Dolphins vs 49ers Predictions & Odds

Last Updated: Nov 30, 2022

Coming off an absolute beatdown over the Texans, Tua Tagovailoa and the Miami Dolphins head to San Francisco to face Jimmy Garoppolo and the 49ers in Week 13

The Dolphins are 8-3 and sit atop the AFC East, just edging out the Buffalo Bills for first place. Miami has now won five-straight, including a dominant Week 12 victory where they embarrassed the Texans and didn’t even use their starters for the majority of the second half.

As for San Francisco, they’re fresh off a shutout against the New Orleans Saints and sit in first place in the NFC West. Their defense has been playing great and they’ve won four games in a row after a two-game losing streak.

Continue reading for my predictions and best bets to target in this matchup as the Miami Dolphins hit the road to take on the San Francisco 49ers.

Dolphins vs 49ers Odds

Garoppolo and the 49ers opening up as the early home favorites makes sense. The 49ers are in first place, their defense has been fantastic, and their offense is loaded with weapons.

The 49ers’ stout defense taking on the electric offense of Miami will be an exciting matchup to watch.

Take a look at the best Dolphins odds and 49ers odds for the 2022 NFL season.

Dolphins vs 49ers Implied Totals

49ers 25, Dolphins 21.5

As of Monday evening, at FanDuel Sportsbook, the bookmakers are giving the home team the edge. The 49ers are favorites to win this one over the Dolphins by 3.5 points.

Dolphins vs 49ers Pick of the Day

Read more on this Dolphins vs 49ers bet below.

Dolphins vs 49ers Prediction

49ers 30, Dolphins 27

As the former offensive coordinator for the 49ers, Miami head coach Mike McDaniel returns to San Francisco with his new team. The Dolphins acquired Tyreek Hill his offseason, and between Hill and second-year wide receiver Jaylen Waddle, they’ve been extremely fun to watch.

Speaking of fun to watch, this 49ers offense fits that description as well. Since acquiring star running back Christian McCaffrey from the Panthers, Garoppolo has had plenty of weapons to choose from. Deebo Samuel might run for a touchdown, and on the next possession, McCaffrey might catch one. Needless to say, they can attack you from all over the field.

Still, while the Dolphins’ offense has been one of the best in the NFL (25.6 points per game, sixth-best in the NFL), their defense has been underwhelming (19th in the NFL at 23.3 points per game allowed).

The San Francisco offense is middle of the pack at 22.6 points per game, but since acquiring McCaffrey, they’re at 25.4 points per game. That, coupled with their NFL-leading defense (15.7 points per game allowed), has me taking the 49ers to win this one outright.

This could be one of the most exciting matchups of the week and a high-scoring one at that.

Dolphins vs 49ers Bet Tips

Here are a few Dolphins vs 49ers betting trends to consider before making your bets:

  • The total has gone Over in four of the last five matchups between these two teams.
  • The total has gone Over in four of Miami’s last five road games.
  • Both teams are 6-5 against the spread this season.

Dolphins vs 49ers Best Bets

Over 46.5 Points (-110) at FanDuel Sportsbook

WAGER: 1 Unit

While this 49ers defense has been tough and offenses tend to struggle against them, Hill and Waddle are the best wide receiver duo in the NFL. Tagovailoa has made strides this year with his passing, and I’m betting they’ll produce despite the tough matchup.

The Dolphins are averaging 291.5 passing yards per game — second in the NFL behind the Chiefs — and Tagovailoa has 19 passing touchdowns, tied for fifth in the league. They’ll put up a fight against one of the toughest defenses in the NFL, and with their weak defense, could be forced to air it out if they fall behind.

Miami’s running game has also stepped up as of late, and former 49ers running back Jeff Wilson has scored in three-straight games. Raheem Mostert is also now with the Dolphins, and he might play against his former team after missing last week with a knee injury.

Before placing this bet, get the best 49ers promo codes.

Dolphins +3.5 (-110) at FanDuel Sportsbook

WAGER: 0.5 Units

While the 49ers are the favorite in this one and the team I’m predicting to win, it’s worth considering betting on the Dolphins to cover. I think as the game gets closer, we might see this line tighten up a bit as well.

As of Monday night, you can get the Dolphins at +3.5 points at decent odds. Don’t be surprised if you see this line move closer to 1 or 1.5 points before game time. Miami will put up a fight and could very well win this one, so taking the points on them to cover makes sense.

Before placing this bet, get the best Dolphins promo codes.

Dolphins vs 49ers Props

Check out the best Dolphins vs 49ers player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Miami vs San Francisco game and see all of its prop bets.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $5, Get $150 in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get A Bonus Bet Up To $250

5 stars

Bet $5, Get $200 in Bonus Bets Every Day for 5 days!

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.