NFL Week 5 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Frank AmmiranteFantasy Sports & Betting Writer
Posted: Jul 12, 2022Last updated: Aug 5, 2022

Week 5 of the 2022 NFL season offers up six divisional matchups, including a fascinating AFC North showdown between Joe Burrow‘s Bengals and Lamar Jackson‘s Ravens on Sunday Night Football.

We’ve also got our second straight week of international games, as the Green Bay Packers will take on the New York Giants at Tottenham Hotspur Stadium in London.

Here are the current Week 5 NFL odds and lines for the 2022 season.

NFL Week 5 Odds & Lines

Week 5 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Tuesday, July 12 at 5 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 5.

NFL Week 5 Games

Indianapolis Colts @ Denver Broncos (TNF)

Colts +3 (-110) @ Broncos -3 (-110)

It’s a battle of two veteran quarterbacks as Matt Ryan and the Colts head to Denver to take on Russell Wilson and the Broncos in a pivotal AFC matchup between two playoff contenders.

You have to give the slight edge to Denver here, especially since they’re at home. They’ve been “one quarterback away" for the last two years, and now they have a stud in Wilson. It’ll be tough for Ryan and the Colts’ passing game to keep pace here.

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New York Giants @ Green Bay Packers (Oct. 9, 10:30 a.m. ET - London)

Giants +7 (-110) @ Packers -7 (-110) 

The Giants take on the Packers in London as 7-point underdogs, demonstrating the disparity between these two teams with such a high spread at a neutral site. Green Bay will move forward without star wideout Davante Adams, but they’re still a contender as long as Aaron Rodgers is there.

While New York should be improved with an upgraded coaching staff led by Brian Daboll, it’s hard to see them hanging with Rodgers and company. Look for Green Bay to cover the points here.

Pittsburgh Steelers @ Buffalo Bills (Oct. 9, 1 p.m. ET)

Steelers +9.5 (-110) @ Bills -9.5 (-110) 

The Bills are one of the Super Bowl favorites this season. Led by Josh Allen and an improving defense, this team is going to be tough to beat. They should be able to cover the 9.5-point spread against Mitch Trubisky or Kenny Pickett and the Steelers.

While Pittsburgh has always been a scrappy opponent under Mike Tomlin, they don’t have the firepower to keep pace with this high-octane Bills’ offense.

Houston Texans @ Jacksonville Jaguars

Texans +3.5 (-110) @ Jaguars -3.5 (-110)

Here we have a divisional clash between two of 2021’s bottom-feeders, but the Jaguars have the superior supporting cast. Let’s not forget that Trevor Lawrence was a generational quarterback prospect, one who should see dramatic improvements under competent coaching with Doug Pederson.

While second-year quarterback Davis Mills surprised many observers, the Texans have an unproven supporting cast outside of Brandin Cooks. Look for the Jaguars to win by a touchdown here.

Chicago Bears @ Minnesota Vikings

Bears +6 (-110) @ Vikings -6 (-110)

Bears’ second-year quarterback Justin Fields should show improvements while playing in a scheme that caters to his strengths, but they’re in tough against a Vikings team on the rise. New Minnesota head coach Kevin O’Connell should be able to unlock more out of this offense.

Look for Justin Jefferson and this passing game to excel this year. Chicago is expected to be a run-heavy team, making it tough for them to win this one on the road. Minnesota simply has too many weapons.

Detroit Lions @ New England Patriots

Lions +6.5 (-110) @ Patriots -6.5 (-110)

The Lions are projected to be one of the surprise teams this season, boasting a talented offensive line along with an assortment of playmakers that includes star running back D’Andre Swift. However, they’ll be in a tough spot against Mac Jones and the Patriots.

New England had one of the best point differentials in football last season, which indicates that we may be sleeping on them a bit this year. They should still remain playoff contenders despite playing in an improved division.

Seattle Seahawks @ New Orleans Saints

Seahawks +6 (-110) @ Saints -6 (-110)

The Seahawks have one of the worst quarterback situations in the league with Drew Lock and Geno Smith. They’re going to be an extremely run-heavy offense, which is bad news against a Saints’ defense that excels at stopping the run.

New Orleans could be a playoff contender, especially with Michael Thomas returning and rookie Chris Olave entering the fold.

Miami Dolphins @ New York Jets

Dolphins -2.5 (-110) @ Jets +2.5 (-110)

Here we have a clash of division rivals with improved supporting casts. Tua Tagovailoa is in a terrific situation, throwing passes to Tyreek HillJaylen Waddle, and Chase Edmonds, while coached up by a brilliant offensive mind in Mike McDaniel.

Zach Wilson is surrounded by blue-chip talents like Elijah MooreGarrett Wilson, and Breece Hall. This should be an exciting game that could go down to the wire.

