NFL’s Week 8 schedule is highlighted by an intriguing inter-conference matchup between the Cincinnati Bengals and San Francisco 49ers.
There are also a few intriguing divisional games, including the New England Patriots taking on the Miami Dolphins as well as the Kansas City Chiefs going at it with the Denver Broncos.
This is a full slate with no teams on their bye week, giving us plenty of action among these Week 8 NFL odds and lines.
NFL Week 8 Odds & Lines
Week 8 lines are courtesy of DraftKings Sportsbook and current as of Monday, October 23, at 2 p.m. ET.
Keep tabs on all of our current NFL odds leading into NFL Week 8.
NFL Week 8 Games
Tampa Bay Buccaneers @ Buffalo Bills
Oct. 26, 8:15 p.m. ET (TNF)
- Buccaneers +7 (-105) @ Bills -7 (-115)
The Bills have fallen on hard times recently, coming off a poor performance on the road in a close loss to the Patriots.
But this sets up as a bounce-back spot against a Bucs team that is struggling on offense, scoring only 19 points in their last two games.
It’s hard to see a scenario where they can keep pace with Josh Allen and company, so let’s ride with the Bills -7.5 in our NFL bet of the day.
New Orleans Saints @ Indianapolis Colts
Oct. 29, 1 p.m. ET
- Saints +1.5 (-110) @ Colts -1.5 (-110)
The Saints offense continues to struggle, with Derek Carr consistently checking it down to Alvin Kamara.
While Gardner Minshew hasn’t been great either, the Colts are much more formidable at home, where they almost knocked off the Browns in Week 7.
This game is likely to come down to the wire, so take Indianapolis -1.5 due to their home-field advantage.
Houston Texans @ Carolina Panthers
Oct. 29, 1 p.m. ET
- Texans -2.5 (-118) @ Panthers +2.5 (-102)
We’ve got a battle of two first-round rookie quarterbacks in C.J. Stroud and Bryce Young.
While Stroud has had an impressive season, leading the Texans to a surprising 3-3 record, Young has been underwhelming, with the Panthers as the only remaining winless team.
Look for Houston to get their struggling running game going against a porous Panthers rush defense en route to a victory.
Jacksonville Jaguars @ Pittsburgh Steelers
Oct. 29, 1 p.m. ET
- Jaguars -2 (-110) @ Steelers +2 (-110)
The Jaguars are now on a four-game winning streak, coming off an impressive road win on a short week in New Orleans.
Jacksonville’s defense has been one of the most improved units in the NFL.
Meanwhile, the Steelers are traveling from west to east, fresh off an upset win vs the Rams. While this game should be close, the edge goes to the Jags due to their advantage at quarterback with Trevor Lawrence over Kenny Pickett.
Minnesota Vikings @ Green Bay Packers
Oct. 29, 1 p.m. ET
- Vikings +1 (-112) @ Packers -1 (-108)
The Vikings have the edge over the Packers this week, even without Justin Jefferson.
That’s because Green Bay quarterback Jordan Love continues to struggle, establishing himself as one of the worst starters in the NFL.
Look for Kirk Cousins to lead the Vikings to a huge road win against a Packers team that is trending downward.
New York Jets @ New York Giants
Oct. 29, 1 p.m. ET
- Jets -2.5 (-118) @ Giants +2.5 (-102)
The Jets come off the bye to take on the Giants, who just knocked off the Commanders in a much-needed home win.
We’re likely to see Daniel Jones back for the G-Men, just in time to take on a tough Jets defense.
Look for the Jets to lean on stud running back Breece Hall in this exploitable matchup, resulting in a big road victory.
Los Angeles Rams @ Dallas Cowboys
Oct. 29, 1 p.m. ET
- Rams +6.5 (-108) @ Cowboys -6.5 (-112)
The Cowboys are coming off their bye, ready to take on a Rams team that has now lost four of their last six games.
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Dallas has been tough at home, winning five of their last eight games by double digits.
Look for the Cowboys to win by at least a touchdown in this spot.
Atlanta Falcons @ Tennessee Titans
Oct. 29, 1 p.m. ET
- Falcons -1 (-112) @ Titans +1 (-108)
The Falcons got a huge road win against their division rivals in the Buccaneers in Week 7. Atlanta looks to make it two in a row away from home against a Titans team coming off their bye week.
