NFL Week 5 Odds & Opening Lines

Last Updated: Jan 23, 2023

Week 5 of the 2022 NFL season offers up six divisional matchups, including a fascinating AFC North showdown between Joe Burrow‘s Bengals and Lamar Jackson‘s Ravens on Sunday Night Football.

We’ve also got our second straight week of international games, as the Green Bay Packers will take on the New York Giants at Tottenham Hotspur Stadium in London.

Here are the current Week 5 NFL odds and lines for the 2022 season.

NFL Week 5 Odds & Lines

Week 5 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Oct. 3 at 9 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 5.

NFL Week 5 Games

Indianapolis Colts @ Denver Broncos (TNF)

Colts +3.5 (-115) @ Broncos -3.5 (-105)

It’s a battle of two veteran quarterbacks on new teams as Matt Ryan and the Colts head to Denver to take on Russell Wilson and the Broncos in a pivotal AFC matchup. Neither has been particularly impressive thus far, but both are showing signs of improvement.

The loss of Javonte Williams (torn ACL) is a big blow to the Broncos, while Colts’ running back Jonathan Taylor (ankle) escaped a significant injury.

If he suits up this week, Indy could win this game outright.

New York Giants @ Green Bay Packers (Oct. 9, 9:30 a.m. ET - London)

Giants +7.5 (-110) @ Packers -7.5 (-110)

After hosting a thrilling matchup between the Saints and Vikings in Week 4, London will provide the backdrop for an intriguing NFC showdown between a pair of 3-1 teams.

New York certainly wasn’t expected to start this well, but Brian Daboll‘s squad has shown the ability to grind out low-scoring victories. I’d be interested in backing the Giants as underdogs of more than a touchdown in this spot, but we’ll have to wait for the status of Daniel Jones (ankle) and Tyrod Taylor (concussion) after both Giants quarterbacks got dinged up Sunday.

Pittsburgh Steelers @ Buffalo Bills (Oct. 9, 1 p.m. ET)

Steelers +14 (-110) @ Bills -14 (-110)

The Kenny Pickett era is officially underway in Pittsburgh after the rookie quarterback replaced Mitchell Trubisky in the second half of Sunday’s 24-20 home loss to the Jets. His first NFL action saw mixed results as he led a pair of touchdown drives but also threw three interceptions, including one on a last-second Hail Mary.

While Pittsburgh has always been a scrappy opponent under Mike Tomlin, they don’t have the firepower to keep pace with this high-octane Bills’ offense. This two-touchdown spread, the highest of the week and the season so far, is a lot of points to cover, though.

Houston Texans @ Jacksonville Jaguars

Texans +7 (-110) @ Jaguars -7 (-110)

Outside of his troubles holding onto the football Sunday in wet Philadelphia Sunday, Trevor Lawrence has taken a big step forward in Year 2 and this Jaguars squad looks like a contender under head coach Doug Pederson.

Meanwhile, Houston is still searching for its first win of the season but showed some fight on Sunday as they tried to climb out of a 27-7 halftime deficit against the Chargers. Davis Mills will have to play a clean game for the Texans to cover, let alone win.

Chicago Bears @ Minnesota Vikings

Bears +7 (-115) @ Vikings -7 (-105)

The Bears may be 2-2, but this offense is among the worst in the NFL. Through four games, Justin Fields has completed just 34 passes and has been sacked 16 times. It’s not all his fault, as Chicago hasn’t given him much of a supporting cast, but he is arguably the worst quarterback in the league right now.

It’s hard to imagine this Bears offense keeping pace with the Vikings on the road. I’d wait for this number to dip below seven, then buy back on Minnesota at home.

Detroit Lions @ New England Patriots

Lions +2.5 (-106) @ Patriots -2.5 (-114)

You would have been hard-pressed to sell me on a matchup between Bailey Zappe and Jared Goff before the season started, but this could be a wildly entertaining game. Detroit officially can’t stop anyone on defense after allowing 555 total yards to the Seahawks Sunday, but the Lions also scored 45 points without D’Andre Swift and Amon-Ra St. Brown in the lineup.

If those two guys are healthy this weekend, I’d back Detroit to win outright.

Seattle Seahawks @ New Orleans Saints

Seahawks +4.5 (-110) @ Saints -4.5 (-110)

Geno Smith has been better than advertised this season, and Rashaad Penny finally had his breakout game against the Lions. This will be a much tougher matchup for Seattle’s ground game, however, as the Saints’ defense excels at stopping the run.

New Orleans was desperately shorthanded on offense in London and still nearly beat a much better Minnesota team. If Alvin Kamara or Michael Thomas returns, the Saints should win and cover this number.