Atlanta Falcons @ Tampa Bay Buccaneers

Falcons +10.5 (-110) @ Buccaneers -10.5 (-110) 

The Falcons have some exciting pieces like Kyle Pitts and Drake London, but they project to be among the worst teams in the NFL this season. It’s going to be tough for Marcus Mariota to keep pace with Tom Brady and this prolific passing game.

While the Bucs’ supporting cast isn’t as strong as it’s been in recent years, they should cruise to victory against their inferior division rivals.

Los Angeles Chargers @ Cleveland Browns

Chargers N/A @ Browns N/A

The Chargers look like sneaky Super Bowl contenders, as they have all the pieces in place to make a run. Franchise quarterback Justin Herbert continues to improve and he’s surrounded by a ton of talent that includes Austin Ekeler, Keenan Allen, and Mike Williams. Meanwhile, the defense added Khalil Mack.

The Browns are expected to be without Deshaun Watson here, as it’s likely that his suspension is for at least six games. It’s hard to see them knocking off the Chargers with Jacoby Brissett at the helm.

Tennessee Titans @ Washington Commanders

Titans PICK (-110) @ Commanders PICK (-110) 

The Titans lost A.J. Brown, but they replaced him with a stud rookie in Treylon Burks while also adding veterans Robert Woods and Austin Hooper. This has always been a scrappy team under head coach Mike Vrabel.

The Commanders hope that Carson Wentz could rediscover his early-career magic. They also need their defense to get back to form, led by Chase Young. This has the look of a hard-nosed, low-scoring battle that comes down to a last-minute field goal.

San Francisco 49ers @ Carolina Panthers (Oct. 9, 4:05 p.m. ET)

49ers -2.5 (-110) @ Panthers +2.5 (-110)

The 49ers hand over the reins to second-year quarterback Trey Lance, a dual-threat passer who can unlock more out of this offense. They remain Super Bowl contenders due to their stacked roster.

Baker Mayfield could help this Panthers’ offense reach the next level while the defense continues to improve. This was a huge addition that could elevate them to playoff contention. While they could pull off an upset here, I’d roll with the 49ers as short road favorites, given their superior talent on both sides of the ball.

Philadelphia Eagles @ Arizona Cardinals

Eagles +2 (-110) @ Cardinals -2 (-110)

The Eagles have an exciting roster, surrounding Jalen Hurts with talented players like A.J. BrownDeVonta Smith, and Dallas Goedert. They’re firmly in play for the NFC East division title this year.

The Cardinals added Marquise Brown, but they’ll be without DeAndre Hopkins for this game, as he’ll still be serving his six-game suspension. That gives the edge to the Eagles here, especially since they have a more well-rounded roster.

Dallas Cowboys @ Los Angeles Rams

Cowboys +4.5 (-110) @ Rams -4.5 (-110)

The Cowboys shipped away Amari Cooper, but this is still a talented offense that includes CeeDee LambDalton Schultz, and Ezekiel Elliott. The defense is stacked with young talent like Micah Parsons and Trevon Diggs.

However, it’s tough to see them knocking off the defending Super Bowl champions in their house. Los Angeles added Allen Robinson, who gives them arguably an improved supporting cast over last year’s edition. Year 2 for Matthew Stafford in Sean McVay‘s offense should be exciting. Look for the Rams to get it done here.

Cincinnati Bengals @ Baltimore Ravens (Sunday Night Football)

Bengals +1 (-110) @ Ravens -1 (-110)

The Bengals come into this season with a fully healthy Burrow, ready to unleash him, especially since they have dramatically improved their offensive line. The team won’t have to waste time easing in their franchise quarterback like they did last year when he was coming off a torn ACL.

The Ravens get back Jackson, likely going back to more of a run-heavy offense. They had trouble with this Bengals’ passing game last season, and I’ll bet on that continuing in 2022. Take Cincinnati as short underdogs here as your NFL pick of the day.

Las Vegas Raiders @ Kansas City Chiefs (Monday Night Football)

Raiders +6 (-110) @ Chiefs -6 (-110)

The Raiders look to make a statement with their new-looked team that features stars like Adams and Chandler Jones. This is a pivotal divisional matchup against a Chiefs’ offense that replaced Tyreek Hill with JuJu Smith-SchusterSkyy Moore, and Marquez Valdes-Scantling.

This has the makings of a shootout that ends up as a one-score game, so it’s probably best to take the Raiders and the points. The AFC West should be a sight to behold this season.


Frank Ammirante

Before joining The Game Day, Frank spent three years in the fantasy sports and betting industry, writing for websites like RotoBaller and 4for4football. Frank is an active member of the fantasy baseball and fantasy football community, participating in high-stakes leagues like NFBC/NFFC as well as industry competitions like Scott Fish Bowl, RazzBowl, and TGFBI. Frank is a member of the FSWA and IBWAA. Give him a shout to talk fantasy sports and sports betting.

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