NFL Week 4 Odds & Opening Lines

Last Updated: Jan 23, 2023

Week 4 of the 2022 NFL season serves up a Super Bowl 55 rematch on Sunday Night Football, as the Tampa Bay Buccaneers (2-1) will host the Kansas City Chiefs (2-1).

This week also marks the first International Series game of the year, as the Minnesota Vikings (2-1) take on the New Orleans Saints (1-2) at Tottenham Hotspur Stadium in London.

With plenty of other storylines to discuss as the calendar flips to October, let’s look at the current Week 4 NFL odds and lines for the 2022 season.

NFL Week 4 Odds & Lines

Week 4 NFL odds are courtesy of FanDuel Sportsbook unless otherwise noted and are current as of Monday, Sept. 26 at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 4.

NFL Week 4 Games

Miami Dolphins @ Cincinnati Bengals (Thursday Night Football)

Dolphins +3 (-115) @ Bengals -3 (-105)

The top two quarterbacks selected in the 2020 NFL Draft will face off for the first time when Joe Burrow and the Bengals host Tua Tagovailoa and the Dolphins on Thursday Night Football.

These two teams last met in December 2020, with Tua leading Miami to a 19-7 home victory, but Burrow had already undergone season-ending knee surgery. After leading his team to the Super Bowl last year, Burrow is certainly the more established quarterback, but Tua has had a more impressive start to the season.

The Dolphins are 3-0 and catching points on the road, which makes this line a little…fishy. I’d stay away at this number.

Minnesota Vikings @ New Orleans Saints (Oct. 2, 10:30 a.m. ET - London)

Vikings -2.5 (-114) @ Saints +2.5 (-106)

The NFL’s first international contest of the year arrives in Week 4, when the Vikings and Saints do battle at Tottenham Hotspur Stadium in London. Both franchises are 2-0 all-time overseas, so something will have to give here.

Neither teams were particularly convincing last week, but I trust the Saints to bounce back after a disappointing divisional loss.

Buffalo Bills @ Baltimore Ravens (Oct. 2, 1 p.m. ET)

Bills -3 (-110) @ Ravens +3 (-110)

The two best quarterbacks from the 2018 NFL Draft class will square off in Week 4 when Lamar Jackson and the Ravens host Josh Allen and the Bills. I’d expect Buffalo to bounce back after suffering its first loss of the season, but laying the points is tough with this spread on a key number.

This potential AFC postseason preview should be a highly entertaining game with plenty of offense on both sides.

Washington Commanders @ Dallas Cowboys

Commanders +3 (-118) @ Cowboys -3 (-104)

The Cowboys swept the Commanders in 2021, outscoring Washington 83-34 across two meetings. Most of those points came in a 56-14 Dallas rout at AT&T Stadium.

With Dak Prescott, who owns a resounding 9-1 record against Washington in his career, still sidelined, this should be a competitive game.

Seattle Seahawks @ Detroit Lions

Seahawks +6 (-110) @ Lions -6 (-110)

The lookahead line on this game from the summer had Detroit installed as a one-point favorite, but the perceptions of these teams have certainly changed since then.

The Lions should win this game, but I wouldn’t be shocked if Seattle sneaks in the number, especially if it gets to seven later in the week.

Cleveland Browns @ Atlanta Falcons

Browns -2.5 (-115) @ Falcons +2.5 (-105)

Two of the NFL’s leading rushers will meet up in Atlanta when Nick Chubb and the Browns visit Cordarrelle Patterson and the Falcons. Cleveland has a rest advantage in this one after knocking off the rival Steelers on Thursday night, however, I’m going to back to the well with the Falcons.

Los Angeles Chargers @ Houston Texans

Chargers -6.5 (-110) @ Texans +6.5 (-110)

One of the major reasons the Chargers failed to make the playoffs last season was a shocking 41-29 defeat to the Houston Texans in Week 16. Rex Burkhead exploited Los Angeles’ league-worst run defense and Davis Mills played solid, mistake-free football.

The odds of the Chargers sleepwalking through another trip to Houston seem low after last year’s debacle, so you can take this spread with confidence. Get in there now before it gets to seven or more points.

Tennessee Titans @ Indianapolis Colts

Titans +3 (-104) @ Colts -3 (-118)

The Titans swept the season series against the Colts last season and have won three straight over their AFC South rival overall, but Indianapolis is a home favorite after knocking off the Kansas City Chiefs last week.

