Monday Night Football Predictions Week 13 | MNF Picks & Patriots vs Bills Best Bets

Last Updated: Dec 6, 2021

The best game in Week 13 will come on Monday Night Football as the 8-4 New England Patriots take on the 7-4 Buffalo Bills with first place in the AFC East on the line. The winner will be in prime position to not only win the division but also potentially have a first-round bye in the playoffs.

Needless to say, this is a huge game for both sides. So who should you bet on in this AFC East battle? Let’s dive into the odds and give our best MNF betting picks.

Please note that all NFL Week 13 MNF odds and lines are current as of 3 PM EST on Monday, December 6.

Monday Night Football Prediction Week 13

Since losing to the Dallas Cowboys in overtime in Week 6, the Patriots have been on a roll. They’ve won six straight games and have allowed just 63 total points during that stretch. Rookie quarterback Mac Jones has come into his own, but what’s really driving New England’s success is their elite defense and rushing attack.

Sportsbook Play of the Day

Before making your best MNF betting picks, you should know that TwinSpires Sportsbook is one of the best around. Take advantage of TwinSpires’ outstanding welcome bonus which gives you a with no promo code required.

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Meanwhile, the Bills have been uneven since their hot start, alternating wins and losses over their last six games. It’s been a frustrating stretch for one of the NFL’s most talented teams, who suddenly find themselves looking up at the Patriots in their own division.

That said, Buffalo is coming off a huge win over the New Orleans Saints on Thanksgiving and will have 11 days to prepare for this critical matchup. They’ll also have the benefit of home-field advantage, where their crowd will bring the noise during primetime.

In a battle between the NFL’s two best defenses, expect a low-scoring game where Josh Allen and the Bills’ superior offensive talent wins out.

NFL Week 13 MNF Prediction: Bills 20, Patriots 17

Jordan Poyer Buffalo Bills Defense

Can the Buffalo Bills beat the AFC East-leading New England Patriots on Monday Night Football in NFL Week 13? (Image: USA TODAY Sports)

Monday Night Football Best Bets Week 13

MNF Best Bet: Patriots +2.5 (-106) on TwinSpires

Wager: 1 Unit

According to our NFL gameday odds, this game is likely going to be decided by a field goal. These two teams are very similar and it’s a coin flip as to who will actually win.

It’s also worth noting that New England has won eight of their last nine games in Buffalo, so it wouldn’t be a total shock if they won outright. We know how good their defense is and a Bill Belichick team is never afraid of playing on the road in a divisional matchup.

Take the Pats against the spread in what should be a tight game in Buffalo on Monday night.

MNF Best Bet: Under 41 Total Points (-109) on TwinSpires

Wager: 1 Unit

These two teams have been the best defenses in the NFL this season, with New England allowing just 15.8 points per game and Buffalo yielding only 16.5. Both teams are coming off outstanding defensive performances and the Patriots have been especially stingy of late, permitting just 26 points over their last four games combined.

Weather could also limit offense in this matchup, as it’s expected to be a cold and windy night in Buffalo. That will make passing and kicking even more difficult.

This has all the makings of a 20-17 slugfest as both teams lean on their defense to win. Take the Under for our NFL bet of the day.


Marcus Mosher

Marcus Mosher is an NFL analyst at The Game Day, residing in Erie, PA. He covers the NFL from a betting and fantasy perspective, producing written and video content. Marcus currently hosts multiple football-related podcasts and is a managing editor at USA Today’s Sports Media Group covering the Las Vegas Raiders. He has previously worked at The Athletic and Bleacher Report.

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