NFL Week 15 Parlays Picks & Predictions | NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Dec 20, 2021

It was a tough week in parlay betting. We were really close to a winning week, just missing out on our (+596) parlay because the Washington Football Team could not get it done. Time to keep it simple this week.

Let’s dive in to find my favorite parlay bets for Week 15 in the NFL pick of the day series.

Please note that all NFL gameday odds are from FOX Bet Sportsbook and are current as of 5:00 p.m. ET on Tuesday, December 14.

Best NFL Parlay Week 15

NFL Week 15 Top Parlay Picks

Wager: 5 Units To Win 9.40 Units (+188) at FOX Bet

  • Buffalo Bills Moneyline (-450) vs Carolina Panthers
  • Cleveland Browns Moneyline (-175) vs Las Vegas Raiders
  • San Francisco 49ers Moneyline (-400) vs Atlanta Falcons
  • Tampa Bay Buccaneers Moneyline (-500) vs New Orleans Saints

NFL Week 15 Parlay

Buffalo Bills Moneyline (-450) vs Carolina Panthers

The Buffalo Bills (7-6) are in a must-win situation in order to stay in playoff contention. Luckily, they take on a Carolina Panthers team that is really trending downward at 5-8 amid a three-game losing streak.

Quarterback Josh Allen is currently dealing with a foot sprain, which could force Mitch Trubisky into the starting lineup. Despite his struggles, Trubisky is still one of the better backups in the league. The Bills are talented enough to beat a mediocre Panthers team without their star quarterback.

Look for Buffalo’s defense to step up against this struggling offense that features an ugly committee at quarterback with Cam Newton and P.J. Walker.

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Cleveland Browns Moneyline (-175) vs Las Vegas Raiders

The Cleveland Browns got a big win over the Baltimore Ravens last week. At 7-6, this team is right in the thick of the playoff hunt with a chance at winning the AFC North. The run-heavy Browns should have success on the ground against a porous Las Vegas Raiders run defense.

The Raiders are in a tailspin right now, going 1-5 in their last six games. While wide receiver Hunter Renfrow is on an epic run, the offense is struggling as a whole, scoring fewer than 20 points in five of their last six games.

Look for the Browns to grab another win against a team that is in total disarray.

San Francisco 49ers Moneyline (-400) vs Atlanta Falcons

The San Francisco 49ers kept their playoff hopes alive with a huge road win against the Cincinnati Bengals. Deebo Samuel is back in the lineup and George Kittle is absolutely balling out. There’s also a chance that stud running back Elijah Mitchell could be back in the lineup this week.

The Atlanta Falcons are 6-7, but they have a -108 point differential, which indicates that they’re not as good as their record. This offense is mediocre without Calvin Ridley in the lineup, and Kyle Pitts is having a difficult time functioning as the clear-cut number one.

The 49ers should get the job done in this favorable matchup.

Tampa Bay Buccaneers Moneyline (-500) vs New Orleans Saints

The Tampa Bay Buccaneers are absolutely rolling since losing consecutive road games against the New Orleans Saints and Washington Football Team. Tom Brady is having an MVP-type season, leading the best offense in football.

The last time these two teams met, the Saints upset the Bucs 36-27, led by quarterback Trevor Siemian. That was just a case of a division rival getting it done at home. I really don’t expect the Saints to sweep the best team in the NFL, especially with a road win.

The Bucs are playing for the No. 1 seed, so roll with them here and make this parlay your NFL bet of the day.

Tom Brady, QB, Tampa Bay Buccaneers

Tom Brady and the Tampa Bay Buccaneers will be seeking revenge when they host the New Orleans Saints this weekend. (Image: USA TODAY Sports)

NFL Week 15 Longshot Parlay Prediction

Wager: 2 Units To Win 11.36 Units (+568) at FOX Bet

  • Indianapolis Colts Moneyline (-138) vs New England Patriots
  • Cincinnati Bengals Moneyline (+100) at Denver Broncos
  • Baltimore Ravens +4.5 Point Spread (-110) vs Green Bay Packers

NFL Week 15 Longshot Parlay

Indianapolis Colts Moneyline (-138) vs New England Patriots

The Indianapolis Colts are only 7-6, but they’re better than their record suggests. They’ve gone 6-2 in their last eight games and have a +88 point differential. We can attribute their early-season struggles to injuries, with Carson Wentz playing through pain and Quenton Nelson missing time.

This is legit contender that could make noise in the playoffs. I know that the New England Patriots are riding high right now as winners of seven straight, including a huge road win over the Buffalo Bills. However, this Colts team has the tools to snap this streak, led by an efficient offense with running back Jonathan Taylor.

I expect the Colts to get it done on the ground with Taylor here.

Cincinnati Bengals Moneyline (+100) at Denver Broncos

The Cincinnati Bengals are reeling right now as losers of two straight and four of their last six. However, this team has a great pass-rush and should cause problems for Teddy Bridgewater. The Denver Broncos’ offense has been underwhelming this season.

The Bengals have a significant advantage on offense, especially at quarterback with Joe Burrow over Bridgewater. Meanwhile, the Broncos have racked up wins against some of the worst teams in the NFL, including the Jets, Lions, Jaguars, and Giants.

The only thing Denver has going for them here is home-field advantage. The Bengals get it done here.

Baltimore Ravens +4.5 Point Spread (-110) vs Green Bay Packers

The Baltimore Ravens have really struggled on offense lately, combining for 83 points in their last five games. Lamar Jackson had to leave early last week, but signs point toward him returning to the lineup against the Green Bay Packers.

This is a tough matchup with the depleted Ravens defense going up against Aaron Rodgers, who has thrown for 10 touchdowns and zero interceptions in his last three games.

However, we’ve seen Baltimore play up to their competition under coach John Harbaugh, and I believe they’ll keep it close here.

Same Game Parlay Picks NFL Week 15

Wager: 2 Units to win 5.60 Units (+280) at FOX Bet

  • Tennessee Titans Moneyline & Total Points Over 43.5

NFL Week 15 Same Game Parlay

The Tennessee Titans bounced back with a blowout win against the hapless Jacksonville Jaguars last week. Julio Jones is back in the lineup, which should help the offense a lot. The running game has also been pretty solid with D’Onta Foreman and Dontrell Hilliard.

Meanwhile, the Pittsburgh Steelers defense is in shambles, allowing 35+ points in three of their last four games. This team is worse than their 6-6-1 record.

Look for the Titans to get it done here. I have to roll with the Over with how poorly Pittsburgh’s defense has played lately.

Frank Ammirante’s 2021 NFL Parlay Betting Record: 5-40, -11.51 Units

Thanks for reading our NFL Week 15 Parlays Picks & Predictions! For more NFL Week 15 betting tips, check out our NFL Week 15 Best Bets.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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