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2021 NFL Early Lines Week 12 | NFL Opening Betting Odds & Implied Totals This Week

Last Updated: Nov 21, 2021

Checking NFL early lines each week gives prospective football bettors a solid idea of trends that the sportsbooks and the public will enact for that week’s action.

To offer our NFL readers perspective, we’ve gathered some Week 12 NFL Opening Lines and Odds, including moneyline, against the spread, Over/Under, and implied total points score information to start your betting off right.

2021 NFL Early Lines Week 12

All NFL Week 12 odds and lines are current as of 8:30 p.m. ET on Sunday, November 21, and provided by Caesars Sportsbook unless otherwise noted.

Chicago Bears @ Detroit Lions (12:30 p.m. ET, Thanksgiving)

  • Moneyline: Bears (-175) @ Lions (+150)
  • Spread: Bears -3.5 (-110) @ Lions +3.5 (-110)
  • Over/Under Points Total: Over 43 (-110), Under 43 (-110)
  • Implied Total Score: Bears 23.25, Lions 19.75

Bears @ Lions BET: Under 43 Total Points (-110)

Do I want a boring game to kick off the Thanksgiving slate? Absolutely not. But after Justin Fields exited the Bears’ 16-13 loss to the Ravens on Sunday with injured ribs, we could see Andy Dalton take on Jared Goff in the appetizer section of our Thanksgiving triple-header. If that’s the case, we might all be better served spending time with the family.


Sportsbook Play of the Day

Looking for a way to make NFL Early Lines bets for Week 12? You’re in luck: Claim Caesars Sportsbook’s welcome bonus that matches your first bet (win or lose) up to $1,001 using our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below. Continue reading our NFL Week 12 early lines below, and check out our best NFL odds and lines each week.


Las Vegas Raiders @ Dallas Cowboys (4:30 p.m. ET, Thanksgiving)

  • Moneyline: Raiders (+260) @ Cowboys (-330)
  • Spread: Raiders +7.5 (-110) @ Cowboys -7.5 (-110)
  • Over/Under Points Total: Over 50.5 (-110), Under 50.5 (-110)
  • Implied Score: Cowboys 29, Raiders 21.5

Buffalo Bills @ New Orleans Saints (8:20 p.m. ET, Thanksgiving)

  • Moneyline: Bills (-210) @ Saints (+175)
  • Spread: Bills -4 (-115) @ Saints +4 (-105)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Bills 25.25, Saints 21.25

Pittsburgh Steelers @ Cincinnati Bengals (1:00 p.m. ET, at BetMGM)

  • Moneyline: Steelers (+150) @ Bengals (-185)
  • Spread: Steelers +3.5 (-110) @ Bengals -3.5 (-110)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Bengals 25, Steelers 21.5

Tampa Bay Buccaneers @ Indianapolis Colts (1:00 p.m. ET)

  • Moneyline: Buccaneers (-145) @ Colts (+125)
  • Spread: Buccaneers -2.5 (-110) @ Colts +2.5 (-110)
  • Over/Under Points Total: Over 51 (-110), Under 51 (-110)
  • Implied Score: Buccaneers 26.75, Colts 24.25

Buccaneers @ Colts BET: Buccaneers -2.5 (-110)

This is a simple buy-low, sell-high spot. The Colts just demolished the Bills 41-15 in Buffalo for their third straight win and everyone is talking about Jonathan Taylor‘s five-touchdown performance. Meanwhile, Tampa Bay has lost two in a row and could be without some key performers on Monday night. I trust Tom Brady and the Buccaneers to right the ship.

