NFL Week 18 Parlays Picks & Predictions | NFL Play of the Day

Last Updated: Jan 6, 2022

It was another great week for Frank, as he hit his longshot parlay in Week 17 to collect 14.8 units. I’ll be filling in for him in Week 18 as we look to end the season on a high note.

Let’s dive in to find my favorite parlay bets for Week 18 in the NFL pick of the day series.

Please note that all NFL gameday odds are courtesy of Caesars Sportsbook and are current as of 1:30 p.m. ET on Tuesday, January 4.

Best NFL Parlay Week 18

NFL Week 18 Top Parlay Picks

Wager: 2 Units To Win 11.62 Units (+581) at Caesars Sportsbook

  • Jacksonville Jaguars +15.5 Point Spread (-110) vs Indianapolis Colts
  • Houston Texans +10.5 Point Spread (-110) vs Tennessee Titans
  • Miami Dolphins +7 Point Spread (-115) vs New England Patriots

NFL Week 18 Parlay

Jacksonville Jaguars +15.5 Point Spread (-110) vs Indianapolis Colts

Get ready to hold your nose. After getting routed 50-10 as +15.5-point underdogs last week, we’re going back to the Jaguars this week at the same NFL gameday odds.

Sure, I could argue that it’s simply too many points, but Jacksonville proved last week that there’s no such thing for this abomination of a team. So why am I taking the Jags this week, you ask?

Well, this is purely a fade of a Colts squad that needs to win to get into the postseason. We’ve seen time and again that teams with something to play for in the final week or two of the NFL season get severely overvalued in the market. This is one of those occasions.

Sure, Jonathan Taylor could run rampant on Jacksonville like Damien Harris and Rhamondre Stevenson did last week, but if Trevor Lawrence doesn’t turn it over to give Indianapolis short fields, I like the Jaguars to keep it close this week.

By the way, the Colts also haven’t won in Jacksonville since September 2014. That includes being the only team to fall to the 1-15 Jaguars last season.


Sportsbook Play Of The Day

Before making your NFL Week 18 parlay picks, you should know that Caesars Sportsbook is one of the best around. Take advantage of Caesars’ outstanding welcome bonus which matches your first bet up to $1,001 (win or lose) when you use our promo code .

Check out Chris Wassel’s Caesars Sportsbook review for more information on this betting site, or continue reading for our Week 18 parlay predictions.

Houston Texans +10.5 Point Spread (-110) vs Tennessee Titans

Can you sense a theme here?

The Titans already locked up the AFC South title with a win over the Miami Dolphins in Week 17, but they can clinch a first-round bye and home-field throughout the postseason if they knock off the Houston Texans on Sunday.

Of course, the Texans have nothing to play for so this should be easy, right?


Houston has won two of its last three games and kept things close with a more desperate 49ers team last week. The Texans led 7-3 at half and trailed by just three entering the fourth quarter before San Francisco pulled away for a 23-7 win.

Davis Mills has certainly improved over the last month of the season and looks to have built up a strong rapport with top wideout Brandin Cooks.

The Houston defense gave Ryan Tannehill fits in the first meeting between these two teams this season, as he threw four interceptions and the Texans won 22-13 in Tennessee.

I’m not necessarily expecting another outright win here, but the Titans will want to win and keep as many players healthy as possible in the process. Houston can keep this close or get in the backdoor if necessary.

Miami Dolphins +7 Point Spread (-115) vs New England Patriots

We’ll round off our parlay with one more team playing for pride against a divisional opponent with something to gain.

The Dolphins were finally exposed in Week 17, falling 34-3 to the Titans in an ugly offensive showing that saw Tua Tagovailoa crumble back down to earth.

The Miami quarterback completed fewer than 50 percent of his passes, lost a fumble, and threw a relatively meaningless late-game interception as the Dolphins lost for the first time in two months.

Meanwhile, New England clinched a playoff berth in that 50-10 rout of Jacksonville and can reclaim the AFC East with a win and a Bills home loss to the Jets.

These two teams usually play each other pretty close, so a seven-point spread seems a bit inflated after last week’s results and the motivation factors for each team, especially given this game will be played in Miami.