Miami Dolphins @ New York Jets

Dolphins -3.5 (-110) @ Jets +3.5 (-110)

The Dolphins will have a few extra days to prepare for this AFC East clash, which is probably a good thing for Miami as it gives Teddy Bridgewater more time to get ready for his first start of the season. Bridgewater was serviceable in relief of the injured Tua Tagovailoa (head/neck), and has plenty of experience as a starter.

I expect the Dolphins to still win and cover as road favorites, but it is a bit surprising to see this number above a key number. Zach Wilson led an impressive game-winning drive in his season debut, so I expect more people will want to back the Jets at home as the week goes on.

Atlanta Falcons @ Tampa Bay Buccaneers

Falcons +8 (-110) @ Buccaneers -8 (-110)

This is a get-right spot for the Buccaneers, who have lost back-to-back games. Still, Tampa Bay is tied for the NFC South division lead with Atlanta and should put some distance between themselves and the Falcons here.

Tom Brady hasn’t lost three straight games in his tenure with the Buccaneers, and I don’t see anything but a high-scoring win for the home team in this one.

Los Angeles Chargers @ Cleveland Browns

Chargers -3 (-105) @ Browns +3 (-115)

A pair of teams with preseason expectations and 2-2 records will meet Sunday in Cleveland. The injury-riddled Chargers looked back to full form in the first half of their 34-24 win over the Texans, but things got a little close for comfort late.

Meanwhile, the Browns fell to the Falcons in Atlanta last week as Jacoby Brissett again threw an interception late in the fourth quarter that ended Cleveland’s comeback hopes. I don’t really trust either of these teams, so this is a stay away from the spread on a key number.

Tennessee Titans @ Washington Commanders

Titans -2.5 (-114) @ Commanders +2.5 (-106)

The Titans are one of the more confusing teams in the league, but Ryan Tannehill and Derrick Henry have steadied the ship after an 0-2 start. After winning its season-opener, Washington has lost three straight and scored just 18 points over the last two weeks.

I could see the Commanders springing the upset here, but this number will get to three, so I’d hold off if you want to bet the Washington side.

San Francisco 49ers @ Carolina Panthers (Oct. 9, 4:05 p.m. ET)

49ers -4.5 (-108) @ Panthers +4.5 (-112)

If the Bears have the worst offense in the league, the Panthers are probably next on that list. Baker Mayfield had three more turnovers Sunday against Arizona and Carolina mustered just 220 total yards.

I can see this spread getting up to six or seven points in San Francisco’s favor, especially if the 49ers knock off the Rams on Monday Night Football. The time to buy in is now.

Philadelphia Eagles @ Arizona Cardinals

Eagles -5.5 (-110) @ Cardinals +5.5 (-110)

The Eagles are the last remaining undefeated team in football after knocking off the Jaguars Sunday in wet conditions to improve to 4-0. Philadelphia’s offense can beat you in a variety of ways, and Jalen Hurts is playing at an elite level.

Arizona (2-2) is still in the mix in the early-season NFC playoff conversation, but the Cardinals haven’t looked as good as their record may indicate. I’d be surprised if Philly’s unbeaten start ended here.

Dallas Cowboys @ Los Angeles Rams

Cowboys +5.5 (-105) @ Rams -5.5 (-115)

There’s a chance Dak Prescott (thumb) could return for the Cowboys, but I’m not sure Mike McCarthy needs to rush his starting quarterback into action after Cooper Rush led Dallas to another win in Week 4.

While the defending Super Bowl champion Rams will present a bigger challenge than Washington, I think Dallas could cover this number. Let’s see how LA looks on MNF before making a decision.

Cincinnati Bengals @ Baltimore Ravens (Sunday Night Football)

Bengals +3 (-102) @ Ravens -3 (-120)

The Bengals will have extra time to prep for their AFC North rival after getting back to .500 on Thursday night, while Baltimore lost another game in which they had a double-digit lead. Still, the Ravens have looked the better team through the first month of the season and will have a raucous home-field advantage.

Take the Ravens to get back on track and cover this field-goal spread as your NFL pick of the day.

Las Vegas Raiders @ Kansas City Chiefs (Monday Night Football)

Raiders +7.5 (-110) @ Chiefs -7.5 (-110)

The Raiders saved their season with a Week 4 win over the Broncos, and another victory over an AFC West rival would go a long way toward boosting Las Vegas’ playoff hopes. That won’t come easy as Patrick Mahomes and Kansas City lit up a previously staunch Buccaneers defense on Sunday Night Football.

With such a resounding win in primetime, this number feels a bit inflated, so I’d probably back the Raiders at a touchdown or more.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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