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TGD Staff NFL Picks ATS | Week 1

Last Updated: Sep 4, 2025

Think you’ve got what it takes to outsmart your co-workers with your NFL ATS picks this season? Us too.

This season, the TGD staff will be picking every NFL game against the spread in a season-long competition that will run through Super Bowl 60 in Santa Clara, California. We’ll also break down our best ATS bet for each week, and see who can compile the best record over the course of the year.

Whether you’re playing in your office pick’em pool or a high-profile ATS picks contest, we’ll give you all the insight you need to stay ahead of the game all season long.

NFL odds used for these Week 1 ATS picks are courtesy of DraftKings Sportsbook and current as of Thursday, Sep. 4.

NFL Week 1 ATS Picks

Edit
Week 1The Game Day
DAL @ PHI (-8.5)PHI
KC (-3) @ LACKC
CIN (-5.5) @ CLECIN
NYG @ WAS (-6)NYG
ARI (-6.5) @ NOARI
PIT (-3) @ NYJNYJ
TB (-1.5) @ ATLATL
MIA @ IND (-1.5)MIA
CAR @ JAC (-3.5)CAR
LV @ NE (-2.5)LV
TEN @ DEN (-8.5)DEN
SF (-2.5) @ SEASEA
DET @ GB (-2.5)GB
HOU @ LAR (-3)LAR
BAL (-1.5) @ BUFBAL
MIN (-1.5) @ CHIMIN
Best BetARI -6.5

We’re riding with several road teams this week, including the Cardinals and Bengals in exploitable matchups. It will be interesting to see if the Ravens can get it done as road favorites in a potential AFC Championship preview vs. the Bills. There are also several other intriguing divisional games, like Vikings vs Bears and Lions vs Packers.

Sportsbook Play of the Day

NFL Week 1 ATS Best Bets

Cardinals -6.5 (-110) @ Saints

You might be shocked to see the Cardinals as such heavy road favorites given how average they’ve been under Jonathan Gannon, but that’s how bad the Saints are this year.

The Cardinals have an improving defense that is likely going to cause issues for Rattler, even in this road game.

Add in an offense that still has some nice pieces like Kyler Murray, Marvin Harrison Jr, Trey McBride, and James Conner. You can see how the Cardinals have the edge in this game. Don’t be surprised if they win by double-digits.

Bengals -5.5 (-110) at Browns

The Bengals came on strong in the second half last season, but wound up falling just short of the playoffs. Why? Because they threw away a Week 1 game against the Patriots last year.

Judging by the way the team decided to play their starters more in preseason, it’s clear that avoiding a slow start was a point of emphasis for Cincinnati this season.

Even with Joe Flacco under center, the Browns project to be one of the worst teams in the NFL. Don’t overthink this one. Ride with Joe Burrow and company in a game where they should have their way with this defense.

NFL Odds Against the Spread

Before making your football bets today, use our odds comparison tool to ensure you get the best ATS odds and betting lines:

Author

TGD Staff

The Game Day's betting and fantasy sports analysts bring you 20+ years of experience.

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