Neither of these offenses has looked particularly effective over the first three weeks, so this is a stay away for me at this number. I’d consider buying the Titans at +3.5 or better, though.

Chicago Bears @ New York Giants

Bears +3 (-118) @ Giants -3 (-104)

The Giants put on one of the most embarrassing performances in franchise history last season against the Bears, losing 29-3 in Week 17. New York registered -6 passing yards (no, that’s not a typo) and turned the ball over four times.

It’s shocking that both of these teams will have at least a 2-1 record heading into this game, but Big Blue is the better bet here at home. Justin Fields has looked erratic, and as long as New York can stop the run, they should win this game by at least a field goal at home.

Jacksonville Jaguars @ Philadelphia Eagles

Jaguars +7 (-115) @ Eagles -7 (-105)

Jaguars head coach Doug Pederson will be amped up for a return to Philadelphia, a place where he led the Eagles to a Super Bowl title, only to get fired three seasons later.

As good as Philadelphia has looked to start the season, this feels like a big number to cover against a much improved Jacksonville squad.

New York Jets @ Pittsburgh Steelers

Jets +3.5 (-114) @ Steelers -3.5 (-106)

The Jets and the Steelers were the odds-on favorites to finish last in their respective divisions heading into the season, and not much has changed in that regard. We should see New York’s Zach Wilson get his first start of the year, while it looks like Pittsburgh will be sticking with Mitch Trubisky for the time being.

I’d lean towards taking the points with the Jets, but there are a lot of unknowns in this one.

Arizona Cardinals @ Carolina Panthers (Oct. 2, 4:05 p.m. ET)

Cardinals +1 (-112) @ Panthers -1 (-108)

The Panthers earned their first victory of the season on Sunday over the Saints, their first since defeating the Cardinals in Week 10 when Cam Newton made his Carolina return and plunged into the end zone on a trademark goal-line run.

Arizona has looked dreadful for the majority of the season so far, but they seem to play somewhat better away from home. I think the Cardinals should still be favored in this one, as they were over the summer on the lookahead line.

New England Patriots @ Green Bay Packers

Patriots +10 (-110) @ Packers -10 (-110)

A matchup between the Packers and Patriots just doesn’t feel the same without Tom Brady opposing Aaron Rodgers, but Bill Belichick will still try his best to stymie the back-to-back NFL MVP after he got the better of Brady last week.

This spread has gotten out of hand due to the uncertainty around New England quarterback Mac Jones (ankle), so I’ll be staying away until we know more later in the week. If the spread gets above 10, that could be a time to buy on the Patriots.

Denver Broncos @ Las Vegas Raiders

Broncos +1 (-110) @ Raiders -1 (-110)

Russell Wilson will get his first taste of AFC West play when the Broncos visit the Raiders in Week 4. Las Vegas swept its division rival last year, but both of these rosters look dramatically different than they did last season.

After starting 0-3, the Raiders will be desperate to get a win against a 2-1 Denver team that has looked far from impressive this season. It’s now or never for Las Vegas.

Kansas City Chiefs @ Tampa Bay Buccaneers (Sunday Night Football)

Chiefs -2.5 (-114) @ Buccaneers +2.5 (-106)

The Kansas City Chiefs will make their first trip to Raymond James Stadium since losing to the Buccaneers in Super Bowl 55. Duels between Patrick Mahomes and Tom Brady are always entertaining, so this will be a can’t-miss game on Sunday Night Football.

The Buccaneers will get Mike Evans back from suspension, but could still be short on weapons. After a tough loss, I’m backing the Chiefs to exact their long-awaited revenge in Tampa as my NFL pick of the day.

Los Angeles Rams @ San Francisco 49ers (Monday Night Football)

Rams +1 (-114) @ 49ers -1 (-106)

Monday Night Football features a rematch of last year’s NFC Championship Game, which the Rams won 20-17 at home to effectively end the Jimmy Garoppolo era in San Francisco. Or so we thought.

Garoppolo will get the chance to avenge that loss and redeem himself after a poor primetime performance on SNF in a Week 3 defeat in Denver. San Francisco had won six straight against the Rams before that postseason meeting, so I’ll back Kyle Shanahan to once again get the better of Sean McVay.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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