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NFL Week 11 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 31, 2022

At about this time in the calendar, football starts to get more important.

While many of the games on the Week 11 slate are intriguing, none are as intriguing, at least on paper, as Chiefs-Chargers on Sunday afternoon. If you like young, talented quarterbacks, this is the game for you.

But it is not alone.

Here are the current Week 11 NFL odds and lines for the 2022 season.

Week 11 NFL Odds & Lines

Week 11 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Friday, Aug. 12 at 4 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 11.

Week 11 NFL Games

Tennessee Titans @ Green Bay Packers (Thursday Night Football)

Titans +4.5 (-110) @ Packers -4.5 (-110)

In many ways, this game is more about who isn’t in the lineup. Wideouts A.J. Brown and Davante Adams are now on new teams, which means both Tennessee and Green Bay will need to find new weapons.

Green Bay was not particularly strong against the run last year, which could be an issue if Tennessee running back Derrick Henry is healthy. The reality, however, is that Aaron Rodgers vs Ryan Tannehill feels like a gargantuan mismatch this week and any week.

I’m laying the points.

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Chicago Bears @ Atlanta Falcons (Nov. 20, 1 p.m. ET)

Bears PICK (-110) @ Falcons PICK (-110)

Although neither team is likely to make the playoffs, this game isn’t short on intrigue. Both the Bears and the Falcons are searching for, well, anything, and this is likely to be competitive.

The fact that this game is listed at pick ’em is a good sign for the Bears. Chicago is likely to be better across the board, although how will it handle tight end Kyle Pitts, who seems primed for a monster season?

Both teams have questions, although Chicago might have more answers. I lean toward the Bears.

Carolina Panthers @ Baltimore Ravens

Panthers +5.5 (-105) @ Ravens -5.5 (-115)

For quarterback Baker Mayfield, this matchup should feel familiar. Although he has changed teams, he knows plenty about playing in Baltimore. It hasn’t always gone well, as he has a record of 3-5.

This could be different, and a healthy Carolina feels like a nice option with the points. As long as running back Christian McCaffery and cornerback Jaycee Horn can stay on the field, the Panthers can keep this close.

Washington Commanders @ Houston Texans

Commanders -3 (-110) @ Texans +3 (-110)

This is not a game the football universe is craving, although it will be handed it regardless. And the focus, whether it’s a good thing or not, will be on the quarterbacks.

Davis Mills and Carson Wentz are set to duke it out, assuming both are healthy. And strangely, it seems possible that Mills might be in a better position to thrive. The Texans have quietly added some nice pieces, and it will show up in a game like this.

I’m gladly taking the points at home.

Philadelphia Eagles @ Indianapolis Colts

Eagles +3 (-120) @ Colts -3 (+100)

The Eagles have about as much buzz as any team in football, although it might be worth slowing down the bus some. Sure, Jalen Hurts should be fine, and the addition of some offensive pieces will help.

But Matt Ryan is an enormous upgrade for Indy at quarterback, and I especially like this team playing at home. While Philly has invested a lot upfront on defense, Jonathan Taylor and Indy feel like a play here as only a field goal favorite.

New York Jets @ New England Patriots

Jets +6 (-110) @ Patriots -6 (-110)

Last season, the Jets scored 19 combined points against New England in 120 minutes of football. The Patriots, meanwhile, accounted for 79 points.

Although New York is overhauling its roster, we still have a wealth of questions about quarterback Zach Wilson after another injury. While the trajectory of the Jets is pointed upward, this doesn’t feel like a particularly good spot.

New England feels like it’s still at least a touchdown better at home.

Los Angeles Rams @ New Orleans Saints

Rams -3 (-110) @ Saints +3 (-110)

If the Chiefs or Chargers falter, this could very well end up being the best game on the slate. The Super Bowl champs will hit the road to play against a great defense in a difficult environment, and they will do so between games against the Cardinals and the Chiefs.


The Saints have questions on offense, but home-field advantage (and points) are just too much to pass up here.

Detroit Lions @ New York Giants

Lions +1.5 (-110) @ Giants -1.5 (-110)

Dan Campbell, Hard Knocks darling, will have one of his better chances to win a football game in this spot. The emotional heartbeat of the Lions might also have a batch of nice players on its hands, headlined by running back D’Andre Swift and wideout Amon-Ra St. Brown.

Although the Giants are a small favorite at home, this feels like an interesting spot for the feisty road dog.

Las Vegas Raiders @ Denver Broncos (Nov. 20, 4:05 p.m. ET)

Raiders +3 (+100) @ Broncos -3 (-120)

This will mark the second and final time the Broncos and Raiders meet, which feels like a pivotal game for two potential playoff teams.

Las Vegas won both matchups last year, although this note feels invalid now that Russell Wilson is in Denver. The Raiders didn’t add a superstar quarterback, although they did add one of the greatest wideouts of our generation.

Even in a tough place to play, Las Vegas feels like a steal as a field-goal dog.

Kansas City Chiefs @ Los Angeles Chargers

Chiefs +1.5 (-110) @ Chargers -1.5 (-110) 

The game of the week (and one of the games of the year) headlines the afternoon slate. Patrick Mahomes vs Justin Herbert is must-see TV until further notice.

Last year, the Chiefs won a close game early in the season at home. The location flips this time around, and Los Angeles has gotten significantly better. Expect Mahomes to be under an abundance of pressure, and for the Chargers to cover the small number.

Back Los Angeles as your NFL pick of the day.

Dallas Cowboys @ Minnesota Vikings

Cowboys PICK (-110) @ Vikings PICK (-110) 

One week after traveling to Green Bay, the Cowboys head back north to Minnesota. That is not an easy one-two punch, and the Vikings could present a problem here.

Last year, Minnesota lost to Dallas 20-16 in Minneapolis. It’s worth noting that quarterback Dak Prescott was out of that game. A year later, the Vikings should do one better. The lack of roster improvement from Dallas comes back to bite them here.

Cincinnati Bengals @ Pittsburgh Steelers (Sunday Night Football)

Bengals -2.5 (-110) @ Steelers +2.5 (-110)

Who will be playing quarterback for the Steelers by the time this game is played? That is the question.

Given the momentum he’s garnered in the preseason, Kenny Pickett feels like the answer. The rookie QB has shown flashes.

It might not matter, though, as Cincinnati outscored Pittsburgh 65-20 last season, and the gap between these two teams hasn’t gotten smaller. Although it’s a tough place to play, 2.5 feels like a gift.

San Francisco 49ers @ Arizona Cardinals (Monday Night Football)

49ers -2 (-110) @ Cardinals +2 (-110)

It was about this point last year that the Cardinals’ season started to fall apart. Before then, Arizona beat San Francisco in both games. The 31-17 victory on the road was particularly impressive.

Given how little we know about Trey Lance, it seems a tad aggressive to have San Francisco as a road favorite in a huge spot. Sure, the 49ers’ roster is deep, but I’m willing to take points at home with the Cardinals given all the moving parts of the road team.


Adam Kramer

Adam Kramer is an NFL, college football, and gambling analyst for The Game Day. While college football has long been his calling, he’s also covered sports such as boxing, horse racing, and baseball at The Game Day and in other places. He’s also written for Bleacher Report, VSiN, and various other outlets over the past decade-plus.

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