Monday Night Football Predictions Week 14 | MNF Picks & Rams vs Cardinals Best Bets

Last Updated: Dec 13, 2021

We’ve reached Week 14 of the NFL season, and the Arizona Cardinals still have the NFL’s top record (10-2) despite losing Kyler Murray and DeAndre Hopkins for multiple games. They’ve also opened up a two-game lead over the Los Angeles Rams in the NFC West and could essentially clinch the division with a win on Monday Night Football.

The Rams are still in the hunt, however, and could cut Arizona’s lead in half with a victory. Needless to say, this is a huge game for both sides.

So who should you bet on in this NFC West battle? Let’s dive in with our best MNF bets and Rams vs Cardinals predictions.

Please note that all NFL Week 14 MNF odds and lines are current as of 2 PM EST on Friday, December 10.

Monday Night Football Prediction Week 14

Both teams are coming off easy wins against losing teams in Week 13. The Cardinals won their second straight game with a 33-22 victory over the Chicago Bears, while the Rams snapped their three-game losing streak with a 37-7 rout of the Jacksonville Jaguars.

In the previous meeting between these two teams during Week 4, Los Angeles suffered its first defeat of the season with a 37-20 home loss to Arizona. LA’s defense will need to step up this time around against a Cardinals offense that’s averaging 28.6 points per game — fourth-most in the NFL.

Sportsbook Play of the Day

Before making your best MNF betting picks, you should know that TwinSpires Sportsbook is one of the best around. Take advantage of TwinSpires’ outstanding welcome bonus which gives you a with no promo code required.

Read Anthony Cervino’s TwinSpires Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our best MNF tipster picks.

As for Arizona, they appeared rejuvenated last week following their bye and are finally healthy again with both Murray and Hopkins back on the field. While the Rams’ defense has been up and down this year, the Cardinals’ unit has been one of the stingiest in the NFL with 18.7 points allowed per game — fourth-fewest in the NFL.

With how well the Cardinals have been clicking on both sides of the ball, don’t expect them to slip up at home against a Rams team that hasn’t won on the road since Week 8. Arizona is the better team and should prove it again here in primetime.

NFL Week 14 MNF Prediction: Cardinals 30, Rams 23

Odell Beckham Jr Matthew Stafford Los Angeles Rams

Can the Los Angeles Rams win their rematch with the Arizona Cardinals on Monday Night Football during NFL Week 14? (Image: USA TODAY Sports)

Monday Night Football Best Bets Week 14

MNF Best Bet: Cardinals -2.5 (-109) on TwinSpires

Wager: 1 Unit

It’s somewhat surprising that the Cardinals are less than a field goal favorite at home against the Rams on our NFL gameday odds. Arizona has been the superior team this season, featuring a rushing attack and defense that make them difficult to beat.

While the last meeting between these two clubs was a 17-point win for the Cardinals, it’s fair to expect a closer game this time. But will Arizona win by at least a field goal? That does seem likely.

Take the Cardinals to cover here and expect them to get their 11th win of the season against the Rams on Monday Night Football.

Check out more of our NFL Week 14 betting tips:

MNF Best Bet: Over 51.5 Total Points (-110) at TwinSpires

Wager: 1 Unit

Both of these offenses rank in the top six in scoring this year and are averaging at least 28 points per game. Murray and Matthew Stafford are two of the best quarterbacks in the NFL and can put points on the board in a hurry.

These are two explosive offenses with tons of playmakers on both sides. Take the Over for our NFL bet of the day and expect a shootout in the desert.

Thanks for reading our NFL Week 14 MNF Predictions! For more NFL betting tips, check out our NFL Week 14 Parlays Picks.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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