The Dolphins beat the Patriots 17-16 in New England in Week 1 and while things will be different this time around, look for Tua and Brian Flores to try to end the year on a positive note.

This is too many points.

Tua Tagovailoa, QB, Miami Dolphins

Dolphins quarterback Tua Tagovailoa will look to rebound in Miami’s season finale against the New England Patriots. (Image: USA TODAY Sports)

NFL Week 18 Longshot Parlay Prediction

Wager: 2 Units To Win 14.2 Units (+710) at Caesars Sportsbook

  • San Francisco 49ers Moneyline (+170) at Los Angeles Rams
  • Pittsburgh Steelers Moneyline (+200) at Baltimore Ravens

NFL Week 18 Longshot Parlay

San Francisco 49ers Moneyline (+170) at Los Angeles Rams

This game features two teams that still have something to play for as the Rams can clinch the NFC West with a win, while the 49ers need a win, tie, or a Saints loss to reach the postseason.

With New Orleans visiting the Atlanta Falcons on Sunday, it’s very likely San Francisco will have to take matters into their own hands.

Jimmy Garoppolo could return this week, which would be a boost to the 49ers’ passing game against a tough Rams defense. Although Trey Lance wasn’t horrible in his first NFL start, facing Aaron Donald, Von Miller, and Jalen Ramsey is a big step up from the Texans’ defense.

Meanwhile, Los Angeles has already clinched its place in the playoffs and has been rolling of late, winning five straight games.

This is a good sell-high spot on a Rams team that hasn’t really blown the doors off teams of late and really struggles against the 49ers, having lost five straight to San Francisco in the regular season.

Rams Head Coach Sean McVay is also generally someone that doesn’t take chances with players in meaningless games, so it’ll be interesting to see if some starters sit or get a quick hook as the Packers have already locked up the NFC’s first-round bye.

Pittsburgh Steelers Moneyline (+200) at Baltimore Ravens

The Pittsburgh Steelers remained alive entering Week 18 with an emotional Monday Night Football win against the Cleveland Browns in Ben Roethlisberger’s final game at Heinz Field.

Pittsburgh’s postseason chances still aren’t the best as they need to beat the Ravens, have the Colts lose to the Jaguars, and avoid a Raiders-Chargers tie to return to the playoffs.

While this could certainly be a let-down spot for the Steelers, I’m going to back them here as the healthier team. We don’t know about Lamar Jackson’s status just yet, and while I expect him to play, the Ravens’ roster, in general, has been decimated by injuries all season long.

Baltimore has lost five straight games, four of which have come by two points or less, including a 20-19 loss to Pittsburgh in Week 13. I could see the Steelers eking out another close one here on the road.

Same Game Parlay Picks NFL Week 18

Wager: 2 Units to win 4.54 Units (+227) at Caesars Sportsbook

  • Minnesota Vikings Moneyline & Total Points Under 44.5

NFL Week 18 SGP

I’ll wrap things up here with a completely meaningless game between two NFC North foes coming off drastically different results in Week 17.

The Bears routed the lowly Giants 29-3 for their second straight win. The defense harassed Mike Glennon, forcing a pair of fumbles and two interceptions from the New York quarterback while holding New York to -10 total passing yards.

No, that’s not a typo.

Meanwhile, the Vikings were on the wrong end of a 37-10 beatdown from the Green Bay Packers as Sean Mannion couldn’t get much going on offense as a fill-in for Kirk Cousins (COVID-19). Cousins should return in Week 18, however, which is good news for Minnesota given his success in the 1 p.m. window.

I still think this Bears defense, led by standout pass-rusher Robert Quinn, should have some success in slowing the Vikings down, and I’m expecting plenty of regression from Chicago’s offense as they likely won’t be gifted the ball inside the opposition 25-yard line twice in the game’s first five minutes.

Take the Vikings and the under here as your NFL bet of the day.

Thanks for reading our NFL Week 18 Parlays Picks & Predictions! For more NFL Week 18 betting tips, check out our NFL bet of the day.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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