NFL Week 6 Odds

Frank AmmiranteSenior Sports Writer
Last Updated: Oct 10, 2023

In NFL Week 6, there are some fun matchups on the schedule. The Seattle Seahawks and Cincinnati Bengals should trade frequent offensive punches. And we may get a measure of how ready the Cleveland Browns are for contention when they face the San Francisco 49ers.

Brian Daboll faces his former team as the New York Giants take on the Buffalo Bills. The most talked-about matchup, though, will surely be the one that features the Dallas Cowboys and the Los Angeles Chargers.

Two teams will be on byes in Week 6: the Green Bay Packers and Pittsburgh Steelers.

NFL Week 6 Odds & Lines

Week 6 lines are courtesy of DraftKings Sportsbook and are current as of October 10, 2023, at 9 a.m. ET.

Keep tabs on all of our current NFL odds leading into NFL Week 1.

NFL Week 6 Games

Denver Broncos @ Kansas City Chiefs

Oct. 12th, 8:15 p.m. ET (TNF)

  • Broncos +10.5 (-112) @ Chiefs -10.5 (-108)

The Chiefs have defeated the Broncos 15 consecutive times, but the last three meetings have had winning margins of six points or fewer, so we could see Denver keep it close here.

Russell Wilson had some success against the Chiefs last year, throwing for four touchdowns and rushing for another two.

Look for Kansas City to win this game, but Denver should cover the spread.

Baltimore Ravens @ Tennessee Titans

Oct. 15th, 9:30 a.m. ET (London)

  • Ravens -3.5 (-110) @ Titans +3.5 (-110)

The Ravens head to London with a 3-2 record and Lamar Jackson playing at a high level. The star quarterback ranks second in PFF grade, showing comfort in Todd Monken‘s offensive scheme.

This is a tough Ravens defense that currently ranks second in DVOA, so Ryan Tannehill and company may have a difficult time moving the ball.

Take Baltimore -3.5 due to their advantages on both sides of the ball.

Seattle Seahawks @ Cincinnati Bengals

Oct. 15th, 1 p.m. ET

  • Seahawks +2.5 (-102) @ Bengals -2.5 (-118)

The Seahawks come off their bye having won three games in a row, while the Bengals got a much-needed victory in Arizona.

Joe Burrow looked significantly better last week, completing 36 of 46 passes for 317 yards and three touchdowns. That’s an encouraging sign as he continues to heal from his calf injury.

This shapes up as a potentially close game, but give me Cincinnati -2.5 due to their home-field advantage.

Carolina Panthers @ Miami Dolphins

Oct. 15th, 1 p.m. ET

  • Panthers +13.5 (-108) @ Dolphins -13.5 (-112)

Here we have a clear mismatch between a winless Panthers team with a struggling rookie quarterback in Bryce Young and an elite offense that continues to fire on all cylinders.

It’s hard to see a scenario where Young can keep pace with the likes of Tua Tagovailoa, Tyreek Hill, and Jaylen Waddle in this spot.

Take the Dolphins to cover, even at a high number of 13.5 points.

New Orleans Saints @ Houston Texans

Oct. 15th, 1 p.m. ET

  • Saints -1.5 (-110) @ Texans +1.5 (-110)

The Saints head to Houston following an impressive 34-0 victory against the Patriots, but I’m taking the Texans because of the quarterbacking advantage that C.J. Stroud has over Derek Carr.

The Texans’ rookie has been terrific this season, throwing for 1,461 yards with seven touchdowns and zero interceptions.

Look for Stroud to lead Houston to a win as home underdogs here.

Washington Commanders @ Atlanta Falcons

Oct. 15th, 1 p.m. ET

  • Commanders +2.5 (-102) @ Falcons -2.5 (-118)

The Commanders are coming off an embarrassing home loss to the Bears on Thursday Night Football. Expect Washington to put forth a much better effort against Atlanta in Week 6.

Falcons quarterback Desmond Ridder had his best game of the season vs the Texans, throwing for 329 yards and one touchdown, but look for him to have some challenges against the strong pass rush of the Commanders.

Take Washington plus the points in this spot.

Minnesota Vikings @ Chicago Bears

Oct. 15th, 1 p.m. ET

  • Vikings -2.5 (-112) @ Bears +2.5 (-112)

The Vikings got some bad news with superstar wideout Justin Jefferson heading to the injured reserve.

