Notre Dame vs Ohio State Predictions & Bets

Last Updated: Sep 19, 2023

The No. 6 Ohio State Buckeyes head to South Bend next week for a prime-time matchup against the Notre Dame Fighting Irish.

It’s the crown jewel of an exciting Week 4 slate. Who doesn’t love a showdown between two of the most storied teams in college football?

Ohio State vs Notre Dame Odds

Track our latest CFB odds for the Buckeyes vs the Irish.

NCAAF lines used below for Ohio State @ Notre Dame were current as of Sept. 15 at 10:30 a.m. EST on Caesars Sportsbook.

  • Moneyline: Ohio State (-155) • Notre Dame (+130)
  • Spread: Ohio State -3 (-110) • Notre Dame +3 (-110)
  • Total Points: Over 54 (-110) • Under 54 (-110)

While some expected Ohio State to be the heavier favorite, the market clearly has a lot of respect for Notre Dame’s improved quarterback play.

Ohio State vs Notre Dame Prediction

SCORE PICK: Ohio State 30, Notre Dame 27

Notre Dame has been moving in the right direction, and it finally has a quarterback who can generate explosive plays.

Last season becomes a lot more impressive when you realize how many games the Irish won with Tyler Buchner and Drew Pyne, who both looked awful and were benched at their respective new schools.

Sam Hartman was a strong quarterback at Wake Forest and has looked good in a new system thus far.

He’s provided ample reasons to have faith that he will step up in the big moments. Pair him with stud running back Audric Estime, who’s posted 8.3 YPC on 63 carries this season, and you’ve got something cooking!

This offense finally has weapons to contend with the big guns. Additionally, Notre Dame has started the season 3-0-1 ATS, while Ohio State currently sits at 1-2-0 (and 3-6-0 L9).

The Buckeyes have a dominant array of NFL weapons at their disposal. But the question is: Can Kyle McCord step up in his biggest test yet?

This is a well-rounded team that has shown out on defense, but its strongest opponent so far has been the unimpressive Indiana.

This Notre Dame team will put up a solid performance, but the visitors will close it out.

(Find the top Ohio sportsbooks where you can wager on the Buckeyes.)

Ohio State vs Notre Dame Best Bets

Over 54 (-110)

DraftKings Sportsbook • WAGER: 1 unit

This CFB best bet accounts for plenty of scoring, notably thanks to the home team’s new potent offense.

That was with pretty underwhelming quarterback play and an offensive scheme that looked to hide its quarterback rather than highlight him. Now, with a suitable replacement whose Heisman odds have soared, the Irish are starting to have a little fun on offense.

I’m expecting a measured improvement from what we’ve seen in the past, and Notre Dame already cleared its first challenge, scoring 45 in a rainy matchup against a strong NC State squad.

If you’re in South Bend, there is one player you absolutely can’t let beat you. Over the last two games, star receiver Marvin Harrison Jr. has had 12 receptions for 286 yards and three touchdowns.

Harrison, who is almost a lock to go in the top 10 of next year’s NFL draft, will likely see frequent double teams and plenty of safety attention.

The problem is that TreVeyon Henderson and Emeka Egbuka are also extremely valuable weapons who will take advantage of the better matchups.

Ohio State has built up an incredibly strong offensive line, but it will face its toughest test yet. The trenches will decide this game, and the Buckeyes will give McCord time to get his skill position players involved.

(Notre Dame fans: Fight for the best game odds at the top Indiana sportsbooks.)

Ohio State (-3) -110

DraftKings Sportsbook • WAGER: 0.5 unit

This will be a close matchup, but I have to back the more well-rounded team. Ohio State showcased everything that explosive offense can do last week, and I just don’t see how you can successfully game plan against a team with so many high-end weapons.

Both Buckeye wide receivers should put up incredibly impressive stat lines, and I’m worried Estime may struggle on the other side.

Ohio State has been dominant against the rush this season, which will be a major point in this game. Notre Dame rarely plays teams with this much power on the inside, and I expected it will be punished.

What happens when Notre Dame can’t successfully establish the run? What happens when Hartman faces more pressure than he has all season?

There are a lot of questions on both sides, but Ohio State is the stronger overall team and on the right side of this matchup.

Ohio State vs Notre Dame Same Game Parlay

OSU-ND same-game parlays are not yet available.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

$1,500 No Sweat Bet + NBA SGP Token

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $150 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.