The NFL Week 5 slate includes some compelling featured clashes. The day begins in London with a top AFC matchup between the Jacksonville Jaguars and Buffalo Bills.
Later on Sunday, the Kansas City Chiefs and Minnesota Vikings should be an exciting game to wager on and watch. On Sunday night, the Dallas Cowboys and San Francisco 49ers will meet up in the NFC’s prime showdown of the week.
Four teams will be on byes in Week 5: Cleveland Browns, Los Angeles Chargers, Tampa Bay Buccaneers, and Seattle Seahawks.
NFL Week 5 Odds & Lines
Week 5 lines are courtesy of DraftKings Sportsbook and are current as of Monday, October 2, at noon.
Keep tabs on all of our current NFL odds leading into NFL Week 5.
NFL Week 5 Games
Chicago Bears @ Washington Commanders
Oct. 5, 8:15 p.m. ET (TNF)
- Bears +7 (-110) @ Commanders -7 (-110)
The Bears blew a 28-7 lead to the Broncos last week, but Justin Fields came alive with 335 yards and four touchdowns.
The Commanders had a tough overtime loss to the Eagles, making this look like a letdown spot in a short week on Thursday Night Football.
Washington often plays down to their competition — look at Week 1 vs the Cardinals — so we could have a closer game than expected.
Jacksonville Jaguars @ Buffalo Bills
Oct. 8, 9:30 a.m. ET (London)
- Jaguars +6 (-112) Bills -6 (-108)
The Jaguars play in London for the second consecutive week, while the Bills must travel across the pond.
This isn’t a big deal because the real edge lies in Josh Allen vs a Jaguars defense that has struggled to get to the quarterback.
Buffalo looks like the best team in the AFC following three consecutive blowout wins, including one against the Dolphins, so lay the points here.
Baltimore Ravens @ Pittsburgh Steelers
Oct. 8, 1 p.m. ET
- Ravens -4.5 (-110) @ Steelers +4.5 (-110)
This will be the third divisional game for the Ravens in the first five weeks. The Steelers are coming off a tough loss to the Texans, where they lost starting quarterback Kenny Pickett to injury.
Pickett (knee) will be out for this game, meaning Mitchell Trubisky will be under center.
Pittsburgh will have a tough time keeping pace with Lamar Jackson here, so lay the points with the Ravens.
Houston Texans @ Atlanta Falcons
Oct. 8, 1 p.m. ET
- Texans -1 (-105) @ Falcons +1 (-115)
Texans’ rookie quarterback C.J. Stroud continues to turn heads, coming off consecutive wins over the Jaguars and Steelers.
Stroud has combined for 950 passing yards with six touchdowns and zero interceptions in his last three games.
Meanwhile, Falcons’ starter Desmond Ridder continues to struggle, getting sacked 11 times in his last two games with two interceptions and two fumbles. Look for the Texans to get a win here.
Tennessee Titans @ Indianapolis Colts
Oct. 8, 1 p.m. ET
- Titans +1 (-108) @ Colts -1 (-112)
The Titans are coming off a convincing win over a struggling Bengals team, while the Colts almost completed an epic comeback in their overtime loss to the Rams.
You have to be impressed with Colts’ rookie Anthony Richardson so far, showing resilience by overcoming a 23-0 deficit to force overtime vs Los Angeles.
Titans’ quarterback Ryan Tannehill has struggled, throwing two touchdowns with four interceptions. Tennessee’s offense looks pretty vanilla compared to Shane Steichen‘s unit with the Colts. Give me Indy at the short number at home.
New York Giants @ Miami Dolphins
Oct. 8, 1 p.m. ET
- Giants +9.5 (-110) @ Dolphins -9.5 (-110)
This sets up as a bounce-back spot for the Dolphins, who got crushed by the Bills 48-20 in a pivotal AFC East showdown.
It will be tough for Daniel Jones and company to keep pace with this electric Miami offense, which has just unleashed a new weapon in rookie running back De’Von Achane.
Lay the points and take Dolphins -9.5 here.
New Orleans Saints @ New England Patriots
Oct. 8, 1 p.m. ET
- Saints +1.5 (-108) @ Patriots -1.5 (-112)
Here, we have an inter-conference game that looks like a low-scoring affair between two struggling offenses.
Derek Carr was clearly affected by his shoulder injury in a 26-9 loss to the Bucs, throwing for only 127 yards on 37 attempts. Mac Jones was benched for Bailey Zappe in a 38-3 loss to the Cowboys.
