NFL Week 17 Odds & Opening Lines

Posted: Dec 26, 2022Last updated: Jan 3, 2023

The penultimate week of the NFL season should provide plenty of drama as teams battle for playoff spots and seeding.

The Week 17 slate features seven divisional matchups and some intriguing primetime showdowns. Kicking off 2023 with a full day of NFL RedZone, capped off by an AFC North battle between the Ravens and Steelers on Sunday Night Football sounds like the perfect way to ring in the new year.

Here are the current Week 17 NFL odds and lines for the 2022 season.

Week 17 NFL Odds & Lines

Week 17 NFL odds are courtesy of Caesars Sportsbook unless otherwise noted and are current as of Monday, Dec. 26, at 10:30 a.m. ET. Be sure to keep tabs on all of our current NFL odds leading into NFL Week 17.

Week 17 NFL Games

Dallas Cowboys @ Tennessee Titans (Thursday Night Football)

Cowboys -9.5 (-110) @ Titans +9.5 (-110)

The final Thursday Night Football game of the season will see the reeling Titans host the Cowboys in a battle of two playoff teams from a season ago. Dallas has already clinched a postseason berth this season, while Tennessee desperately needs a win to keep pace with the Jaguars in the AFC South.

Unfortunately, Malik Willis has shown nothing in the passing game for the Titans, who will need a monster day from Derrick Henry just to keep this close.

Arizona Cardinals @ Atlanta Falcons (Jan. 1, 1 p.m. ET)

Cardinals +3.5 (-110) @ Falcons -3.5 (-110)

Two teams on lengthy losing streaks will meet up in Atlanta on Sunday when the Falcons (four straight) host the Cardinals (five straight). Arizona has played its best football of the season away from home and should keep this game competitive if Colt McCoy (concussion) is healthy enough to start.

Give me the points with the Cardinals in a game with 2023 NFL Draft implications.

Chicago Bears @ Detroit Lions

Bears +6 (-110) @ Lions -6 (-110)

I know the Bears have nothing to play for and the Lions need a win to stay in the NFC wild card mix, but this feels like a lot of points to lay with a team that won the first matchup with its division rival, 31-30.

However, Detroit has played its best football at Ford Field. I’d prefer to tease the Lions down to a pick than bet the spread at this number.

Jacksonville Jaguars @ Houston Texans

Jaguars -4 (-110) @ Texans +4 (-110)

Despite being in the running for the No. 1 overall pick, the Texans have played competitive football over the last three weeks. Houston has also dominated this rivalry, winning nine straight against the Jaguars, including an ugly 13-6 game in Jacksonville back in October.

It’s ugly, but I think the Texans could be on the right side.

Denver Broncos @ Kansas City Chiefs

Broncos +13.5 (-110) @ Chiefs -13.5 (-110)

These two teams met just three weeks ago in Denver, with the Chiefs racing out to a 27-0 lead before ultimately hanging on for a 34-28 victory.

Backing the Broncos after an embarrassing Christmas Day defeat to the Rams isn’t exactly appetizing, but the Chiefs aren’t great in these spots as double-digit favorites. I’d lean toward Denver, though I’d like plus-14 or better.

Miami Dolphins @ New England Patriots

Dolphins -1 (-110) @ Patriots +1 (-110)

This AFC East showdown has huge implications in the playoff picture, with both teams still fighting for a wild card spot. Miami has lost four straight after Tua Tagovailoa threw three fourth-quarter interceptions in a Christmas Day loss to the Packers.

And while I have my concerns about the Dolphins’ offense, it’s hard to trust Mac Jones and this New England unit at the moment, as well. I’d lean toward the home team with the better defense, but this feels like a toss-up.

Indianapolis Colts @ New York Giants

Colts +3 (-110) @ Giants -3 (-110)

This spread has flipped since the preseason opened, and it’s pretty easy to see why. The Giants are a win away from reaching the postseason for the first time since 2016, while the Colts are starting a third different quarterback in Nick Foles.

I don’t usually like backing Daniel Jones as a home favorite, but there’s a sizable coaching mismatch here and New York is probably the prudent play at three points or less.

