Entering Matchweek 21, Manchester City, Manchester United, and Newcastle sit just one point within each other in the top four, while Arsenal sits eight points clear at the top.
The battle for the top six is even tighter, with clubs such as Tottenham, Fulham, Brighton, Brentford, Liverpool, and Chelsea all within five points.
This week several of those teams are featured in our betting picks against clubs in the bottom half of the EPL.
What are the best bets for Matchweek 21 in the Premier League? Read on for my picks and predictions below.
Leicester City vs Brighton Best Bet
Tie or Brighton Win & Over 2.5 Goals (+145) at BetMGM Sportsbook
WAGER: 1 Unit
Brighton have secured three points in three of their last four league matches, and five of their previous seven.
In addition, each of the Seagulls’ previous eight matches have ended with more than 2.5 goals (six have produced more than 3.5 goals).
I expect that trend to continue against Leicester City, who has conceded the third-most goals in the Premier League this season (33).
Look for Brighton to earn a result in a high-scoring showdown on the road in our EPL pick of the day.
Crystal Palace vs Newcastle Best Bet
Newcastle Win to Nil (+190) at BetMGM Sportsbook
WAGER: 1 Unit
Newcastle leads the Premier League in clean sheets this season, having conceded a league-best 11 goals in 19 matches. The Magpies have earned 11 shutouts on their way to a 10-8-1 record.
Meanwhile, Palace has managed to outscore just four other clubs in the EPL. The Eagles have failed to reach the back of the net in four of their five previous games.
- Interested in the latest Premier League odds? Head over to our EPL Winner Odds & Predictions page.
Look for Nick Pope to shut down Crystal Palace.
Leeds United vs Brentford Best Bet
Tie or Brentford Win & Over 2.5 Goals (+200) at BetMGM Sportsbook
WAGER: 1 Unit
Leeds United have seen 12 of their 18 Premier League matches produce at least three goals this season, with Over 2.5 goals hitting in seven of their previous eight games.
On the other side, the Bees have seen 11 of their 19 matches produce more than 2.5 goals.
I expect Ivan Toney to find the back of the net against a Leeds side that has conceded 33 goals.
Premier League Matchweek 21 Fixtures
- Liverpool vs Chelsea (Sat, Jan. 21)
- Leicester City vs Brighton (Sat, Jan. 21)
- Southampton vs Aston Villa (Sat, Jan. 21)
- West Ham vs Everton (Sat, Jan. 21)
- Bournemouth vs Nottingham Forest (Sat, Jan. 21)
- Crystal Palace vs Newcastle (Sat, Jan. 21)
- Manchester City vs Wolverhampton (Sun, Jan. 22)
- Leeds United vs Brentford (Sun, Jan. 22)
- Arsenal vs Manchester United (Sun, Jan. 22)
- Fulham vs Tottenham (Mon, Jan. 23)