NFL Week 6 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Week 6 presents the first bye weeks of the 2022 NFL season, as the Lions, Raiders, Texans, and Titans will have the week off to regroup and refocus.

In fact, we won’t have another full 16-game slate until Week 15, so now is the time to really hone in on your process and start finding some value.

Here are the current Week 6 NFL odds and lines for the 2022 season.

NFL Week 6 Odds & Lines

Week 6 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Monday, July 18 at 11:00 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 6.

NFL Week 6 Games

Washington Commanders @ Chicago Bears (Thursday Night Football)

Commanders -1.5 (-110) @ Bears +1.5 (-110)

This has all the makings of a Thursday Night Football clunker. It’s the only game on, so we’ll probably find a reason to pick a side, but it’s not one we’re marking our calendars for.

Home sides do tend to be better on a short week, though.

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San Francisco 49ers @ Atlanta Falcons (Oct. 16, 1 p.m. ET)

49ers -6.5 (-110) @ Falcons +6.5 (-110) 

The Falcons will be looking for a quarterback like Trey Lance in next year’s NFL Draft. The 49ers should win this game pretty comfortably.

New York Jets @ Green Bay Packers

Jets +9.5 (-110) @ Packers -9.5 (-110)

After facing the Giants across the pond in Week 5, the Packers return home to take on another mediocre New York squad in Week 6. The Jets haven’t beaten Green Bay since 2006, and that probably won’t change this week. Still, this seems like a big number to cover.

Jacksonville Jaguars @ Indianapolis Colts

Jaguars +7 (-110) @ Colts -7 (-110)

The Colts and Jaguars square off for the second time in a month after rekindling their AFC South rivalry in Jacksonville in Week 2. The Jags haven’t won in Indy since 2017, but covering this spread doesn’t seem outside the realm of possibility.

Minnesota Vikings @ Miami Dolphins

Vikings +3 (-110) @ Dolphins -3 (-110)

The Dolphins lead the all-time series against the Vikings 8-5 and got the all-important 24-7 victory in Super Bowl VIII back in 1974. This matchup should feature a lot more points, but I’d still expect Miami to come out on top at home.

Cincinnati Bengals @ New Orleans Saints

Bengals -1 (-110) @ Saints +1 (-110)

The Saints have one of the better defenses in the NFL, but slowing down Joe Burrow and co. is no easy task. This spread feels like it should be larger.

Baltimore Ravens @ New York Giants

Ravens -3.5 (-110) @ Giants +3.5 (-110)

The Ravens have won five of seven all-time meetings against the Giants, including a 34-7 victory in Super Bowl 35, and four of those results came by 14 points or more. This Baltimore squad is way better than New York, but the odds aren’t reflecting that here. Back Lamar Jackson and the Ravens to cover this short spread.

Tampa Bay Buccaneers @ Pittsburgh Steelers

Buccaneers -5.5 (-110) @ Steelers +5.5 (-110)

Steelers fans probably thought they had seen the last of Tom Brady when he left New England, but the former Patriots quarterback will get one more chance to torture Pittsburgh and its fans. Brady owns a 12-3 record against the Steelers, including three AFC Championship Game victories, and should improve on that mark here.

New England Patriots @ Cleveland Browns

Patriots N/A @ Browns N/A

Depending on the length of Deshaun Watson‘s suspension, there’s a chance that this could be the last game he sits out. That would be welcome news for Cleveland’s postseason odds, but I don’t really like the Browns’ chances in this one if Jacoby Brissett is taking on his former team.

Carolina Panthers @ Los Angeles Rams (Oct. 16, 4:05 p.m. ET)

Panthers +7.5 (-110) @ Rams -7.5 (-110)

Six of the Rams’ 12 wins last year came by double digits, so there’s no reason to think Matthew Stafford and co. can’t run up the score against an underwhelming Panthers’ squad.

Arizona Cardinals @ Seattle Seahawks

Cardinals -2.5 (-110) @ Seahawks +2.5 (-110) 

The Seahawks and Cardinals split their season series last year, with the road team emerging victorious on both occasions. Depending on how both teams have looked over the opening month of this season, Seattle could be an intriguing home underdog here.

Buffalo Bills @ Kansas City Chiefs

Bills -1.5 (-110) @ Chiefs +1.5 (-110)

The headliner of Week 6 is a rematch of one of the best games in NFL history. The Bills/Chiefs overtime thriller in last year’s playoffs was so good that it literally forced the league to change the postseason rules, making sure both teams get a chance to touch the ball in overtime.

Josh Allen and Patrick Mahomes are as good as it gets, but the Bills are the better all-around squad. Back Buffalo as your NFL pick of the day.

Dallas Cowboys @ Philadelphia Eagles (Sunday Night Football)

Cowboys PICK (-110) @ Eagles PICK (-110)

The Cowboys have won three straight games against the Eagles by a combined score of 129-64. That’s good for an average of 43 points per game. Until Philadelphia proves that they can hang with their NFC East rival, I’m rolling with Dak Prescott and Dallas.

Denver Broncos @ Los Angeles Chargers (Monday Night Football)

Broncos +3 (+100) @ Chargers -3 (-120)

The AFC West is going to be must-watch television all season long, and we get a special primetime showcase in Week 6 between the two teams looking to unseat the Chiefs in the division. This spread feels about right, so just buckle up and watch Justin Herbert and Russell Wilson put on a show.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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