Cardinals vs Colts Week 16 Prop Bets | Kyler Murray, Jonathan Taylor, & More

Last Updated: Dec 25, 2021

Fresh off a huge win against the conference-leading Patriots, the Indianapolis Colts (8-6) will head to Phoenix on Christmas Day to take on the Arizona Cardinals (10-4).

Both teams still have a lot to play for. The Colts are still in the hunt for the AFC South, while the Cardinals are fighting for home field advantage in the NFC.

Last week, Jonathan Taylor dominated in the run game en route to a win over the Patriots, while Carson Wentz and the Colts passing offense struggled mightily.

Kyler Murray and the Cardinals, on the other hand, are coming off a rough showing overall in their surprising loss to the Detroit Lions. They’ll look to rebound this week as they continue to figure out how to deal without DeAndre Hopkins.

Let’s dig in to find the best Cardinals vs Colts prop bets for this weekend’s inter-conference battle.

Please note that all NFL gameday odds and lines are current as of 12:00 p.m. ET on Thursday, December 23.

Cardinals vs Colts Prop Bets: NFL Week 16 Prop Betting Picks

Carson Wentz: Under 209.5 Total Passing Yards (-115) at Caesars

Wager: 1 Unit

Carson Wentz has really struggled in his last two games, combining for just 215 total passing yards. Now, two games doesn’t make a trend, but it’s the beginning of one.

I also don’t like his matchup against a Cardinals defense that is fifth-best in the league in terms of allowing passing yards to opposing quarterbacks at 224.7 yards per game.

The Colts offense is essentially the Jonathan Taylorshow at this point too, so it’s going to be hard for Wentz to even have enough opportunities to overcome the already-challenging hurdles of his recent play and his opponent.

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Kyler Murray: Over 0.5 Total Interceptions (-150) at Caesars

Wager: 0.5 Unit

Kyler Murray is still great, but like Carson Wentz, he’s struggled a bit recently. He’s thrown three interceptions in his last three games since returning from injury, and he’s now thrown six interceptions in his last five games.

On the other side of the ball, the Colts lead the league in takeaways. They live on that stuff. They’re currently averaging 1.2 interceptions per game on the season and will be circling like sharks whenever Murray drops back to pass without Hopkins to look for.

Jonathan Taylor: Over 106.5 Total Rushing Yards (-115) at Caesars

Wager: 1 Unit

I don’t generally like going over when we’re talking 100-plus yards, but I’m willing to make an exception for 2021 Jonthan Taylor. He’s gone over 100 yards five times in his last six games and has seen a big increase in rushing attempts during that span.

The Colts will again lean on Taylor this week, especially since the Cardinals are a middling team in terms of limiting opposing rushing attacks and allow an average of 93.9 yards per game. That’s not 100, but Arizona has allowed multiple 100-plus yard games in order to get to that average.

Bank on Taylor to hit this prop and make this your NFL bet of the day.

Michael Pittman: Under 57.5 Total Receiving Yards (-115) at Caesars

Wager: 0.5 Unit

Michael Pittman is Indy’s best receiver, but that doesn’t mean a whole lot these days. Pittman has only topped 55 yards once in his last four games and has only seen an average of 6.5 targets per game over that span.

The Cardinals are also one of the better teams in the league in terms of limiting yardage allowed to opposing receivers. Pittman will be Arizona’s main focus in the passing game, and they should be able to limit the damage he does.

Thanks for reading our NFL Week 16 Cardinals vs Colts Prop Bets! For more NFL Week 16 betting tips and tipster picks, check out our NFL Week 16 Best Bets and NFL Week 16 Prop Bets.


Nick Roberts

Nick is an analyst at The Game Day who writes about the NFL and NBA from a betting perspective. He previously contributed to RotoWorld, Rotowire, and The New York Times. Nick resides in New Jersey.

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