Louisville vs Florida State Predictions

Last Updated: Nov 27, 2023

The No. 4 Florida State Seminoles face the No. 15 Louisville Cardinals for the ACC title in Charlotte, North Carolina, on Saturday at 8 p.m. ET.

Louisville is out of the College Football Playoff but can still win its first-ever ACC title, while FSU is 12-0 and pushing for a second CFP berth — although without former Heisman contender Jordan Travis.

Louisville vs Florida State Odds

Track our latest CFB odds for Cardinals vs Seminoles:

NCAAF lines used for Louisville vs Florida State were current as of Nov. 26 at 11:30 p.m. ET on DraftKings Sportsbook.

  • Moneyline: Florida State (-180) • Louisville (+150)
  • Spread: Florida State -3.5 (-108) • Louisville +3.5 (-112)
  • Total Points: Over 51 (-110) • Under 51 (-110)

Even without star quarterback Travis following a season-ending leg injury, Florida State is favored by more than a field goal in this one in part because of Louisville’s loss to Kentucky in its last game.

Louisville vs Florida State Prediction

SCORE PICK: Louisville 26, Florida State 17

It’s hard to understand how Florida State is still the pick after losing Travis for the year.

Even if we take a look at season-long numbers, including Travis’ tenure, the Seminoles are a strong eighth in the country in EPA per play, but the Cardinals – who have not suffered any devastating injuries since building the vast majority of their resume – are right behind at 12th.

Perhaps most importantly, this FSU offense, even with Travis, hasn’t seen many defenses as strong as Louisville’s, which ranks seventh in the country by EPA.

In the Seminoles’ first game with starting quarterback Tate Rodemaker against a Florida team that ranks much closer to average in defensive metrics, they scraped out 24 points thanks in large part to a late flurry.

FSU’s defensive metrics are also a bit inflated from a lack of solid competition. Even so, its run defense doesn’t stack up well with the Louisville ground offense, led by running back Jawhar Jordan.

Not only will Louisville pull off the upset, it will do it in style as Florida State fails to hang around without its star QB.

Louisville vs Florida State Best Bets

Louisville (+150)

DraftKings Sportsbook • WAGER: 1 unit

There’s no way around it: Louisville got caught in a trap game. The Cardinals have never played in an ACC Championship Game before, and they let their minds wander instead of focusing on the task at hand and dropped their regular-season finale against Kentucky.

This is a great spot to buy low on the Cardinals, as that performance was an outlier.

It’s hard to imagine this FSU defense stopping Jordan and the Cardinals’ run game. Its ground defense is ranked just 74th in the country and will also have to contend with second back Isaac Guerendo, who is averaging 6.1 yards per carry and has scored eight times.

Under 51 (-110)

DraftKings Sportsbook • WAGER: 1 unit

This number is placed a bit more appropriately than the spread, but there’s still value on the table, as the Under gives us access to several key numbers – such as 45 and 48, as well as a push on 51 itself.

Louisville is one of the most run-heavy teams in the country, ranking 38th in run play percentage, which contributes to its place at 103rd in pace of play by seconds per snap.

On the other side of the ball, FSU is generally a pass-first team, but it is still only 82nd in pace.

With Travis out, FSU is not likely to start throwing the ball more, especially against an elite Louisville defense. But it’s also hard to envision it finding success if it is transparently run-heavy, as the Cardinals are a remarkable fifth in the country in EPA per play against the run.

Louisville vs Florida State Same-Game Parlay

Louisville vs Florida State SGP (+270)

DraftKings Sportsbook • WAGER: 0.5 units

  • Louisville +3.5 (-112)
  • Under 51 (-110)

We don’t have a ton of same-game parlay options nearly a week ahead of game day, but we have some really good ones nonetheless.

The spread of 3.5 is great protection for the Louisville portion of our wager, as it includes a half-point hook that allows us to win if the Cardinals lose by exactly a field goal. Elsewhere, we will stick with our Under at the excellent number of 51.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Bet $5, Get $150in Bonus Bets

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $200 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.