Cardinals vs Steelers Predictions & Best Bets

Last Updated: Dec 1, 2023

Week 13 of the NFL has plenty of meaningful games, and this matchup between the Arizona Cardinals and Pittsburgh Steelers has two teams with very different narratives surrounding their season.

Can the Steelers hold off a Cardinals club looking to notch their first win with QB Kyler Murray back in the fold? Check out the analysis of this game and other NFL Week 13 predictions to get all the best betting insight.

Cardinals vs Steelers Odds

NFL odds used for this Arizona vs Pittsburgh preview were found at FanDuel Sportsbook and are current as of date and time ET.

  • Moneyline: Steelers (-255) • Cardinals (+210)
  • Spread: Steelers -5.5 (-114) • Cardinals +5.5 (-106)
  • Total Points: Over 41.5 (-105) • Under 41.5 (-115)
  • Implied Score: Steelers 23.5, Cardinals 17.5

Cardinals vs Steelers Predictions

Score Pick: Steelers 20, Cardinals 17

While the Pittsburgh Steelers haven’t looked great on the field, they continue to escape with victories this season. Against an Arizona team that is 2-10 and battered with offensive injuries, there should be an opportunity for the Steelers to pull away again with a win.

The run game has improved in recent weeks for the Steelers, and the Cardinals have allowed the second-most rushing yards this season. Expect this to be a low-scoring affair, but that’s when Pittsburgh seems to be at its best.

Cardinals vs Steelers Best Bets & Props

Najee Harris Over 52.5 Rushing Yards (-114)

FanDuel Sportsbook • WAGER: 2 units

Najee Harris has held off Jaylen Warren as the team’s lead back up to this point in the season, and coming off of a 99-yard game against Cleveland, he likely keeps the majority of the carries. Making the over here our NFL Bet of the Day!

In his last six contests, Harris has surpassed 52.5 four times, and against a poor run defense like Arizona, he should do so once again.

The Cardinals have allowed 143, 112, and 95 rushing yards in their last three games. Expect the Steelers to get both backs plenty of opportunities.

James Conner Over 54.5 Rushing Yards (-110)

bet365 Sportsbook • WAGER: 1 unit

The Pittsburgh defense has been phenomenal against the run lately, limiting their last two opponents’ lead rushers to 52 total yards rushing. However, that number is skewing the lines set for James Conner.

The past two games for the Steelers were nothing to scoff at, but they were against very limited passing offenses. While Kyler Murray hasn’t been perfect since his return, he should open the offense enough to get Conner some space to produce and pass this number against his former team—a line he’s outperformed in two of his three games since returning from injury.

Kenny Pickett Interception: No (-130)

DraftKings Sportsbook • WAGER: 1 units

While some have been underwhelmed with Kenny Pickett up to this point in the season, he has done a great job cutting down on his turnovers. Pickett has gone seven straight contests without one after four interceptions in his first four games of this season.

The Cardinals are in the bottom half of the league when it comes to interceptions, and the game script indicates the Steelers will try to focus on winning with their rushing attack. With limited throws, Pickett should be able to end the game without throwing one to the other team.

Cardinals vs Steelers Same Game Parlay

Cardinals vs Steelers SGP (+408)

FanDuel Sportsbook • WAGER: 1.5 units

  • Najee Harris - Over 52.5 Rushing Yards (-114)
  • Steelers (-255)
  • Under 41.5 (-115)
  • Diontae Johnson - Alt Receiving Yards: 25+ (-490)

The Steelers should control this one, but expect it to be a low-scoring affair. With Najee Harris remaining the lead back, he should surpass this number, while the rest should fall in order.

The Diontae Johnson leg is added after the receiver apologized for his effort in Week 12. A productive game seems like a good way to get the forgiveness he is seeking, but with the limited opportunities in the Pittsburgh offense, 25+ is a safe expectation.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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