Bills vs Bears Predictions & Odds

Last Updated: Dec 20, 2022

The Buffalo Bills (10-3) will look to extend their five-game winning streak when they travel to Chicago to take on the Bears (3-11) on Christmas Eve.

The Bills clinched a playoff berth with a 32-29 comeback win over the Miami Dolphins last Saturday night. A win this week against Chicago will earn Buffalo its third consecutive AFC East title.

Chicago will look to avoid its eighth straight loss on Saturday after suffering a 25-20 defeat to the Philadelphia Eagles last weekend. The Bears’ defense has conceded at least 25 points in seven losses and has allowed the sixth most rushing yards of any team in the league this season.

Let’s dive into our Buffalo vs Chicago best bets and predictions for this Week 16 showdown.

Bills vs Bears Odds

As of Tuesday, Dec. 20, Caesars Sportsbook rightfully has Buffalo as a heavy favorite despite playing on the road.

The Bears’ offense has put up a fight in many games this season. The 40.5-point total seems low for how good both offenses can be at full strength. However, the weather forecast will certainly play a role in how both teams perform.

Take a look at the best Bills odds and Bears odds for the 2022 NFL season.

Bills vs Bears Implied Totals

Bills 24.75, Bears 15.75

Oddsmakers are predicting a relatively low-scoring affair for this game despite both offenses showcasing high-octane capabilities this season. Meteorologists are predicting a major blizzard to pass through the Chicago area this week and near-zero temperatures could have a big effect on this game.

While Buffalo did manage to put up 32 points in a snowy game last weekend, the weather is expected to be far worse and conditions may be much more difficult to play in.

Should the weather worsen, you could expect the point total to drop even further in this contest.

Bills vs Bears Pick of the Day

Read more on this Bills vs Bears bet below.

Bills vs Bears Prediction

Bills 24, Bears 15

Sean McDermott and the Bills have their eyes set on the ultimate prize in professional football this season. After an uncharacteristic start to the year, Buffalo is now back in the driver’s seat and will seize the opportunity to clinch the division against the Bears on Saturday.

Josh Allen proved why he is amongst the upper echelon of quarterbacks with a big-time comeback against his division-rival Dolphins last weekend. Allen completed 24-of-40 passes for 304 yards and four touchdowns. The superstar quarterback also led his team on the ground with 10 carries for 77 yards.

Allen’s favorite target last week was tight end Dawson Knox, who finished with six receptions for 98 yards and a touchdown. McDermott also got solid contributions from some uncharacteristic players, with James Cook, Nyheim Hines, and Quintin Morris each catching a touchdown. The versatility on offense will certainly be enough to overpower a weak Chicago defense.

The Bears fell just short against the top-seeded Eagles last Sunday despite another great performance from sophomore quarterback Justin Fields. Fields has made strides from his rookie season and has played exceptionally well despite Chicago’s poor record.

The former Ohio State Buckeye finished last week’s game with 152 passing yards and two touchdowns. He also led the team with 15 carries for 95 yards on the ground, and became only the third quarterback to have a 1,000-yard rushing season in NFL history.

Chicago’s defense has been its biggest issue this season and last week was another example of why. Eagles receivers A.J. Brown and Devonta Smith finished with nine catches for 181 yards and five catches for 126 yards, respectively.

While Saturday’s game may not be as pass-heavy due to the weather, the overall play of the defense this season is surely a point of concern for first-year head coach Matt Eberflus with Allen and co. coming to town.

Bills vs Bears Bet Tips

Here are a few Bills vs Bears betting trends to consider before making your bets:

  • The Bills are 6-7-1 against the spread, including 4-6 after a win, and 3-3-1 as the away favorite.
  • The Bears are 5-8-1 ATS, including 4-5-1 after a loss and 3-3-1 at home.
  • The Over is just 4-10 in Bills games and 0-7 in their away contests.
  • The Over is 9-5 in Bears games, including 4-3 in their home contests.

Bills vs Bears Best Bets

Under 40.5 Points (-110) at Caesars Sportsbook

WAGER: 1 Unit

The weather will be the ultimate factor when it comes to the point total in this game. It will be interesting to see how the line moves as the forecast becomes more of a sure thing later in the week.

Despite both offenses performing exceptionally well in recent weeks, a snowstorm will serve as the ultimate deterrent in these teams scoring points.

Want to bet on the Bills? Check out the best NY sportsbooks!

Bears +10 (-135) at Caesars Sportsbook

WAGER: 1 Unit

The Bears have put up a fight against some of the top teams in the league this season despite such a bad record. With the weather conditions certain to play a role in how both teams approach this game, Buffalo jumping out to a big lead seems unlikely.

Fields and the Bears’ offense won’t upset the Bills, but can certainly make this game competitive when it’s all said and done.

Want to bet on the Bears? Check out the best IL sportsbooks!

Bills vs Bears Props

Check out the best Bills vs Bears player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Buffalo vs Chicago game and see all of its prop bets.


Anthony Blanco

Related articles


Welcome offer
Caesars Sportsbook

1st Bet on Caesars up to $1,250 + 2,000 in Rewards & Tier Credits

5 stars
Welcome offer
DraftKings Sportsbook

Bet $5 & Get $200 in Bonus Bets

5 stars
Welcome offer
bet365 Sportsbook

Bet $1 & Get $200 FREE

5 stars
Welcome offer
FanDuel Sportsbook

Get $1,000 No Sweat First Bet

5 stars
Welcome offer
BetMGM Sportsbook

Get up to a $1,000 First Bet Offer Bonus

5 stars
Welcome offer
Tipico Sportsbook

Get Up to a $100 Bonus

5 stars
Welcome offer
BetRivers Sportsbook

Get up to $500 2nd Chance Free Bet

5 stars
Welcome offer
WynnBET Sportsbook

Bet $100 & Get a $50 Free Bet + a $50 Casino Bonus

5 stars
Welcome offer

Get Up To $50 First Bet on FOXBet

5 stars