NFL Week 6 Odds & Opening Lines

Last Updated: Oct 11, 2022

Week 6 presents the first bye weeks of the 2022 NFL season, as the Lions, Raiders, Texans, and Titans will have the week off to regroup and refocus.

In fact, we won’t have another full 16-game slate until Week 15, so now is the time to really hone in on our betting process and start finding some early-week value.

Here are the current Week 6 NFL odds and lines for the 2022 season.

NFL Week 6 Odds & Lines

Week 6 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Oct. 10 at 11:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 6.

NFL Week 6 Games

Washington Commanders @ Chicago Bears (Thursday Night Football)

Commanders -1 (-108) @ Bears +1 (-112)

This has all the makings of a Thursday Night Football clunker. It’s the only game on, so we’ll probably find a reason to pick a side, but it’s not one we’re marking our calendars for.

Home sides do tend to be better on a short week, though.

San Francisco 49ers @ Atlanta Falcons (Oct. 16, 1 p.m. ET)

49ers -6 (-105) @ Falcons +6 (-115)

The 49ers’ defense should have be able to shut down the Falcons, much like Tampa Bay did for three-plus quarters on Sunday. Atlanta is the last unbeaten team in the NFL against the spread, but that could come to an end on Sunday.

New York Jets @ Green Bay Packers

Jets +7 (-105) @ Packers -7 (-115)

After losing to the Giants across the pond in Week 5, the Packers return home to take on another overachieving New York squad in Week 6. The Jets haven’t beaten Green Bay since 2006, and that probably won’t change this week.

Still, this seems like a big number to cover.

Jacksonville Jaguars @ Indianapolis Colts

Jaguars +1.5 (-110) @ Colts -1.5 (-110)

The Colts and Jaguars square off for the second time in a month after rekindling their AFC South rivalry in Week 2. Jacksonville shut out Matt Ryan and co. in that game.

The Jags haven’t won in Indy since 2017. I’d expect the Colts to get their revenge at home, especially with extra rest after winning on Thursday night.

Minnesota Vikings @ Miami Dolphins

Vikings -3 (-106) @ Dolphins +3 (-114)

After a 3-0 start, the Dolphins have dropped back-to-back games after third-string quarterback Skylar Thompson was forced into action for the majority of their Week 5 loss to the Jets. If Tua Tagovailoa (head/neck) or Teddy Bridgewater (concussion) can’t go, this will be an uphill battle.

Cincinnati Bengals @ New Orleans Saints

Bengals -1.5 (-110) @ Saints +1.5 (-110)

This should be a good bounce-back spot for Joe Burrow and the Bengals after suffering a last-second loss on Sunday Night Football. The Saints got a much-needed victory on Sunday against Seattle, but you can’t expect Taysom Hill to account for four touchdowns every week.

Back Cincinnati on the road with confidence.

Baltimore Ravens @ New York Giants

Ravens -5.5 (-104) @ Giants +5.5 (-118)

The Ravens have won five of seven all-time meetings against the Giants, including a 34-7 triumph in Super Bowl 35, and four of those victories came by 14 points or more. Big Blue somehow enters this matchup with a better record than Baltimore, but oddsmakers know who the better team is.

With a spread of 5.5, this is probably New York or nothing, but I’d probably stay away.

Tampa Bay Buccaneers @ Pittsburgh Steelers

Buccaneers -8 (-110) @ Steelers +8 (-110)

Steelers fans probably thought they had seen the last of Tom Brady when he left New England, but the former Patriots quarterback will get one more chance to torture Pittsburgh and its fans in Week 6.

Brady owns a 12-3 record against the Steelers, including three AFC Championship Game victories, and should improve on that mark here against Kenny Pickett.

New England Patriots @ Cleveland Browns

Patriots +3 (-110) @ Browns -3 (-110)

After throwing a critical fourth-quarter interception in a Week 5 loss to the Chargers, Jacoby Brissett will try to turn things around when he takes on his former team. New England’s defense is coming off a 29-0 shutout of the Lions, so moving the ball won’t be easy.

The Patriots could also get quarterback Mac Jones (ankle) back for this game, though Bailey Zappe looked fine in his first NFL start. I’d take the points with New England in this spot.

Carolina Panthers @ Los Angeles Rams (Oct. 16, 4:05 p.m. ET)

Panthers +9.5 (-110) @ Rams -9.5 (-110)

It’s hard to back the Rams based on how they’ve played this season, but I can’t put real money on this Carolina team. Whether it’s Baker Mayfield or P.J. Walker starting at quarterback, it’s hard to imagine the Panthers putting up points.

Six of the LA’s 12 wins last year came by double digits, so Matthew Stafford and co. are certainly capable of running up the score against a reeling Carolina squad.

Arizona Cardinals @ Seattle Seahawks

Cardinals -3 (-105) @ Seahawks +3 (-115)

The Seahawks and Cardinals split their season series last year, with the road team emerging victorious on both occasions. Geno Smith and Seattle are much better than we all thought, but this defense is a mess.

Backing a Kliff Kingsbury-coached team is a scary thought, however, Arizona seems to play better on its travels. Get in on the Cards before this hits a key number.

Buffalo Bills @ Kansas City Chiefs

Bills -1.5 (-110) @ Chiefs +1.5 (-110)

The headline matchup of Week 6 is a rematch of one of the best games in NFL history. The Bills-Chiefs overtime thriller in last year’s playoffs was so good that it literally forced the league to change the postseason rules, making sure both teams get a chance to touch the ball in overtime.

Josh Allen and Patrick Mahomes are as good as it gets, but I’m backing Buffalo to get its revenge as my NFL pick of the day.

Dallas Cowboys @ Philadelphia Eagles (Sunday Night Football)

Cowboys +5.5 (-114) @ Eagles -5.5 (-106)

The Cowboys have won three straight games against the Eagles by a combined score of 129-64. That’s good for an average of 43 points per game. Whether Dak Prescott makes his return or Dallas continues with Cooper Rush, it’s hard to imagine the visitors putting up 40+ points.

Still, taking the points with the Cowboys is probably the prudent play.

Denver Broncos @ Los Angeles Chargers (Monday Night Football)

Broncos +6 (-110) @ Chargers -6 (-110)

Yes, we really have to watch the Broncos play primetime football again.

And you know what’s worse? I have to take the points here with Denver. Things are never as good or as bad as they seem in the NFL, and the Chargers shouldn’t be this big of a favorite on MNF. It’s ugly, but the Broncos are the right side.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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