NFL Week 4 Odds | Opening NFL Moneyline, Spread, & Total Betting Lines

Posted: Jul 12, 2022Last updated: Aug 5, 2022

Week 4 of the 2022 NFL season serves up a Super Bowl 55 rematch on Sunday Night Football as the Tampa Bay Buccaneers will host the Kansas City Chiefs.

This week also marks the first International Series game of the year, as the Minnesota Vikings take on the New Orleans Saints at Tottenham Hotspur Stadium in London.

With plenty of other storylines to discuss, let’s look at the current Week 4 NFL odds and lines for the 2022 season.

NFL Week 4 Odds & Lines

Week 4 NFL odds are courtesy of Betway Sportsbook unless otherwise noted and are current as of Tuesday, July 12 at 4:30 p.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 4.

NFL Week 4 Games

Miami Dolphins @ Cincinnati Bengals (Thursday Night Football)

Dolphins +4 (-110) @ Bengals -4 (-110)

The top two quarterbacks selected in the 2020 NFL Draft will face off for the first time when Joe Burrow and the Bengals host Tua Tagovailoa and the Dolphins on Thursday Night Football.

These two teams last met in December 2020, with Tua leading Miami to a 19-7 home victory, but Burrow had already undergone season-ending knee surgery. Heading into Year 3, Burrow is certainly the more established quarterback, but I’m not ready to lay the points here.

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Minnesota Vikings @ New Orleans Saints (Oct. 2, 10:30 a.m. ET - London)

Vikings -1 (-110) @ Saints +1 (-110) 

The NFL’s first international contest comes in Week 4, when the Vikings and Saints do battle at Tottenham Hotspur Stadium in London. Both franchises are 2-0 all-time overseas, so something will have to give here.

It pains me to say it, but I’m trusting the Vikings to conquer the Saints in this one.

Buffalo Bills @ Baltimore Ravens (Oct. 2, 1 p.m. ET)

Bills -1 (-110) @ Ravens +1 (-110)

The two best quarterbacks from the 2018 NFL Draft class will also square off in Week 4 when Lamar Jackson and the Ravens host Josh Allen and the Bills.

This potential AFC postseason preview should be a highly entertaining game with plenty of offense on both sides, but it’s too early to pick a winner.

Washington Commanders @ Dallas Cowboys

Commanders +6 (-110) @ Cowboys -6 (-110)

The Cowboys swept the Commanders in 2021, outscoring Washington 83-34 across two meetings. Most of those points came in a 56-14 Dallas rout at AT&T Stadium.

Dak Prescott owns a resounding 9-1 record against Washington in his career and should be able to lead the Cowboys to a win of a touchdown or more.

Seattle Seahawks @ Detroit Lions

Seahawks +1 (-110) @ Lions -1 (-110)

If this matchup came later in the season, odds are it would be a battle for NFL Draft positioning, as neither team is expected to do much this season. This is a pure toss-up.

Cleveland Browns @ Atlanta Falcons

Browns N/A @ Falcons N/A

We still don’t have spreads on early-season Browns matchups because we aren’t sure when Deshaun Watson will be eligible to play. Still, whether it’s Watson or Jacoby Brissett, the Browns have a pretty good chance to take down the rebuilding Falcons.

Los Angeles Chargers @ Houston Texans

Chargers -8 (-110) @ Texans +8 (-110)

One of the major reasons the Chargers failed to make the playoffs last season was a shocking 41-29 defeat to the Houston Texans in Week 16. Rex Burkhead exploited Los Angeles’ league-worst run defense and Davis Mills played solid, mistake-free football.

The odds of the Chargers sleepwalking through another trip to Houston seem low after last year’s debacle, so you can take this spread with confidence.

Tennessee Titans @ Indianapolis Colts

Titans +3 (-110) @ Colts -3 (-110) 

The Titans swept the season series against the Colts last season and have won three straight over their AFC South rival overall, but Indianapolis is a home favorite here for a reason.

Matt Ryan brings a different dimension to this Colts’ offense, which could make the difference here. Still, I wouldn’t be shocked if this game was decided by a field goal, so this is a stay away for me.

Chicago Bears @ New York Giants

Bears +2.5 (-110) @ Giants -2.5 (-110) 

The Giants put on one of the most embarrassing performances in franchise history last season against the Bears, losing 29-3 in Week 17. New York registered -6 passing yards (no, that’s not a typo) and turned the ball over four times.

Big Blue should be better this year and both presumed starting quarterbacks sat out that contest, so I don’t feel comfortable betting either side here.

Jacksonville Jaguars @ Philadelphia Eagles

Jaguars +6.5 (-110) @ Eagles -6.5 (-110) 

Jaguars head coach Doug Pederson will be amped up for a return to Philadelphia, a place where he led the Eagles to a Super Bowl title, only to get fired three seasons later.

This feels like a big number for Philadelphia to cover, making it good spot to back the road underdog.

New York Jets @ Pittsburgh Steelers

Jets +3.5 (-110) @ Steelers -3.5 (-110) 

The Jets and the Steelers are the odds-on favorites to finish last in their respective divisions, so you may want to avoid putting your hard-earned dollars on either of these teams.

Arizona Cardinals @ Carolina Panthers (Oct. 2, 4:05 p.m. ET)

Cardinals -1.5 (-110) @ Panthers +1.5 (-110)

The Panthers’ final win of 2021 came in Week 10 against the Cardinals when Cam Newton made his Carolina return and plunged into the end zone on a trademark goal-line run. Things went downhill fast from there.

Things may be different this year with Baker Mayfield under center, while the Cardinals will still be without DeAndre Hopkins (suspension) in this one. This spread seems fishy.

New England Patriots @ Green Bay Packers

Patriots +5 (-110) @ Packers -5 (-110)

A matchup between the Packers and Patriots just doesn’t feel the same without Tom Brady opposing Aaron Rodgers, but Bill Belichick will still try his best to stymie the back-to-back NFL MVP.

Both of these teams should be a bit worse off than they were last year, and this is an odd spread. I’ll wait and see how each side starts the season.

Denver Broncos @ Las Vegas Raiders

Broncos PICK (-110) @ Raiders PICK (-110)

Russell Wilson will get his first taste of AFC West play when the Broncos visit the Raiders in Week 4. Las Vegas swept the season series last year, but both of these rosters look dramatically different than they did last season.

I think the Broncos are the better team moving forward, but I’ll take the Raiders to protect home turf as our NFL Pick of the Day.

Kansas City Chiefs @ Tampa Bay Buccaneers (Sunday Night Football)

Chiefs +2.5 (-110) @ Buccaneers -2.5 (-110)

The Kansas City Chiefs will make their first trip to Raymond James Stadium since losing to the Buccaneers in Super Bowl 55. Duels between Patrick Mahomes and Brady are always entertaining, so this will be a can’t-miss game on Sunday Night Football.

The Buccaneers may still be short on weapons at this point, so I’m backing the Chiefs to exact their long-awaited revenge in Tampa. Make this your NFL pick of the day.

Los Angeles Rams @ San Francisco 49ers (Monday Night Football)

Rams -1 (-110) @ 49ers +1 (-110)

Monday Night Football features a rematch of the NFC Championship Game, which the Rams won 20-17 at home to effectively end the Jimmy Garoppolo era in San Francisco.

Instead, second-year pro Trey Lance will lead the 49ers in this primetime contest against the defending Super Bowl champions. San Francisco had six straight against the Rams before that postseason meeting, so I’ll back Kyle Shanahan to once again get the better of Sean McVay.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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