Buccaneers vs 49ers Predictions & Odds

Lance PattonPromotions Creator & Editor
Last Updated: Dec 11, 2022

The Jimmy Garoppolo-less San Francisco 49ers will seek their sixth-straight win when they host the Tampa Bay Buccaneers in Week 14.

San Francisco leaned on the league’s best defense and Christian McCaffrey to beat the Dolphins 33-17 in Week 13 and now hold one-game lead over the Seahawks in the NFC West.

Tampa Bay had a miraculous comeback to beat the Saints, scoring two touchdowns in the final three minutes to overcome a 16-3 deficit and effectively keep their season alive. With the win, the Buccaneers improved to 6-6 and now hold a two-game lead in the NFC South.

Continue reading for NFL Week 14 odds, predictions, and best bets for the Tampa Bay Buccaneers vs San Francisco 49ers.

Buccaneers vs 49ers Odds

The Bucs have struggled as of late, but even without Jimmy Garoppolo, the 49ers are a 3.5-point favorite at home as of Tuesday afternoon at Caesars Sportsbook.

The total of 37.5 is one of the lowest of the week. Considering the offensive struggles of Tampa Bay and Mr. Irrelevant Brock Purdy making his first NFL start, this isn’t a big surprise.

Take a look at the best Buccaneers odds and 49ers odds for the 2022 NFL season.

Buccaneers vs 49ers Implied Totals

49ers 20.5, Buccaneers 17

The oddsmakers expect the 49ers to get the win at home over the Buccaneers. With Tampa Bay’s struggles on the road and the 49ers’ success at home, it’s no shock they’re a favorite, even with a backup quarterback.

Buccaneers vs 49ers Pick of the Day

Read more on this Buccaneers vs 49ers bet below.

Buccaneers vs 49ers Prediction

Buccaneers 17, 49ers 13

Despite a miraculous comeback win in Week 13, the Bucs have major issues on the offensive line and coaching staff. The play-calling has been more conservative — partially out of necessity — as a banged-up offensive line has struggled to block anyone this season.

The normally razor-sharp Tom Brady has looked just a bit off this season, frustrated with young players making mistakes and the lack of protection from the offensive line. Despite this, the Bucs sit atop the NFC South by 1.5 games and are in prime position to make the playoffs.

Still, Tampa Bay is going to have their hands full this week against the NFL’s No. 1 defense. The 49ers surrender just 15.8 points and 283.9 yards per game, in large part thanks to their dominant front seven.

Joey Bosa leads the NFL in sacks with 14.5, and Dre Greenlaw and Fred Warner are arguably the best linebacker duo in the NFL.

Both teams will likely struggle to generate points in this one, especially the 49ers, who are starting rookie Brock Purdy behind center. As a backup, Purdy’s appeared in four games this season, throwing for 276 yards and two touchdowns.

Buccaneers vs 49ers Bet Tips

Here are a few Buccaneers vs 49ers betting trends to consider before making your bets:

  • San Francisco has won five straight games, and covered the spread in four of those wins.
  • The total has gone Over in San Francisco’s last four games.
  • The oddsmakers are not putting much stock in Jimmy Garoppolo’s injury and Brock Purdy’s first start.
  • Tampa Bay is 1-8-1 against the spread in their last 10 games.

Buccaneers vs 49ers Best Bets

Buccaneers +4 (-110) at PointsBet Sportsbook

WAGER: 1 Unit

I think both teams will struggle to score in a close, low-scoring affair, so I’ll take the Bucs getting four points facing a backup quarterback.

Last week’s comeback win might be exactly what the Bucs needed to turn their season around, but they’re still bound to struggle against this 49ers defense.

Even so, four points seem like a lot to give a desperate Brady and Bucs team facing a rookie quarterback making his first start.

Before placing this bet, get the best Buccaneers promo codes.

Under 37.5 Total Points (-110) at Caesars Sportsbook

WAGER: 1 Unit

Two solid defenses and two offenses with problems laced all over the field.

The Bucs’ defense has the speed and skill to contain Christian McCaffrey, and even a banged-up secondary should be able to keep rookie Brock Purdy from beating them down the field.

The Bucs have gone far more conservative offensively and seem happy to string together long, time-consuming drives.

This game is won by the defenses, and the defenses do enough to keep this total Under.

Before placing this bet, get the best 49ers promo codes.

Buccaneers vs 49ers Props

Check out the best Buccaneers vs 49ers player prop bets this week with our props comparison tool. Click on “Show More Games" below to find the Tampa Bay vs San Francisco game and see all of its prop bets.


Lance Patton

Lance Patton is the Promotions Creator & Editor for The Game Day and also creates content for the NFL, college football, and college basketball. Before joining The Game Day, Lance did freelance work for a variety of sports betting websites as well as covering the Iowa Hawkeyes for FanSided.

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