NFL Week 4 Odds

Frank AmmiranteSenior Sports Writer
Last Updated: Sep 26, 2023

The NFL schedule has been released, so we can take a look at the betting lines for each week, including Week 4.

This is a week with a full slate of games since there aren’t any teams on a bye. We can take advantage of opening lines since we’re likely to see odds shifts as we get closer to game time.

Here are the current Week 4 NFL odds and lines for the 2023 season.

NFL Week 4 Odds & Lines

Week 4 lines are courtesy of Caesars Sportsbook and are current as of Monday, Sept. 25, at 3 p.m. ET.

Keep tabs on all of our current NFL odds leading into NFL Week 4.

NFL Week 4 Games

Detroit Lions @ Green Bay Packers

Sept. 28, 8:15 p.m. ET (TNF)

  • Lions -2 (-110) @ Packers +2 (-110)

The Lions (2-1) take on the Packers (2-1) in a pivotal NFC North matchup.

Detroit is coming off an impressive 20-6 win over the Falcons. They could easily be 3-0 right now, as their only loss came in overtime vs the Seahawks.

Green Bay got a huge comeback win in their 18-17 victory against the Saints. Jordan Love continues to impress in his first year as the starter.

Having said that, the Lions have the better team on paper. They’re favored for a good reason here, so give me Detroit -2.

Atlanta Falcons @ Jacksonville Jaguars

Oct. 1, 9:30 a.m. ET (London)

  • Falcons +3 (+100) @ Jaguars -3 (-120)

This is a battle of two struggling quarterbacks, with Falcons’ signal-caller Desmond Ridder (5.29 yards per attempt in Week 3) going up against Jaguars’ passer Trevor Lawrence (6.98 yards per attempt in Week 3).

Look for Jacksonville to bounce back from their 37-17 loss to the Texans with a victory over the Falcons in London.

As poorly as Lawrence has played, he’s still a much better quarterback than Ridder, giving the Jags a significant edge in this one.

Minnesota Vikings @ Carolina Panthers

Oct. 1, 1 p.m. ET

  • Vikings -3.5 (-110) @ Panthers +3.5 (-110)

Here we have a matchup between two 0-3 teams, with the disappointing Vikings taking on the rebuilding Panthers.

Minnesota is coming off a close loss to the Chargers and is the much better team here. Andy Dalton will likely get another start for Carolina with Bryce Young still injured.

The Vikings have too much firepower on offense, which should make it difficult for the Panthers to keep pace in this one.

Miami Dolphins @ Buffalo Bills

Oct. 1, 1 p.m. ET

  • Dolphins +2.5 (+100) @ Bills -2.5 (-120)

The Dolphins are coming off a ridiculous 70-20 win over the Broncos, putting them at 3-0 heading into a statement game against the division-rival Bills (2-1).

Miami should get Jaylen Waddle (concussion) back for this game. They look like the best team in the AFC right now, with Tua Tagovailoa playing at an MVP level.

Look for the Dolphins to upset the Bills with a massive road win in our NFL bet of the day.

Baltimore Ravens @ Cleveland Browns

Oct. 1, 1 p.m. ET

  • Ravens +2.5 (-110) @ Browns -2.5 (-110)

The Ravens (2-1) head to Cleveland to take on the Browns (2-1) in a huge AFC North divisional game.

The key here is the Browns’ defense, which continues to play at a high level, limiting opposing quarterbacks to only 408 passing yards in three games.

Look for Myles Garrett and company to cause problems for Lamar Jackson in what should be a low-scoring affair.

Denver Broncos @ Chicago Bears

Oct. 1, 1 p.m. ET

  • Broncos -3.5 (-105) @ Bears +3.5 (-115)

Despite allowing 70 points in a 50-point loss to the Dolphins, the Broncos come in as road favorites in Chicago. That’s how bad the Bears have been this season.

Quarterback Justin Fields has been one of the worst in the NFL this year, giving Denver an edge, as Russell Wilson has been playing better this season compared to last.

The Broncos need to find a way to get promising rookie wideout Marvin Mims Jr. more involved. I think they’ll do that here in a much-needed win.

Cincinnati Bengals @ Tennessee Titans

Oct. 1, 1 p.m. ET

  • Bengals PK (-110) @ Titans PK (-110)

The Titans continue to struggle in pass defense, getting torched by Deshaun Watson for 289 yards last week.

This sets up as a nice bounce-back spot for the Bengals’ passing game.

Look for Cincinnati to get a much-needed win against the struggling Ryan Tannehill and Titans team that is trending downward.

Pittsburgh Steelers @ Houston Texans

Oct. 1, 1 p.m. ET

  • Steelers -3 (-110) @ Texans +3 (-110)

Texans’ rookie quarterback C.J. Stroud continues to impress, leading the team to an upset win over the Jaguars in Week 3.

