 41 (105th Overall) — Compensatory
  • Round 4, Pick 29 (134th Overall)
  • Round 5, Pick 29 (172nd Overall)
  • Round 6, Pick 8 (187th Overall, via DEN)
  • Round 6, Pick 42 (220th Overall) — Compensatory
  • Round 6, Pick 43 (221st Overall) — Compensatory
  • Round 7, Pick 41 (262nd Overall) — Compensatory

Unless they pull off a trade for Jimmy Garoppolo soon, or actually move Deebo Samuel, the 49ers draft late in nearly every round, and this is the first time since 1996 that the team does not have a first-rounder. San Francisco does have nine overall picks, with four being compensatory selections, including the final overall selection.

John Lynch and Kyle Shanahan have shown they can nail some later picks well, as George Kittle was a fifth-rounder, Fred Warner was taken in the third, and Elijah Mitchell was a pleasant surprise as sixth-rounder in 2021.

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49ers Team Needs 2022

1. Offensive Line

Losing Laken Tomlinson in free agency makes this the most pressing need heading into the 2022 NFL Draft. There are also concerns at right tackle, but both guard spots now look shaky. It remains to be seen how comfortable San Francisco is with its internal options.

Daniel Brunskill has been signed to return, and can be an option at right guard, but an upgrade would be ideal if possible. The 49ers may also feel that Aaron Banks, who they drafted in the second round last year, could be ready to take over a starting spot.

The Niners don’t have much cap space available to bring in a desired veteran, but a trade could free up some room to bring in a veteran or they can maneuver into a better position to draft an impact lineman with a Garoppolo or Samuel deal.

San Francisco lost Tom Compton at tackle, but the franchise is hopeful Mike McGlinchey will be healthy for the 2022 campaign.


If the 49ers utilize one of their first available selections on a possible offensive line starter, they will then have to address the defense quickly thereafter. Of course, Nick Bosa anchors the pass rush, but he needs some more reliable help.

San Francisco may be regretting its trade for Dee Ford in 2019, as he, unfortunately, landed on injured reserve in each of the last two seasons and is not expected to be back. The 49ers did finish sixth in the NFL in sacks last season with 48, but they will also have to replace Arden Key, who was second on the team with 6.5 sacks.

The Niners must account for the losses of Ford and Key, and while Arik Armstead is certainly a factor in the middle, the team has to land another pass rusher to possibly pair with Bosa. San Francisco should make a potential impact addition in this area to maintain the level of pass pressure.

3. Cornerback

As the 49ers get deeper into the draft, expect them to add some depth at cornerback. Losing K’waun Williams will likely prompt the team to make a move at the position among their first few selections, even if not with one of the first two available picks.

Signing Charvarius Ward was a significant priority move in free agency. Emmanuel Moseley and Ambry Thomas give the 49ers a good grouping to anchor the position.

Having the Rams and Cooper Kupp as the main rivals in the NFC West should be a strong reason why San Francisco will make sure to further bolster this unit. They also have Kyler Murray, DK Metcalf and Tyler Lockett to contend with twice a year.

49ers May Also Consider Drafting: Safety, Wide Receiver, Defensive Tackle, Tight End

49ers NFL Mock Draft Predictions 2022

  • Round 2, Pick 29 (61st Overall): Jamaree Salyer, Guard, Georgia
  • Round 3, Pick 29 (93rd Overall): Sam Williams, EDGE, Ole Miss
  • Round 3, Pick 41 (105th Overall): Marcus Jones, CB, Houston
  • Round 4, Pick 29 (134th Overall): Markquese Bell, S, Florida A&M

More Possible 49ers Draft Targets: Cameron Thomas, EDGE, San Diego State; Coby Bryant, CB, Cincinnati

49ers NFL Draft Bets 2022

Mr Irrelevant: Offensive Player Picked (-115) at Betway

As it stands, the 49ers have the final pick in the 2022 NFL Draft, which means they’ll have the honor of selecting this year’s Mr. Irrelevant. Who they’ll select with that pick remains to be seen, but if we had to guess, it would make sense for San Francisco to draft a player who can help on the offensive side of the ball.

In our mock draft, we have three of the Niners’ first four picks being used to select defensive players. Since that’s the more pressing need for this ball club, it makes sense that they would use their more valuable picks to bolster that group and save their late-round picks for potential offensive gems.

As mentioned previously, the 49ers struck gold in the fifth round with Kittle and in the sixth round with Mitchell. Perhaps they can find another offensive playmaker with the final pick in this year’s draft?

Player Prop


Mr. Irrelevant: Offensive Player

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