USC vs Oregon Predictions

Last Updated: Nov 6, 2023

USC’s College Football Playoff hopes might be over, but when two of the top 10 offenses in the country face off, it’s must-watch television.

That’s what we’ll be in for when the USC Trojans head north to face the No. 6 Oregon Ducks on Saturday night.

Read on for our free USC Trojans vs Oregon Ducks college football picks and predictions for Saturday, Nov. 11, at 10:30 p.m. ET.

USC vs Oregon Odds

Track our latest CFB odds for Trojans vs Ducks:

NCAAF lines used for USC vs Oregon were current as of Monday, Nov. 6, at midnight ET on DraftKings Sportsbook.

  • Moneyline: Oregon (-850) • USC (+575)
  • Spread: Oregon -14.5 (-110) • USC +14.5 (-110)
  • Total Points: Over 73.5 (-110) • Under 73.5 (-110)

Oregon is installed as a 14.5-point favorite with an interesting half-point hook, while the Over is set at a high but not surprising 73.5 as two of the country’s best offenses square off.

USC vs Oregon Prediction

SCORE PICK: Oregon 55, USC 38

These two teams are moving to the Big Ten together next year, but this game will be the last true edition of Pac-12 After Dark played between these iconic West Coast powers.

Oregon, with just one tight loss to fellow contenders Washington, is bringing high aspirations into this meeting, and USC will be looking to play the spoiler.

After a crushing loss to Washington, USC’s conference hopes are dashed. Last year’s Heisman winner, quarterback Caleb Williams, was in tears after the loss, which likely spells an end to any hopes he had of winning a title in his USC career, as he is widely expected to be the first overall pick in the upcoming NFL draft.

Things only appear to be getting worse for the Trojans, as they take on the other top contender in the Pac-12, but this time they have to go on the road to legendary Autzen Stadium instead of playing host. The Ducks are coming off of a 63-19 dismantling of Cal.

Quarterback Bo Nix threw all over the Golden Bears, and he continues to hang around the Heisman race.

Any signs of life shown by the USC defense are a mere glimmer of the past, as the unit has been run all over by offenses elite and mediocre alike.

Defensive coordinator Alex Grinch was finally fired, but it’s probably too little, too late as Oregon’s high-powered attack is still going to absolutely rip through the Trojans’ defense.

USC vs Oregon Best Bets

Oregon -14.5 (-110)

DraftKings Sportsbook • WAGER: 1 Unit

Oregon is one of the best teams in the country, ranking second overall in EPA per play, and it would be ranked even higher in the polls if it ended up on the other side in a close game at Washington. This is a well-rounded unit; it’s top 20 in defensive EPA despite playing in the hyper-offensive Pac-12.

It is going up against a USC team that has completely bottomed out, as it’s avoided a four-game losing streak by just a point in a 50-49 win against Cal. The Trojans are unranked in the AP Poll for the first time under head coach Lincoln Riley and won’t be able to be at their best offensively on the road in Autzen.

Over 73.5 (-110)

DraftKings Sportsbook • WAGER: 1 Unit

As great as Oregon’s defense has been, the offense under Nix is even better, ranking second in the country in EPA per play. Bucky Irving is one of the best running backs in the conference, Troy Franklin has already cracked the 10-touchdown plateau and is just a few catches away from 1,000 receiving yards, and the offensive line has been one of the nation’s best.

USC’s offense with Williams at the helm has hardly slipped - it hung 45 points on Washington, 50 on Cal, and 32 on a well-respected Utah defense in its three games. Its defense is a problem, ranking 99th in EPA per play, but that’s all the better for our purposes in this game between fast-paced offenses.

USC vs Oregon Same Game Parlay

USC vs Oregon SGP (+155)

DraftKings Sportsbook • WAGER: 0.50 Units

  • Over 73.5 (-110)
  • Oregon (-850)

As heavily favored as the Ducks are, this is basically just a slight odds boost on the Over. We don’t have too many options to parlay this early in the week, but there could be value in choosing an alternate spread such as -13.5 or even -9.5 in place of the moneyline to pair with the Over.


William Schwartz

As a former athlete and lifetime fan, sports have always been a huge part of my life. I've written about them for almost as long as I've been watching and playing them, from a blog I wrote with a friend in middle school, to journalism classes at the University of Michigan, to today. I hope to bring you entertaining coverage, strong analysis, and profitable betting picks on any and all sports, whether it's MLB baseball, college football, European soccer, or anything in between.

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