Minnesota will be in tough against an improving Chicago offense led by Justin Fields, who has thrown for 617 yards and eight touchdowns in his last two games.

The Bears look like live dogs here, so take them at +2.5.

Detroit Lions @ Tampa Bay Buccaneers

Oct. 15th, 1 p.m. ET

  • Lions -3 (-115) @ Buccaneers +3 (-105)

The Lions continue to deliver on lofty preseason expectations, winning four of their first five games, including a blowout victory over the Panthers last week.

The Bucs have been a surprise team, getting off to a respectable 3-1 start.

Tampa Bay is coming off a bye and could pull off the upset here, making Bucs +3 look like a strong play.

San Francisco 49ers @ Cleveland Browns

Oct. 15th, 1 p.m. ET

  • 49ers -5 (-112) @ Browns +5 (-108)

This looks like a letdown spot for the undefeated 49ers after a decisive win against the Cowboys.

Coming off the bye, the Browns should have a healthy Deshaun Watson and will be led by an imposing defense that ranks first in DVOA.

San Francisco may still manage an outright win here, but five points feels like too many.

Indianapolis Colts @ Jacksonville Jaguars

Oct. 15th, 1 p.m. ET

  • Colts +3.5 (-108) @ Jaguars -3.5 (-112)

Here we have the Gardner Minshew revenge game against his former team, as Anthony Richardson is sidelined with a shoulder injury.

Jacksonville is coming off consecutive wins in London, including an impressive victory over the Bills.

This feels like a letdown spot for them in a game that should come down to a last-minute field goal, making Colts +3.5 look like the preferred play.

New England Patriots @ Las Vegas Raiders

Oct. 15th, 4:05 p.m. ET

  • Patriots +3 (-110) @ Raiders -3 (-110)

The Patriots have been outscored 72-3 in their current two-game losing streak, but they’re only three-point road underdogs to the Raiders, who just knocked off the Packers on Monday Night Football.

This sets up as a “buy-low" spot for the Patriots, as they’re not as bad as they’ve looked in the last two games. By no means is New England a playoff contender, but there are certainly worse teams in the league.

Look for head coach Bill Belichick to have his troops ready to give a much better effort in Las Vegas.

Philadelphia Eagles @ New York Jets

Oct. 15th, 4:25 p.m. ET

  • Eagles -7 (-105) @ Jets +7 (-115)

The Eagles are seven-point road favorites against the Jets, but this feels like too many points against a tough defense.

New York is currently 1-2 at home, with a win over Buffalo and close losses to New England (five points) and Kansas City (three).

Zach Wilson hasn’t been nearly as bad in the last two games, so we’ll take the Jets as home underdogs here.

Arizona Cardinals @ Los Angeles Rams

Oct. 15th, 4:25 p.m. ET

  • Cardinals +6.5 (-115) @ Rams -6.5 (-105)

The Rams dropped the first of their three-game homestand against the Eagles, but they should get it done against the Cardinals.

We saw Joshua Dobbs start to come back to Earth last week, throwing for only 166 yards and two interceptions while taking three sacks.

Meanwhile, the Rams have all hands on deck with Cooper Kupp back in the fold. Look for a double-digit win for Sean McVay‘s squad.

New York Giants @ Buffalo Bills

Oct. 15th, 8:20 p.m. ET (SNF)

  • Giants +14 (-110) @ Bills -14 (-110)

Tyrod Taylor will be starting for the Giants since Daniel Jones is out with an injury, so it’s a double-revenge game with Taylor and head coach Brian Daboll facing their former team.

That narrative doesn’t mean much, though, as the Giants’ offensive line continues to struggle, which will make it tough for New York to keep up with Josh Allen and his weapons.

Look for the Bills to win this one by 14 to 20 points.

Dallas Cowboys @ Los Angeles Chargers

Oct. 16th, 8:15 p.m. ET (MNF)

  • Cowboys -2 (-110) @ Chargers +2 (-110)

This sets up as a bounce-back spot for a Cowboys team that just got trounced by the 49ers on Sunday Night Football.

The Chargers are lacking a big-play element to their passing attack with Mike Williams out for the season. That’s going to hurt them against a tough Dallas defense.

We should see a close, high-scoring game here, but the Cowboys are the better team, so ride with them -2.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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