Stroud gives Houston an edge at quarterback over Kenny Pickett and the Steelers. Add in home-field advantage, and you can see why the Texans look appealing as home underdogs.

Look for Houston to keep this one close and potentially win outright in another upset.

Washington Commanders @ Philadelphia Eagles

Oct. 1, 1 p.m. ET

  • Commanders +7 (-110) @ Eagles -7 (-110)

After an impressive 2-0 start, the Commanders crashed back to Earth with a 37-3 blowout loss to the Bills.

Sam Howell has performed well at times, but he’s also made several mistakes by forcing throws into coverage, resulting in interceptions.

In this one, it will be tough for the Commanders to keep pace with the Eagles. We get an appealing number of -7 instead of -7.5, making Philly look like a strong play.

Tampa Bay Buccaneers @ New Orleans Saints

Oct. 1, 1 p.m. ET

  • Buccaneers +3 (-115) @ Saints -3 (-105)

The Saints blew a lead in their loss to the Packers, putting them at 2-1 on the season, heading into an NFC South divisional matchup with the Buccaneers.

New Orleans’ quarterback Derek Carr suffered a shoulder injury in Week 3, putting Jameis Winston in as his replacement for the next couple of games.

The Saints will get back Alvin Kamara for this one, so there’s a strong supporting cast here that also includes Chris Olave and Michael Thomas. Look for New Orleans to bounce back with a win here.

Los Angeles Rams @ Indianapolis Colts

Oct. 1, 1 p.m. ET

  • Rams +1 (-115) @ Colts -1 (-105)

It’s great to see Rams quarterback Matthew Stafford back in top form this season.

He’ll look to help his team get a huge road win against the Colts, who are playing terrific football under new head coach Shane Steichen, coming off an upset victory over the Ravens.

Whether Anthony Richardson (concussion) is able to return or if Gardner Minshew is forced to play again, this has the makings of a close game. I’ll roll with the Rams as underdogs because of their edge at quarterback.

Las Vegas Raiders @ Los Angeles Chargers

Oct. 1, 4:05 p.m. ET

  • Raiders +5.5 (-110) @ Chargers -5.5 (-110)

The Chargers should be able to take care of business against the Raiders here, as Jimmy Garoppolo is currently in concussion protocol, which leaves either journeyman Brian Hoyer as the starter or rookie Aidan O’Connell.

I’d bet that head coach Josh McDaniels defers to the veteran Hoyer here, which gives the Chargers a massive edge at quarterback with Justin Herbert under center.

Los Angeles should be able to win by at least a touchdown in this one.

Arizona Cardinals @ San Francisco 49ers

Oct. 1, 4:25 p.m. ET

  • Cardinals +14 (-110) @ 49ers -14 (-110)

The Cardinals are coming off a major upset over the Cowboys. Head coach Jonathan Gannon has his team playing hard, as they’ve surprisingly held a lead in each of their three games this year.

But it will be tough for Joshua Dobbs and company to keep up with the best team in the NFL, the 49ers.

Don’t overreact to Arizona’s big win over Dallas; this is still a bottom-three team in the league. Look for a 49ers’ blowout here.

New England Patriots @ Dallas Cowboys

Oct. 1, 4:25 p.m. ET

  • Patriots +7 (-120) @ Cowboys -7 (+100)

In typical Cowboys fashion, they laid an egg on the road against a vastly inferior Cardinals team after starting the year with two blowout wins.

While New England has a tough defense and Mac Jones has played better this year, the Cowboys should be able to bounce back with a home win.

Look for Tony Pollard to carry the load in a convincing Dallas win here.

Kansas City Chiefs @ New York Jets

Oct. 1, 8:20 p.m. ET (SNF)

  • Chiefs -9.5 (-110) @ Jets +9.5 (-110)

Here we have a total mismatch with Patrick Mahomes and the Chiefs taking on Zach Wilson and the Jets.

Wilson has shown zero improvements since last year, establishing himself as one of the biggest busts in recent memory.

As good as the Jets’ defense is, I can’t see Wilson doing enough on offense to keep pace with Mahomes.

Seattle Seahawks @ New York Giants

Oct. 2, 8:15 p.m. ET (MNF)

  • Seahawks +1 (-110) @ Giants -1 (-110)

The Seahawks have done a nice job of bouncing back following their Week 1 blowout loss to the Rams, earning victories against the Lions and Panthers.

The Giants could easily be 0-3 right now, as their lone win came in a 20-0 comeback against the Cardinals.

Seattle is the better team on paper, and it’s unclear if Saquon Barkley will suit up for this game, so we’ll take the Seahawks as one-point underdogs.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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