While it’s unclear who will start at quarterback for Tennessee, look for head coach Mike Vrabel to have them ready for a strong effort after the bye.
The Titans have never lost after their bye under Vrabel. Look for the Titans’ defense to cause problems for Falcons’ quarterback Desmond Ridder.
New England Patriots @ Miami Dolphins
Oct. 29, 1 p.m. ET
- Patriots +10 (-108) @ Dolphins -10 (-112)
The Dolphins got humbled by the Eagles on Sunday Night Football in a 31-17 loss.
While Miami should be able to get back on track against the Patriots, it was impressive to see New England battle back and knock off the Bills in Week 7.
This feels like too high of a number at 10 points, so ride with New England to keep it close.
Philadelphia Eagles @ Washington Commanders
Oct. 29, 1 p.m. ET
- Eagles -6.5 (-112) @ Commanders +6.5 (-108)
The Eagles got right with a 31-17 win over the Dolphins after an upset loss to the Jets, while the Commanders looked lethargic in a road defeat vs the Giants.
While these two teams played an overtime game earlier in the year, the Commanders seem to be trending downward, especially with Sam Howell taking sacks at a record pace.
That’s bad news vs the Eagles front seven, so look for Philly to cover here.
Cleveland Browns @ Seattle Seahawks
Oct. 29, 4:05 p.m. ET
- Browns +2.5 (-102) @ Seahawks -2.5 (-118)
The Browns continue to rack up wins despite poor quarterback play, led by an elite defense that forces turnovers and scores points even in down games like we saw last week vs the Colts.
Deshaun Watson is expected to suit up for this game after he left with a concussion early in Week 7.
This feels like a low-scoring battle between two stout defenses, so let’s take the Browns plus the points.
Cincinnati Bengals @ San Francisco 49ers
Oct. 29, 4:25 p.m. ET
- Bengals +5.5 (-110) @ 49ers -5.5 (-110)
The 49ers have been completely dominant at home with Brock Purdy under center, winning all seven of his starts at Levi’s Stadium, each of which were by double digits.
The Bengals are coming off their bye, so Joe Burrow may be healthier, but this is a tough matchup against an elite defense.
Take the 49ers minus the points and ride with their trend of dominance at home.
Baltimore Ravens @ Arizona Cardinals
Oct. 29, 4:25 p.m. ET
- Ravens -8 (-110) @ Cardinals +8 (-110)
Lamar Jackson is playing at an MVP level right now, fitting in perfectly in new offensive coordinator Todd Monken‘s scheme.
Kyler Murray is likely going to be out for one more week, which means that Josh Dobbs will have to take on a tough Ravens defense.
It’s hard to see how the Cardinals keep pace in this one, so roll with Baltimore -8.
Kansas City Chiefs @ Denver Broncos
Oct. 29, 4:25 p.m. ET
- Chiefs -8 (-110) @ Broncos +8 (-110)
The Chiefs offense was on cruise control in a relatively easy win over the Chargers. Patrick Mahomes torched Los Angeles for 424 yards and four touchdowns.
The Broncos got a big win over the Packers to improve to 2-5.
While Kansas City is clearly the better team here, eight points feels like too much in a road game vs a division rival, so let’s take Denver +8.
Chicago Bears @ Los Angeles Chargers
Oct. 29, 8:20 p.m. ET (SNF)
- Bears +8.5 (-110) @ Chargers -8.5 (-110)
The Chargers are in virtually a must-win situation at home after they dropped their second game in a row to fall to 2-4 on the season.
Los Angeles should be able to get it done against a struggling Bears team that will be playing with Tyson Bagent at quarterback with Justin Fields injured.
Look for the Chargers to get right with a convincing win here.
Las Vegas Raiders @ Detroit Lions
Oct. 30, 8:15 p.m. ET (MNF)
- Raiders +8 (-108) @ Lions -8 (-112)
Here we have a matchup of two teams that were blown out on the road last week.
The Raiders will be happy to get back Jimmy Garoppolo this week, as Brian Hoyer really struggled in their loss in Chicago.
Having said that, the Lions are the much better team and should get a win at home in this bounce-back spot.
