NFL Week 18 Best Bets | Predictions & Picks for NFL Week 18

We have made it. The final week of the 2021-2022 season is upon us, and there are several games with huge playoff implications in Week 18. However, there are a number of games this week that could be difficult to bet on considering we aren’t quite sure who will be in or out of the lineup.

To get you prepared for the week ahead, here are our best bets and picks for Week 18 of the NFL season.

Please note that all NFL gameday odds and lines are current as of 5 p.m. ET on Wednesday, January 5.

Marcus Mosher’s Best Bets NFL Betting Record: 58-42

Pittsburgh Steelers vs Baltimore Ravens Prediction

Both the Steelers and the Ravens need help in order to make the playoffs this season. Both teams need the Colts to lose to the Jaguars in order to have any chance of making the postseason. However, with that game happening at the same time as this contest, we can expect a playoff-like atmosphere between the Ravens and the Steelers.

But the bigger issue here is that neither of these teams are all that good. The Ravens have been crushed with injuries this season, and it’s not clear if Lamar Jackson will be able to return for the team’s final regular-season game.

Pittsburgh is a much healthier team, but they aren’t really any better. But expect a typical hard-fought game that likely comes down to the final possession, just like every other Ravens-Steelers game.

Steelers vs Ravens Prediction: Steelers 20, Ravens 17


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Steelers vs Ravens Best Bet: Steelers +5.5 (-108) on TwinSpires

Wager: 1 Unit

Pittsburgh is coming off an emotional win in Week 17 in what was Ben Roethlisberger’s final game at Heinz Field. He did not play well, but the defense stepped up and bailed him out. They sacked Baker Mayfield nine times and shut down their passing attack.

Mike Tomlin‘s defense should be able to do something similar in this game, even if Jackson is under center. We like the Steelers to win outright, so getting them +5.5 points is just too good of a value – even in Baltimore.

spread

-108

Steelers Cover +5.5 Spread @ Ravens

PIT @ BAL | 01/09, 1:00 PM ET

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Steelers vs Ravens Best Bet: Under 41.5 (-110) on TwinSpires

Wager: 1 Unit

Points are going to come at a premium in this game. While neither defense has been elite all season long, they do have the pass rushers to make life difficult on the opposing quarterback.

Look for each team to lean on their rushing attack to shorten the game. For that reason, take the Under for our NFL bet of the day and expect the winner to score only in the low-20s on Sunday.

over-under

-110

Steelers @ Ravens: UNDER 41.5 Points

PIT @ BAL | 01/09, 1:00 PM ET

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Lamar Jackson Baltimore Ravens QB

Can Lamar Jackson return from injury to lead the Baltimore Ravens past the Pittsburgh Steelers in Week 18? (Image: USA TODAY Sports)


Seattle Seahawks vs Arizona Cardinals Prediction

After a big win in Dallas, the Arizona Cardinals still have a chance to win the NFC West. They need a win on Sunday plus a loss by the Rams in Week 18. But the Rams will face the 49ers, who have beaten them in five-straight games.

With the Seahawks having nothing to play for in this game, look for the Cardinals to win outright and clinch their 12th win of the season. They are just the far better team and are looking to continue to add some positive momentum entering the playoffs.

Seahawks vs Cardinals Prediction: Cardinals 27, Seahawks 20 

Seahawks vs Cardinals Best Bet: Cardinals -6.5 (-110) on TwinSpires

Wager: 1 Unit

Yes, the Seahawks blew out the Lions in Week 17, but this is still a bad football team. The Cardinals are simply better and proved that earlier in the season when they beat them in Seattle with Colt McCoy under center. But Kyler Murray is back in the lineup, and he finally looks healthy, which should be a terrifying thought for the rest of the NFC.

The Cardinals have too much to gain to lay an egg in Week 18 and you can expect that they are going to want to put some pressure on the Rams on Sunday. Take the Cardinals to win by at least a touchdown in the NFC West matchup.

spread

-110

Cardinals Cover -6.5 Spread vs Seahawks

SEA @ ARI | 01/09, 4:25 PM ET

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Seahawks vs Cardinals Best Bet: Under 48 (-110) on TwinSpires

Wager: 1 Unit

Unless the Seahawks are playing a team with fewer than five wins like the Lions, Texans, or Jaguars, this is an offense that has really struggled to score points. They are averaging only 22.3 points per game, and that number is far fewer when they are playing a good team.

Arizona’s defense should be able to create a ton of pressure in this game, helping keep the point total down. For that reason, take the under 48 here and expect Seattle to struggle to score more than 20 points in Week 18.

over-under

-110

Seahawks @ Cardinals: UNDER 48 Points

SEA @ ARI | 01/09, 4:25 PM ET

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Los Angeles Chargers vs Las Vegas Raiders Prediction

The final game of the 2021-2022 season will essentially be a playoff game in Las Vegas. The Chargers and Raiders will play in an AFC West matchup where the winner will be in the playoffs.

The Raiders have won their last three games, which has put them in a win-and-in position going into Week 18. However, they just don’t match up well against the Chargers.

In the previous meeting, the Chargers won by two touchdowns and Justin Herbert had a monster day. Expect more of the same in this game as the second-year quarterback should be able to lead his team to the playoffs.

Chargers vs Raiders Prediction: Chargers 31, Raiders 20

Chargers vs Raiders Best Bet: Chargers -3 (-112) on TwinSpires

Wager: 1 Unit

The Chargers are one of the more frustrating teams in the NFL, but they are finally starting to get healthy. They just scored 34 points against the No. 1 ranked scoring defense in the NFL in Week 17 (Broncos) and the defense looked fairly competent.

With Derek Carr still struggling to find any rhythm without Henry Ruggs, the offense for the Raiders probably won’t be able to keep up. They have just two games since Week 7 where they have scored more than 17 points.

For that reason, the Chargers -3 is a great bet in the final game of the season.

spread

-112

Chargers Cover -3 Spread @ Raiders

LAC @ LV | 01/09, 4:25 PM ET

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Chargers vs Raiders Best Bet: Over 49.5 (-110) on TwinSpires

Wager: 1 Unit

The Chargers are one of the most explosive offenses in the NFL, and from everything we’ve seen, Herbert dices up divisional opponents. It seems very likely that the Chargers will score at least 30 points in this game, which makes the over an easy bet.

As long as Carr and the Raiders can score close to 20 points, the over should hit here in Las Vegas.

over-under

-110

Chargers @ Raiders: OVER 49.5 Points

LAC @ LV | 01/09, 4:25 PM ET

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Thanks for reading our NFL Week 18 Best Bets! For more NFL betting tips, check out our NFL Week 18 Prop Bets and NFL Week 18 Parlays.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page