NFL Week 15 Parlays Picks & Predictions | NFL Play of the Day

It was a tough week in parlay betting. We were really close to a winning week, just missing out on our (+596) parlay because the Washington Football Team could not get it done. Time to keep it simple this week.

Let’s dive in to find my favorite parlay bets for Week 15 in the NFL pick of the day series.

Please note that all NFL gameday odds are from FOX Bet Sportsbook and are current as of 5:00 p.m. ET on Tuesday, December 14. 

Best NFL Parlay Week 15

NFL Week 15 Top Parlay Picks

Wager: 5 Units To Win 9.40 Units (+188) at FOX Bet

  • Buffalo Bills Moneyline (-450) vs Carolina Panthers
  • Cleveland Browns Moneyline (-175) vs Las Vegas Raiders
  • San Francisco 49ers Moneyline (-400) vs Atlanta Falcons 
  • Tampa Bay Buccaneers Moneyline (-500) vs New Orleans Saints

NFL Week 15 Parlay

Buffalo Bills Moneyline (-450) vs Carolina Panthers

The Buffalo Bills (7-6) are in a must-win situation in order to stay in playoff contention. Luckily, they take on a Carolina Panthers team that is really trending downward at 5-8 amid a three-game losing streak.

Quarterback Josh Allen is currently dealing with a foot sprain, which could force Mitch Trubisky into the starting lineup. Despite his struggles, Trubisky is still one of the better backups in the league. The Bills are talented enough to beat a mediocre Panthers team without their star quarterback.

Look for Buffalo’s defense to step up against this struggling offense that features an ugly committee at quarterback with Cam Newton and P.J. Walker.


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Cleveland Browns Moneyline (-175) vs Las Vegas Raiders

The Cleveland Browns got a big win over the Baltimore Ravens last week. At 7-6, this team is right in the thick of the playoff hunt with a chance at winning the AFC North. The run-heavy Browns should have success on the ground against a porous Las Vegas Raiders run defense.

The Raiders are in a tailspin right now, going 1-5 in their last six games. While wide receiver Hunter Renfrow is on an epic run, the offense is struggling as a whole, scoring fewer than 20 points in five of their last six games.

Look for the Browns to grab another win against a team that is in total disarray.

San Francisco 49ers Moneyline (-400) vs Atlanta Falcons

The San Francisco 49ers kept their playoff hopes alive with a huge road win against the Cincinnati Bengals. Deebo Samuel is back in the lineup and George Kittle is absolutely balling out. There’s also a chance that stud running back Elijah Mitchell could be back in the lineup this week.

The Atlanta Falcons are 6-7, but they have a -108 point differential, which indicates that they’re not as good as their record. This offense is mediocre without Calvin Ridley in the lineup, and Kyle Pitts is having a difficult time functioning as the clear-cut number one.

The 49ers should get the job done in this favorable matchup.

Tampa Bay Buccaneers Moneyline (-500) vs New Orleans Saints

The Tampa Bay Buccaneers are absolutely rolling since losing consecutive road games against the New Orleans Saints and Washington Football Team. Tom Brady is having an MVP-type season, leading the best offense in football.

The last time these two teams met, the Saints upset the Bucs 36-27, led by quarterback Trevor Siemian. That was just a case of a division rival getting it done at home. I really don’t expect the Saints to sweep the best team in the NFL, especially with a road win.

The Bucs are playing for the No. 1 seed, so roll with them here and make this parlay your NFL bet of the day.

prop bet

+188

Bills, Browns, Buccaneers, & 49ers All To Win (NFL Week 15)

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Tom Brady, QB, Tampa Bay Buccaneers

Tom Brady and the Tampa Bay Buccaneers will be seeking revenge when they host the New Orleans Saints this weekend. (Image: USA TODAY Sports)


NFL Week 15 Longshot Parlay Prediction

Wager: 2 Units To Win 11.36 Units (+568) at FOX Bet

  • Indianapolis Colts Moneyline (-138) vs New England Patriots
  • Cincinnati Bengals Moneyline (+100) at Denver Broncos
  • Baltimore Ravens +4.5 Point Spread (-110) vs Green Bay Packers

NFL Week 15 Longshot Parlay

Indianapolis Colts Moneyline (-138) vs New England Patriots

The Indianapolis Colts are only 7-6, but they’re better than their record suggests. They’ve gone 6-2 in their last eight games and have a +88 point differential. We can attribute their early-season struggles to injuries, with Carson Wentz playing through pain and Quenton Nelson missing time.

This is legit contender that could make noise in the playoffs. I know that the New England Patriots are riding high right now as winners of seven straight, including a huge road win over the Buffalo Bills. However, this Colts team has the tools to snap this streak, led by an efficient offense with running back Jonathan Taylor.

I expect the Colts to get it done on the ground with Taylor here.

Cincinnati Bengals Moneyline (+100) at Denver Broncos

The Cincinnati Bengals are reeling right now as losers of two straight and four of their last six. However, this team has a great pass-rush and should cause problems for Teddy Bridgewater. The Denver Broncos’ offense has been underwhelming this season.

The Bengals have a significant advantage on offense, especially at quarterback with Joe Burrow over Bridgewater. Meanwhile, the Broncos have racked up wins against some of the worst teams in the NFL, including the Jets, Lions, Jaguars, and Giants.

The only thing Denver has going for them here is home-field advantage. The Bengals get it done here.

Baltimore Ravens +4.5 Point Spread (-110) vs Green Bay Packers

The Baltimore Ravens have really struggled on offense lately, combining for 83 points in their last five games. Lamar Jackson had to leave early last week, but signs point toward him returning to the lineup against the Green Bay Packers.

This is a tough matchup with the depleted Ravens defense going up against Aaron Rodgers, who has thrown for 10 touchdowns and zero interceptions in his last three games.

However, we’ve seen Baltimore play up to their competition under coach John Harbaugh, and I believe they’ll keep it close here.

prop bet

+568

Colts To Win, Bengals To Win, & Ravens To Cover +4.5 Spread (NFL Week 15)

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Bet $20, Payout $134


Same Game Parlay Picks NFL Week 15

Wager: 2 Units to win 5.60 Units (+280) at FOX Bet

  • Tennessee Titans Moneyline & Total Points Over 43.5

NFL Week 15 Same Game Parlay

The Tennessee Titans bounced back with a blowout win against the hapless Jacksonville Jaguars last week. Julio Jones is back in the lineup, which should help the offense a lot. The running game has also been pretty solid with D’Onta Foreman and Dontrell Hilliard.

Meanwhile, the Pittsburgh Steelers defense is in shambles, allowing 35+ points in three of their last four games. This team is worse than their 6-6-1 record.

Look for the Titans to get it done here. I have to roll with the Over with how poorly Pittsburgh’s defense has played lately.

prop bet

+280

Tennessee Titans To Win & Total Points Over 43.5 @ Steelers (NFL Week 15)

TEN @ PIT | 12/19, 1:00 PM ET

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Bet $20, Payout $76

Frank Ammirante’s 2021 NFL Parlay Betting Record: 5-40, -11.51 Units

Thanks for reading our NFL Week 15 Parlays Picks & Predictions! For more NFL Week 15 betting tips, check out our NFL Week 15 Best Bets.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page