NFL Week 12 Parlays Picks & Predictions | NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Nov 26, 2021

Last week was another positive week for our parlay betting, so we’ll try to keep that rolling in Week 12. We’ve had some recent success focusing on underdogs, so we’ll continue to do so here.

Let’s dive in to find my favorite parlay bets for Week 12 in the NFL pick of the day series.

Please note that all odds are from Caesars Sportsbook and are current as of Tuesday, November 23, at 6 PM ET.

Best NFL Parlay Week 12

NFL Week 12 Top Parlay Picks

Wager: 2 Units To Win 14.76 Units (+738) at Caesars

  • Atlanta Falcons & Jacksonville Jaguars Under 46.5 Total Points (-110)
  • Los Angeles Rams Moneyline (-110) at Green Bay Packers
  • Denver Broncos Moneyline (+130) vs Los Angeles Chargers

Atlanta Falcons & Jacksonville Jaguars Under 46.5 Total Points (-110) at Caesars

The Atlanta Falcons have looked like an absolute mess in their last two games, being outscored 68-3. This offense has really struggled to score points, especially with Calvin Ridley (personal) out and Cordarrelle Patterson dealing with a sprained ankle.

The Jacksonville Jaguars haven’t fared much better on offense, combining for only 43 points in their last four games combined. Rookie quarterback Trevor Lawrence continues to struggle, averaging only 6.0 yards per attempt with eight touchdowns and nine interceptions, including three straight games without a passing TD.

This one has the look of an ugly, low-scoring affair between two of the worst teams in the league. The Under is 8-2 in Jaguars games, and it’s unlikely that this putrid Falcons offense will be the team to buck the trend.

Sportsbook Play Of The Day

Before making your NFL Week 12 parlay picks, you should know that Caesars Sportsbook is one of the best around. Take advantage of Caesars’ outstanding welcome bonus which matches your first bet up to $1,001 (win or lose) when you use our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our NFL Week 12 best parlays.

Los Angeles Rams Moneyline (-110) @ Green Bay Packers at Caesars

The Los Angeles Rams are coming off their bye week after suffering a disappointing blowout loss to the San Francisco 49ers. We can expect a better effort from Sean McVay‘s team here, however, especially now that they’ve had time to integrate Odell Beckham Jr. into the offense.

The Rams will look to bounce back in a tough road matchup against the Green Bay Packers. Aaron Rodgers is dealing with a toe injury, however, that may limit his ability to move around the pocket.

The line speaks volumes about the oddsmakers’ projections on this game. One would expect Green Bay to be favored by three points at home, but the game is essentially a toss-up. Give me the short odds on the healthier team coming off a bye for our NFL bet of the day.

Denver Broncos Moneyline (+130) vs Los Angeles Chargers at Caesars

The Denver Broncos are also coming off a bye and will face the Los Angeles Chargers at home in a pivotal divisional game with playoff implications. I like getting the value at plus money with the home underdog here, especially given the noted difficulty of road teams adjusting to Denver’s altitude.

Additionally, the Chargers have been inconsistent lately and always seem to find themselves in close games. They nearly blew a massive fourth-quarter lead against the Pittsburgh Steelers on Sunday Night Football, costing themselves the chance to rest their starters in the final minutes.

Los Angeles has also lost three of their last five games and has one of the worst run defenses in the league, which is bad news against the Broncos’ impressive duo of Javonte Williams and Melvin Gordon.

With Denver allowing the third-fewest points per game in the NFL this year, their defense and ability to control to clock with their run game should limit LA’s offense and give them a chance to upset the Chargers at home.

Teddy Bridgewater Denver Broncos QB

Can Teddy Bridgewater lead the Denver Broncos to a Week 12 win over the Los Angeles Chargers in their AFC West showdown? (Image: USA TODAY Sports)

NFL Week 12 Longshot Parlay Prediction

Wager: 1 Unit To Win 14.49 Units (+1449) at Caesars

  • New York Giants Moneyline (+155) vs Philadelphia Eagles
  • New York Jets Moneyline (+125) @ Houston Texans
  • Cleveland Browns Moneyline (+160) @ Baltimore Ravens

New York Giants Moneyline (+155) vs Philadelphia Eagles at Caesars

Here we have a divisional game between two teams headed in opposite directions. The New York Giants are coming off a blowout road loss to the Tampa Bay Buccaneers while the Philadelphia Eagles have won three of their last four games thanks to an increased emphasis on the run game.

The Giants’ offense looked like a mess against the Bucs, but they’re finally getting healthy and should see a boost after firing Jason Garrett. Expect the G-Men to have a better performance against a weaker defense this week.

This looks like the perfect letdown spot for the Eagles against their division rivals, and I love getting the +155 value on our NFL gameday odds in this NFC East clash. The Giants aren’t as bad as they looked on Monday Night Football, just like the Eagles aren’t as good as they’ve played during their hot streak. I’ll ride with another home dog here.

New York Jets Moneyline (+125) @ Houston Texans at Caesars

The New York Jets travel to Houston to take on a Texans team riding high from an upset win over the Tennessee Titans. While Houston is the better team with Tyrod Taylor, it’s never wise to lay juice with such a poor team.

The Jets played better with Joe Flacco under center, keeping it within a touchdown in a 7-point loss to the Miami Dolphins. It was encouraging to see their defense limit Miami to 24 points after allowing 30+ in four straight games.

While it’s always risky to bet on the Jets, especially on the road, this is a game between two 2-8 teams. Neither side has a clear advantage, so you might as well take New York at plus money.

Cleveland Browns Moneyline (+160) @ Baltimore Ravens at Caesars

The Cleveland Browns have been up-and-down lately, but despite dealing with numerous injuries they’ve still managed to win two of their past three and three of their last five, including a 41-16 blowout against the Cincinnati Bengals in Week 9.

Now, the Browns will face a Baltimore Ravens team that has a -30 point differential over its last four games. The Ravens aren’t nearly as good as their 7-3 record indicates, as they’ve only scored 17 more points than they’ve allowed this season.

While they haven’t played up to their potential this year, Cleveland has a dominant running game along with a great pass-rush led by Myles Garrett. Baltimore has played a bunch of close games this year and Lamar Jackson has been turnover-prone at times, so consider the Browns live dogs here.

Same Game Parlay Picks NFL Week 12

Tampa Bay Buccaneers @ Indianapolis Colts

Wager: 2 Units To Win 4.20 Units (+210) at Caesars

  • Tampa Bay Buccaneers Moneyline (-160)
  • Total Points Over 51.5 (-110)

NFL Week 12 TB vs IND SGP

The Tampa Bay Buccaneers are fresh off a convincing home win against the lowly New York Giants on New York Giants, while the Indianapolis Colts are coming off a huge win in Buffalo. Indianapolis has now won five of its last six games, with the only loss during that span coming in overtime against the Tennessee Titans.

The problem here is that they don’t match up well with the Bucs. The Colts’ weakness is defending the pass, which is certainly a problem against Tom Brady. Meanwhile, Jonathan Taylor may not have much room to run against Tampa Bay’s stout run defense.

I think the Buccaneers will be able to take care of business in a close, high-scoring game here, as it will be tough for Indy to slow down Brady and his passing attack. This game also has the potential to turn into a shootout between Brady and Carson Wentz, which is why I’m backing the Over here.

Frank Ammirante’s 2021 NFL Parlay Betting Record: 4-29, +0.29 Units

Thanks for reading our NFL Week 12 Parlays Picks & Predictions! For more NFL Week 12 betting tips, check out our NFL Week 12 Best Bets.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $5, Get $150in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.