Thursday Night Football Predictions Week 15 | TNF Picks & Chiefs vs Chargers Best Bets

The Kansas City Chiefs will visit the Los Angeles Chargers at SoFi Stadium in the NFL Week 15 edition of Thursday Night Football at 8:20 p.m ET on the NFL Network with first place in the AFC West on the line.

Both teams remain within a game of each other in the standings after enjoying blowout wins in Week 14. The 9-4 Chiefs will look to stay on top of the AFC West with a seventh straight victory, while the 8-4 Chargers will look to reclaim first place after allowing Kansas City to pass them.

Who will prevail in primetime between these two high-powered offenses? Let’s dig in with our NFL Week 15 TNF predictions and best bets.

Thursday Night Football Prediction Week 15

After facing off in Week 3, Kansas City and Los Angeles will meet again in Week 15 in a game with postseason vibes.

While the Chiefs lost their previous matchup in a 30-24 shootout at Arrowhead, their defense has improved dramatically since then. They’ve allowed just nine points in three consecutive games and an average of 10.8 points per game over their previous six.

Kansas City’s offense has cooled off from its strong start, however. While the Chiefs are coming off a 48-point explosion against the Last Vegas Raiders, they’ve struggled against other teams and have been held to 22 points or less in five of their last seven games.


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Patrick Mahomes and co. will need to step up if they want to keep pace with LA’s surging offense, however, which has scored at least 37 points in three of its last four games. The Chiefs must play a complete game in order to win, as they can’t expect their defense to contain Justin Herbert and the Chargers for a full 60 minutes.

Los Angeles has been up and down this year, so the key for them is playing consistent football. They’ve started to heat up again with three wins in their last four games, so it will be imperative to carry that momentum into Thursday night’s game.

The Chargers have also struggled on defense for much of the season, surrendering an average of 29.1 points per game over their last nine games. While Kansas City’s offense hasn’t been as explosive this year, look for Mahomes to pick apart one of the worst units in the NFL.

When it’s all said and done, I’ll put my trust in the hands of Andy Reid and Mahomes. In close matchups like this, I’ll err on the side of experience.

TNF Week 15 Pick: Chiefs 27, Chargers 23

Chris Harris Los Angeles Chargers CB

Can the Los Angeles Chargers beat the Kansas City Chiefs for the second time this season in their NFL Week 15 TNF showdown? (Image: USA TODAY Sports)


Thursday NFL Betting Trends for 2021

  • The Over is 5-11.
  • The Underdog is 7-9 against the spread.
  • The Favorite is 13-3 on the moneyline.
  • The Home Team is 7-9.

*Anthony Cervino is 27-18 on his NFL Best Bets for 2021 for The Game Day.


Thursday Night Football Best Bets Week 15

*NFL gameday odds and lines are current as of 2 PM ET on Thursday, December 16.

TNF Best Bet: Chiefs -3 (-120) at Caesars

Wager: 4 Units

While this matchup is close on paper, the Chiefs are the superior team. They’re also the hottest team in the NFL right now with their six-game winning streak, whereas the Chargers have been frustratingly inconsistent on a week-to-week basis.

Although Kansas City’s offense has struggled with consistency as well, they should be able to turn it on against LA’s porous defense.

Also consider:

  • The Chiefs have covered the spread in four straight games
  • The Chargers are 2-3 against the spread in their past five games

I like Kansas City -3, but would bet this up to -5.5. They should win by 6+.

spread

-120

Chiefs To Cover -3 Spread @ Chargers (TNF, NFL Week 15)

KC @ LAC | 12/16, 8:20 PM ET

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Check out more of our NFL Week 15 betting tips:


TNF Best Bet: OVER 53.5 Total Points (-110) at Caesars

Wager: 2 Units

Both of these offenses are electric, even if they haven’t always shown it this year. The Chiefs should have little trouble scoring on one of the worst defenses in the NFL, while the Chargers are capable of cooling off Kansas City’s red-hot defense.

It will rain points on TNF if both offenses are clicking. In a must-win spot for both sides, expect both clubs to keep their foot on the gas in Week 15.

