Vikings vs Bills Predictions & Odds

Last Updated: Nov 8, 2022

In what could be a preview of the 2023 Super Bowl, the Buffalo Bills will host the Minnesota Vikings in Week 10.

While the Bills lost to the Jets last week, dropping their record to 6-2, the Vikings remain red-hot and enter this matchup coming off a come-from-behind road win over the Commanders, lifting their record to 7-1.

Here are my Minnesota vs Buffalo NFL best bets and betting tips for Week 10.

Vikings vs Bills Odds

The Vikings are six-point underdogs to the Bills as of Tuesday morning at Caesars Sportsbook, despite having a better record.

It may be wise to jump on the Vikings to cover early considering Josh Allen could be dealing with an elbow injury that could impact the line as the week progresses.

Take a look at the best Vikings odds and Bills odds for the 2022 NFL season.

Vikings vs Bills Implied Totals

Bills 26, Vikings 20

While the Bills are averaging 27.5 points per game, their total falls just short, likely representing a potential injury to Allen’s elbow that could impact his play on the field.

The Vikings are scoring 24.1 ppg, but they are up against the Bills’ No. 1 scoring defense, which concedes just 14.8 ppg. Their implied total reflects this and the fact that are on the road.

Vikings vs Bills Pick of the Day

Read more on this Vikings vs Bills bet below.

Vikings vs Bills Prediction

Bills 27, Vikings 24

As of this wiring, there is no update on Josh Allen’s elbow. While the oddsmakers are still favoring the Bills at home, this injury could affect Allen’s onfield play even if he is active.

Allen is not the only injury news for the Bills. They will enter Week 10 banged up, notably on defense. While Tre’Davious White and Matt Milano are both on the injury report with day-to-day injuries, Jordan Poyer, Greg Rousseau, and Xavier Rhodes are sidelined indefinitely.

Meanwhile, the Vikings will enter this matchup about as healthy as a team can be for Week 10 of an NFL season.

The key to this game will be the Vikings’ offense being able to keep up with the Bills’ scoring, especially against the stout Buffalo defensive unit.

The Bills have the No. 1 offense in total yards while the Vikings are 25th in that category defensively. Furthermore, the Buffalo defense should be able to make the Minnesota offense one-dimensional. The Bills’ defense is allowing the sixth-fewest rushing yards while the Vikings have the ninth-worst mark.

This game will be Allen versus Kirk Cousins. It may be one of those games where the team with the ball in their hands last, wins.

Vikings vs Bills Bet Tips

Here are some Vikings vs Bills betting trends to consider before placing your bets:

  • The Under is 6-0 in the past six games the Bills have played overall.
  • The Under is 4-0 in the past four games the Bills have played against teams with a winning record.
  • The Vikings have won six straight games and are 2-0-1 against the spread in their past three games overall.
  • The Under is 2-1 in the past three games the Vikings have played overall.
  • The Bills are 2-3-1 ATS in their past six games, failing to cover in two straight.

Vikings vs Bills Best Bets

Vikings +6 (-110) at Caesars Sportsbook

If you want to take the value, anticipating that Josh Allen’s elbow injury is severe, you can take the Vikings to win outright at (+215) odds. However, playing it safe may be the best way to go as the 7-1 Vikings are getting six points on the road against a Bills team that is banged up on both sides of the ball.

We have seen the Vikings play well on the road this season, picking up three straight road wins. This should be an easy cover for Minnesota.

Before placing this bet, get the best Vikings promo codes.

Under 46 Total Points (-110) at Caesars Sportsbook

While both of these offenses can score the football, each of the Bills’ past six games have gone Under, including each of their past four against teams with a winning record. Two of those games were at home.

Before placing this bet, get the best Bills promo codes.

Vikings vs Bills Props

Check out the best Vikings vs Bills player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Minnesota vs Buffalo game and see all of its prop bets.


Anthony Cervino

Anthony Cervino is an NFL Writer and Betting Analyst for The Game Day. He is also a lifelong NFL savant and self-proclaimed league historian. In the industry, Anthony has excelled in both the fantasy football and sports betting space with fantasy his proverbial bread and butter. Anthony has made appearances on SiriusXM, amongst other publications. He is also the co-creator of the FF Faceoff (Faceoff Sports Network) and the FF Faceoff Mental Health Podathon partnered with the Hayden Hurst Foundation. Industry Clout: 15th most accurate ranker in the FantasyPros ECR for both draft and in-season accuracy (2019) | 8th most accurate ranker in the FantasyPros ECR for sleepers (2020) | 13th most accurate ranker in the FantasyPros ECR for in-season accuracy, including 2nd at quarterback and 3rd at tight end (2021).

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