Carolina Panthers @ Miami Dolphins (1:00 p.m. ET)

  • Moneyline: Panthers (-110) @ Dolphins (-110)
  • Spread: Panthers PICK (-110) @ Dolphins PICK (-110)
  • Over/Under Points Total: Over 43 (-110), Under 43 (-110)
  • Implied Score: Panthers 21.5, Dolphins 21.5

Tennessee Titans @ New England Patriots (1:00 p.m. ET)

  • Moneyline: Titans (+210) @ Patriots (-260)
  • Spread: Titans +5.5 (-110) @ Patriots -5.5 (-110)
  • Over/Under Points Total: Over 44.5 (-110), Under 44.5 (-110)
  • Implied Score: Patriots 25, Titans 19.5
Mac Jones, QB, New England Patriots

The New England Patriots are back atop the AFC East after shutting out the Atlanta Falcons on Thursday Night Football in Week 11. (Image: USA TODAY Sports)


Philadelphia Eagles @ New York Giants (1:00 p.m. ET)

  • Moneyline: Eagles (-175) @ Giants (+150)
  • Spread: Eagles -3.5 (-110) @ Giants +3.5 (-110)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Eagles 25, Giants 21.5

Atlanta Falcons @ Jacksonville Jaguars (1:00 p.m. ET)

  • Moneyline: Falcons (-110) @ Jaguars (-110)
  • Spread: Falcons PICK (-110) @ Jaguars PICK (-110)
  • Over/Under Points Total: Over 48 (-110), Under 48 (-110)
  • Implied Score: Falcons 24, Jaguars 24

New York Jets @ Houston Texans (1:00 p.m. ET)

  • Moneyline: Jets (+140) @ Texans (-160)
  • Spread: Jets +3 (-110) @ Texans -3 (-110)
  • Over/Under Points Total: Over 44 (-110), Under 44 (-110)
  • Implied Score: Texans 23.5, Jets 20.5

Los Angeles Chargers @ Denver Broncos (4:05 p.m. ET, at BetMGM)

  • Moneyline: Chargers (-125) @ Broncos (+105)
  • Spread: Chargers -1.5 (-110) @ Broncos +1.5 (-110)
  • Over/Under Points Total: Over 49 (-110), Under 49 (-110)
  • Implied Score: Chargers 25.25, Broncos 23.75

Los Angles Rams @ Green Bay Packers (4:25 p.m. ET)

  • Moneyline: Rams (+110) @ Packers (-130)
  • Spread: Rams +2 (-110) @ Packers -2 (-110)
  • Over/Under Points Total: Over 50 (-110), Under 50 (-110)
  • Implied Score: Packers 26, Rams 24

Rams @ Packers BET: Rams +2 (-110)

The bye week arrived at the right time for the Rams, who have lost back-to-back games in large part because of poor play from quarterback Matthew Stafford. I’d expect Sean McVay spent the week working on ways to incorporate Odell Beckham Jr. into the offense and build Stafford’s confidence back up. Green Bay’s defense is exposable and Aaron Rodgers is dealing with a foot injury. Give me the Rams as our NFL pick of the day.

Minnesota Vikings @ San Francisco 49ers (4:25 p.m. ET)

  • Moneyline: Vikings (+120) @ 49ers (-140)
  • Spread: Vikings +2.5 (-110) @ 49ers -2.5 (-110)
  • Over/Under Points Total: Over 48.5 (-110), Under 48.5 (-110)
  • Implied Score: 49ers 25.5, Vikings 23

Cleveland Browns @ Baltimore Ravens (Sunday Night Football, 8:20 p.m. ET)

  • Moneyline: Browns (+180) @ Ravens (-220)
  • Spread: Browns +4.5 (-110) @ Ravens -4.5 (-110)
  • Over/Under Points Total: Over 46.5 (-110), Under 46.5 (-110)
  • Implied Score: Ravens 25.5, Browns 21

Seattle Seahawks @ Washington Football Team (Monday Night Football, 8:15 p.m. ET)

  • Moneyline: Seahawks (-160) @ Washington (+140)
  • Spread: Seahawks -2.5 (-105) @ Washington +2.5 (-115)
  • Over/Under Points Total: Over 46 (-110), Under 46 (-110)
  • Implied Score: Seahawks 24.25, Washington 21.75

Author

John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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