NFL Week 11 Odds & Opening Lines

Last Updated: Nov 14, 2022

Week 11 brings us into the second half of November, which means things are really starting to get serious.

Last week’s slate featured a number of outright upsets that resulted in a major shakeup of the AFC playoff picture. The Chiefs are now the No. 1 seed, and if the season ended today, the entire AFC East would make the postseason.

We’ve got 14 more games in store for this week, including a crucial clash between the Jets and Patriots in that division race, and I’m here to break them all down and help you get some early-week value.

Here are the current Week 11 NFL odds and lines for the 2022 season.

Week 11 NFL Odds & Lines

Week 11 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Nov. 14, at 11 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 11.

Week 11 NFL Games

Tennessee Titans @ Green Bay Packers (Thursday Night Football)

Titans +2.5 (-104) @ Packers -2.5 (-118)

The Packers finally snapped their five-game losing streak Sunday, but Green Bay won’t have much time to celebrate before hosting the Titans on Thursday night.

Can Aaron Rodgers lead his team to another much-needed victory? Or will Derrick Henry run all over this Packers’ defense and help Tennessee to another ugly win?

I don’t know what to make of either team, so staying away seems smart.

Chicago Bears @ Atlanta Falcons (Nov. 20, 1 p.m. ET)

Bears +3 (-110) @ Falcons -3 (-110)

Bears quarterback Justin Fields has put up ridiculous numbers over the past few weeks, but they haven’t translated to victories for Chicago. Atlanta should be able to move the ball at will against a porous Bears defense, and the Falcons have a rest advantage after playing on Thursday night.

Still, laying three points with this team is a lot to ask.

Carolina Panthers @ Baltimore Ravens

Panthers +10.5 (-105) @ Ravens -10.5 (-115)

The Panthers may be coming off a win on Thursday night, but they’re also going back to Baker Mayfield at quarterback after P.J. Walker sprained his ankle in the 10-point win over Atlanta.

Meanwhile, the Ravens are coming off a bye and could get some key pieces back from injury. Baltimore is typically good at covering these large spreads against bad teams, but I’d probably wait until we know more about the status of Mark Andrews later in the week.

Cleveland Browns @ Buffalo Bills

Browns +9.5 (-110) @ Bills -9.5 (-110)

Josh Allen (elbow) appeared to be healthy in Sunday’s 33-30 loss to the Vikings, however, Buffalo’s recent second-half woes continued as the Bills scored just six points after the interval. Meanwhile, Cleveland was blown out in Miami, but the Browns should have success on the ground in this matchup.

I’d lean toward taking Cleveland and the points, but I’d wait to see which way this line moves.

Washington Commanders @ Houston Texans

Commanders -2.5 (-114) @ Texans +2.5 (-106)

Backing the Commanders has been a successful venture since Taylor Heinicke replaced Carson Wentz as the team’s starting quarterback, however, this is a matchup where the Texans’ putrid rush defense may not be exposed.

If this line gets to three or higher, I’d be tempted to back Davis Mills and the Texans at home.

Philadelphia Eagles @ Indianapolis Colts

Eagles -8.5 (-114) @ Colts +8.5 (-106)

This is a sell-high spot on the Colts, who pulled off the surprise upset on Sunday against the Raiders. Unlike Las Vegas, this Eagles’ team is well-coached and will have the advantage of knowing that Matt Ryan is likely Indy’s starting quarterback.

Teasing the Eagles down is the most prudent play, but I’d still feel pretty comfortable backing Philly as a favorite of less than 10.

New York Jets @ New England Patriots

Jets +3.5 (-115) @ Patriots -3.5 (-105)

The Patriots have won 13 straight games against the Jets, and haven’t lost to their AFC East rival in Foxborough since Jan. 16, 2011. New York fans will remember that day fondly, as the Mark Sanchez-led Jets advanced to the AFC Championship with a 28-21 win, punctuated by Bart Scott’s famous post-game “Can’t Wait" rant.

There are still plenty of “non-believers" in the 2022 Jets, but I’m backing Robert Saleh‘s squad to pull out an equally gutsy win on the back of its defense. Taking three and the hook with the visitors is the play.

Los Angeles Rams @ New Orleans Saints

Rams +3 (-114) @ Saints -3 (-106)

These teams are a mess.

The Saints have lost four of their last five, while the Rams have dropped five of six and may be without star wideout Cooper Kupp (ankle) for an extended period of time.

I’d probably lean toward the Saints at home, but there are better ways to spend your hard-earned money.

Detroit Lions @ New York Giants

Lions +3.5 (-115) @ Giants -3.5 (-105)

This line is fishy.

The Lions have won back-to-back games and are catching three and the hook against a Giants team that no one trusts to be a legitimate contender.

I think Detroit will be the popular side, but Saquon Barkley should have another big day against this Lions’ defense. I’d wait for this line to drop to three before backing New York.

Las Vegas Raiders @ Denver Broncos (Nov. 20, 4:05 p.m. ET)

Raiders +2.5 (+100) @ Broncos -2.5 (-122)

I’ve been burned by each of these teams one too many times to have any interest in betting on this matchup.

The Raiders won the first meeting between these two teams 32-23 back in Week 4, but who knows what kind of effort you’re going to get from either side after a pair of demoralizing losses on Sunday.

Cincinnati Bengals @ Pittsburgh Steelers

Bengals -4.5 (-110) @ Steelers +4.5 (-110)

After a bye week, the Bengals head to Pittsburgh with hopes of avenging their 23-20 Week 1 defeat to their AFC North rival. The key question will be whether or not Cincinnati can figure out how to block T.J. Watt, who returned to action in the Steelers’ 20-10 victory over the Saints on Sunday.

If the Bengals’ offensive line can protect Joe Burrow, Cincinnati should win this game. That’s a big if, and I don’t feel comfortable enough laying this many points with the road team.

Dallas Cowboys @ Minnesota Vikings

Cowboys -1.5 (-110) @ Vikings +1.5 (-110)

That’s not exactly the spread I was expecting to see after Sunday’s results. I do, however, want to back Dallas in this spot. The Vikings are coming off an emotional win in the NFL’s game of the year, while the Cowboys dropped an overtime heartbreaker to the Packers.

Dak Prescott should have plenty of success through the air, while Dallas’ defense puts the pressure on Kirk Cousins.

Kansas City Chiefs @ Los Angeles Chargers (Sunday Night Football)

Chiefs -7 (-106) @ Chargers +7 (-114)

The league made the decision to move this game into the primetime slot, meaning the Chargers will play back-to-back weeks on Sunday Night Football. The important question for Los Angeles is whether Justin Herbert will have anyone to throw to by the time this game kicks off, as injury issues continue to mount in the Chargers camp.

The last three meetings between these teams have been decided by less than seven points, but this feels like an opportunity for Patrick Mahomes and the Chiefs to flex their muscle.

San Francisco 49ers @ Arizona Cardinals (Monday Night Football)

49ers -7.5 (-110) @ Cardinals +7.5 (-110)

Colt McCoy has proven over the years that he can keep the Cardinals in games when called upon. He, and a pair of James Conner touchdowns, helped Arizona knock off the Rams Sunday, but this 49ers squad is a much tougher test.

San Francisco is a great teaser piece, but I wouldn’t lay the points with the Niners until we know more about Kyler Murray‘s injured hamstring.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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