The Saints have much more talent on offense, especially with Alvin Kamara back, so New Orleans +1.5 looks like the prudent play.
Carolina Panthers @ Detroit Lions
Oct. 8, 1 p.m. ET
- Panthers +9 (-110) @ Lions -9 (-110)
The Panthers offense continues to struggle under rookie quarterback Bryce Young, who is now averaging only 4.9 yards per attempt on the season.
Detroit continues to look like one of the best teams in the NFC, with an improving defense led by standout pass-rusher Aidan Hutchinson.
While nine points is a lot to lay with the Lions, this feels like the better play than relying on Young on the road.
Cincinnati Bengals @ Arizona Cardinals
Oct. 8, 4:05 p.m. ET
- Bengals -3 (-118) @ Cardinals +3 (-102)
The Cardinals continue to shock the NFL world by remaining competitive without Kyler Murray. Interim starter Joshua Dobbs has played well in Murray’s absence, completing over 70% of his passes with zero interceptions.
Meanwhile, Joe Burrow continues to be affected by the calf injury, coming off another dud, this time against the Titans. Burrow threw for only 165 yards on 30 passes, putting his yards per attempt down to an abysmal 4.8.
It’s crazy to say this, but Arizona’s offense is functioning at a higher level right now. Add in homefield advantage, and Cardinals +3 looks like the better play.
Philadelphia Eagles @ Los Angeles Rams
Oct. 8, 4:05 p.m. ET
- Eagles -4.5 (-110) @ Rams +4.5 (-110)
The last two NFC champions meet in a game where the Rams can continue to show they have regained some respectability. The Eagles would like to take this one following a hard-fought overtime win to the Commanders.
Matthew Stafford looks back in form for the Rams, while Puka Nacua continues to have a phenomenal rookie season.
Philly’s passing game came alive against the Commanders, but Los Angeles has a better pass defense so far. This feels like a close game, given how the Rams’ offense has performed this year, so take Los Angeles +4.5.
Kansas City Chiefs @ Minnesota Vikings
Oct. 8, 4:25 p.m. ET
- Chiefs -5.5 (-110) @ Vikings +5.5 (-110)
Here, we have a major mismatch between the best quarterback in football, Patrick Mahomes, taking on a lackluster Vikings’ defense that has a weak pass rush.
We should see Mahomes have a clean pocket to go to work and pick apart this secondary. While this looks like a high-scoring game, Kansas City has a clear edge in this one.
Take the Chiefs to win by six or more points in Minnesota.
New York Jets @ Denver Broncos
Oct. 8, 4:25 p.m. ET
- Jets +2.5 (-105) @ Broncos -2.5 (-115)
Jets’ quarterback Zach Wilson looks to build on an impressive performance against the Chiefs. This is a terrific matchup vs the Broncos, who have easily the worst defense in the NFL right now.
However, I’m not ready to buy into Wilson just off one performance. On the other side, Russell Wilson has played well under Sean Payton, leading a comeback win over the Bears last week.
Don’t overreact to the Jets’ game on Sunday Night Football. Roll with the Broncos -2.5.
Dallas Cowboys @ San Francisco 49ers
Oct. 8, 8:20 p.m. ET (SNF)
- Cowboys +3.5 (-112) @ 49ers -3.5 (-108)
This premier NFC rivalry resumes after the 49ers ended the Cowboys’ season in the Divisional Round of the playoffs last year. Dallas is once again one of the better teams in the NFC, but San Francisco looks like the best team in the NFL.
The 49ers are undefeated in Brock Purdy’s starts, where he finishes the game. San Fran has won seven of eight home games with Purdy by at least double-digits.
For that reason, this number looks too low at 3.5 points, so take the Niners here and bet on their trend of recent success at home with Purdy under center.
Green Bay Packers @ Las Vegas Raiders
Oct. 9, 8:15 p.m. ET (MNF)
- Packers -2.5 (-110) @ Raiders +2.5 (-110)
Jordan Love is coming off a poor performance on Thursday Night Football in Green Bay’s loss to the Lions, while the Raiders have now lost three in a row.
Jimmy Garoppolo (concussion) should be able to return for this game. This is Davante Adams‘ first game against his former team, but Green Bay has a tough pass defense that could get back top corner Jaire Alexander for this one.
Take the better team on the road with Green Bay -2.5.
