Best MLB Bet Today: MLB Betting Pick Of The Day 9/22/21

Last Updated: Sep 22, 2021

Here is our best MLB Betting Pick Of The Day, including the Best Baseball Pick Today, 9/22/21. All odds for September 22 MLB bet picks were obtained from DraftKings.

Our hot streak finally came to an end last week, but the great thing about sports betting is that there’s always another game. With less than two weeks remaining in the MLB regular season, let’s try to get back on track with one of my best MLB bets today.

Best MLB Betting Pick Today

For in-depth analysis of this MLB bet of the day, continue reading.

Season Betting Record

  • Overall: 37-23 (+8.66 units)
  • Team Totals: 12-7 (+2.62 units)
  • First 5 IP Bets: 20-10-3 (+7.89 units)
  • Moneylines: 3-3 (-0.5 units)
  • Totals: 1-2 (-1.35 units)

Sportsbook Play of the Day

Before making your next MLB bet, you should know that DraftKings Sportsbook is one of the best around, offering tons of promotions and great welcome offers. Take advantage of DraftKings’ welcome bonus, which gives you a first deposit bonus of up to $1,000 with .

Read Anthony Cervino’s DraftKings Sportsbook review for more insight and get your welcome bonus below, or continue reading our MLB pick of the day.

MLB Bet Of The Day 9/22/21

Atlanta Braves @ Arizona Diamondbacks (9:40 p.m. ET)

  • Probable Pitchers: ATL RHP Ian Anderson @ ARI RHP Merrill Kelly

This is one of the more lopsided matchups on today’s slate with the first-place Atlanta Braves taking on the Arizona Diamondbacks, who have the worst record in the National League. As expected, Atlanta has dominated the series thus far, winning the first two games by a combined score of 17-5.

The Braves will shoot for their fourth straight win tonight against Merrill Kelly, who’s 7-10 with a 4.41 ERA this season. He’s been rocked over his last two starts, however, allowing nine runs on 21 hits in just 9 2/3 innings, surrendering three homers as well.

Atlanta has had a strong offense all year and has been one of MLB’s best-hitting teams in September, ranking ninth in wOBA (.327) and second in ISO (.223) this month. The Braves also lead all NL teams with 33 homers this month, averaging 1.8 per game.

With favorable splits against right-handers this year (.761 OPS vs. RHP / .732 OPS vs. LHP), Atlanta will make Kelly pay if he continues to leave balls over the plate, especially at the hitting-friendly Chase Field. The Braves are still fighting to secure the NL East flag while the Diamondbacks haven’t played a meaningful game in months, so look for Atlanta to come out swinging against Kelly.

Baseball Bet Of The Day: Braves Over 2.5 Runs In 1st 5 Innings (-115)

Wager: 1.15 Units

Thanks for reading our MLB Bet of the Day! For more MLB betting tips, check out our Best MLB Player Prop Bets Today.


Jason Radowitz

Jason Radowitz is a jack of all trades when it comes to writing sports. Jason writes and bets the MLB, NFL, NBA, NCAAF, and NCAAB when the sports are in season. Currently, he's a Writer and Betting Analyst for The Game Day providing daily content in the MLB. Earlier in his sports career, Jason was a graduate assistant for the University of Hartford Men's Basketball team using analytics and numbers to help put together the winningest season in program history. With his articles, you will be sure to get an analytical approach.

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