Take the Over for our NFL bet of the day.

over-under

-110

Over 53.5 Total Points In Chiefs @ Chargers (TNF, NFL Week 15)

KC @ LAC | 12/16, 8:20 PM ET

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TNF Best Bet: Chiefs Moneyline (-170) at Caesars

Wager: 2 Units

I’m all-in on Kansas City here. They have the superior head coach and quarterback, plus all the momentum on their side.

While they’re on the road, I don’t think it matters in this matchup. The Chiefs have won their past five road games at the Chargers and three of their past four road games overall, and there’s nothing scary about playing in SoFI Stadium, as Chargers fans are notoriously non-existent.

spread

-170

Chiefs To Defeat Chargers (TNF, NFL Week 15)

KC @ LAC | 12/16, 8:20 PM ET

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Thanks for reading our NFL Week 15 TNF Predictions! For more NFL betting tips, check out our NFL Week 15 Best Bets and NFL Week 15 Prop Bets.

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NFL Betting News

  • Early money slightly leaning towards the over in the 49ers-Rams matchup

    DraftKings Sportsbook is reporting good two-way action on the over/under for the NFC Championship Game matchup between the San Francisco 49ers and Los Angeles Rams.

    Betting Impact:
    Per DraftKings, the over of 46 points has attracted 55% of the bets and 60% of the money thus far. Much moreso than the AFC Championship Game, the betting splits on the point spread and total in this game are much more evenly split, so the sportsbook does not have too much liability on either at the moment. From a moneyline perspective, Los Angeles's -170 moneyline odds have attracted 60% of the bets and 70% of the money.

    SF vs. LAR Game Page

  • Early bettors give slight lean to the Rams over the 49ers

    Based on the betting splits at DraftKings Sportsbook, the favored Los Angeles Rams are getting slightly more betting attention in their matchup with the San Francisco 49ers.

    Betting Impact:
    Per DraftKings, Los Angeles's -3.5 point spread has received 65% of the bets and 61% of the handle thus far. Bettors are clearly torn in this matchup considering the Rams have arguably been playing better football through the first two playoff games, while the 49ers have won six consecutive games against the Rams, including a thrilling Week 18 overtime victory in Los Angeles.

    SF vs. LAR Game Page

  • Early money more than 4/1 on the over in the Bengals-Chiefs matchup

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's over/under in the matchup between the Cincinnati Bengals and Kansas City Chiefs.

    Betting Impact:
    Per DraftKings, the over of 54.5 points has attracted 75% of the bets and 85% of the money thus far. At this point, the sportsbook has big liability to the Chiefs point spread and the over in this matchup, as their most ideal scenario would be a Bengals cover in a low-scoring game at the moment. From a moneyline perspective, Kansas City's -335 moneyline odds have attracted 58% of the bets and 61% of the money.

    CIN vs. KC Game Page

  • Early money 3/1 on the Chiefs over the Bengals

    DraftKings Sportsbook is reporting one-sided betting action for Sunday's matchup between the Cincinnati Bengals and Kansas City Chiefs, as the majority of the action is backing the favored Chiefs.

    Betting Impact:
    Per DraftKings, Kansas City's -7 point spread has received 61% of the bets and 76% of the handle thus far. Cincinnati is shaping up to be the biggest need of any side or any total this weekend, as the public seems to be enamored with the Chiefs after their thrilling Divisional Round win over Buffalo.

    CIN vs. KC Game Page

  • 49ers-Rams over/under reaches lowest number of the week

    After another line movement, the over/under for the NFC Championship matchup between the San Francisco 49ers and Los Angeles Rams has reached its lowest total of the week.

    Betting Impact:
    Per DraftKings, the 49ers-Rams over/under on Sunday night was posted at 47.5 points. It was quickly bet down to 46.5 in less than 24 hours. However, it has once again moved toward the under, and now currently sits at 46 points. Given that there has not yet been buyback on the over, it is extremely unlikely we see the total get back to anywhere close to the 47.5 points it opened at.

    SF vs. LAR Game Page