Colts vs Patriots Predictions & Odds

Last Updated: Oct 31, 2022

After making the move to start Sam Ehlinger at quarterback, the Colts suffered an all-time let-down loss against the Commanders this past Sunday. There were some encouraging signs, but the loss stings nonetheless.

On the other hand, the Patriots — led by their defense — took down the Jets to move to 4-4 on the season.

How will this week’s outing between the Colts and Patriots turn out? Continue reading for my Indianapolis vs New England best bets and predictions.

Colts vs Patriots Odds

As of Monday at BetMGM Sportsbook, the Colts are listed as 5.5-point underdogs at New England. The total is set at a measly 39.5 points, which is understandable given the state of these offenses.

Take a look at the best Colts odds and Patriots odds for the 2022 NFL season.

Colts vs Patriots Implied Totals

Patriots 22.5, Colts 17

The oddsmakers have the Patriots winning a low-scoring game by just under a touchdown. Between Mac Jones and Ehlinger, there likely won’t be many touchdowns to speak of here.

Colts vs Patriots Pick of the Day

Read more on this Colts vs Patriots bet below.

Colts vs Patriots Prediction

Patriots 20, Colts 16

The Colts-Commanders game was pretty rough last week, but this matchup should at least be marginally better.

Ehlinger completed an impressive 73.9% of his passes for 201 yards in Indy’s loss, and he threw some nice deep balls as well. It was an encouraging performance for a team that has gotten nothing but underwhelming starts at the position this year.

The Patriots have also gotten mediocre play from their quarterbacks this season, though Bailey Zappe has looked solid in comparison to Jones, the incumbent starter. Still, Jones is expected to get the nod again against the Colts.

Running back Jonathan Taylor should keep the Colts in this one until the end, but it is important to note that New England has given up the fourth-fewest rushing touchdowns in the league this year. Indianapolis may need to score a couple times through the air to win this one, and I just don’t see that happening.

Colts vs Patriots Bet Tips

Here are some Colts vs Patriots betting trends to consider before placing your bets:

  • The Colts are 3-5 against the spread; the Patriots are 4-3-1.
  • Unders are 7-1 in Colts games this season and 4-4 in Patriots games.
  • The Colts haven’t won in New England since November 2006.

Colts vs Patriots Best Bets

Under 39.5 Points (-110) at BetMGM Sportsbook

This is the lowest total on the board this week. Still, I like the Under to hit in this one. The Colts have the third-lowest scoring offense in the league, and the Patriots are average at best on that side of the ball.

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Colts +5.5 (-110) at BetMGM

This offense is rough, but the Patriots don’t have the firepower to outscore the Colts that dramatically — especially in a low-scoring game like this one. Expect Indy to ultimately lose a close one.

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Colts vs Patriots Props

Check out the best Colts vs Patriots player prop bets this week with our props comparison tool. Click on Indianapolis vs New England game below to see all of its prop bets.


Garrett Chorpenning

Garrett Chorpenning is the Lead NBA Editor for The Game Day. His previous work includes covering the LA Clippers for Sports Illustrated and FanSided. He graduated from Ball State University in 2021.

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