New Orleans Saints @ Philadelphia Eagles

Saints +6.5 (-110) @ Eagles -6.5 (-110)

This New Year’s Day matchup is meaningful to both teams as the Eagles will look to wrap up the NFC East, while the Saints try to stay alive in the NFC South race.

As good as Gardner Minshew looked last week against the Cowboys, I wouldn’t be laying this many points with Philadelphia. Teasing the Eagles down makes some sense, though.

Cleveland Browns @ Washington Commanders

Browns +2.5 (-110) @ Commanders -2.5 (-110)

Despite back-to-back defeats, the Commanders are still holding on to the final wild card spot in the NFC. However, there’s now a quarterback controversy in Washington after Carson Wentz replaced a turnover-prone Taylor Heinicke late in last week’s loss to the 49ers.

Browns quarterback Deshaun Watson hasn’t played to his previous standards since taking over in Cleveland, so I would probably lean toward the Under (40.5) instead of picking a side.

Carolina Panthers @ Tampa Bay Buccaneers

Panthers +3 (-110) @ Buccaneers -3 (-110)

The Under (40) is probably a solid play in this NFC South showdown, as well, especially since Buccaneers Unders are hitting at a 73% clip this season.

Carolina wants to run the ball, which is tough against this Tampa Bay defensive front, and Tom Brady still can’t get this offense to fire consistently. The loss of Panthers corner Jaycee Horn (broken wrist) could prove pivotal.

If I had to pick a side, I’d lean toward the Buccaneers at home.

San Francisco 49ers @ Las Vegas Raiders (Jan. 1, 4:05 p.m. ET)

49ers -6 (-110) @ Raiders +6 (-110)

The former Battle of the Bay Area should be one of the weekend’s most intriguing matchups as Derek Carr and Davante Adams go up against the best defense in the NFL.

The Raiders have a habit of playing up and down to their opponents, so I wouldn’t be surprised if Las Vegas stays within this number at home.

New York Jets @ Seattle Seahawks

Jets PICK (-110) @ Seahawks PICK (-110)

The fate of two promising seasons will come down to one game as both teams’ playoff hopes lie in the balance thanks to recent losing streaks.

It looks like Mike White (ribs) will be cleared to quarterback the downtrodden Jets, but will Tyler Lockett (finger) return to give Geno Smith a much-needed deep threat?

There’s still some uncertainty here, but I’m expecting the Jets’ defense to make it a long day for their former quarterback.

Los Angeles Rams @ Los Angeles Chargers

Rams +7 (-110) @ Chargers -7 (-110)

The SoFi Stadium derby will take place on Sunday afternoon after originally being scheduled for Sunday Night Football. Baker Mayfield has given the Rams’ offense a significant lift and the Chargers may have nothing to play for if they win Monday night in Indianapolis.

Give me Los Angeles the Rams to cover this seven-point spread at home on the road.

Minnesota Vikings @ Green Bay Packers

Vikings +3 (-105) @ Packers -3 (-115)

The Vikings have already clinched the NFC North, but they still have an outside shot to pip Philadelphia for the NFC’s No. 1 seed, and damaging the Packers’ playoff hopes in the process would just be icing on the cake.

Green Bay’s defense came up big against Miami on Christmas Day, and I don’t like betting against Aaron Rodgers at Lambeau in the winter. Give me Green Bay, but only at -3 or better.

Pittsburgh Steelers @ Baltimore Ravens (Sunday Night Football)

Steelers +3.5 (-110) @ Ravens -3.5 (-110)

This should be fun.

There’s nothing quite like a physical AFC North battle in primetime. However, we still don’t know if Lamar Jackson (knee) will return after nearly a month on the sidelines.

That has me leaning toward the visitors, but I’d stay away for now.

Buffalo Bills @ Cincinnati Bengals (Monday Night Football)

Bills -1.5 (-110) @ Bengals +1.5 (-110)

The reigning AFC champion Bengals will host the Super Bowl favorite Bills in a potential preview of this year’s AFC Championship Game. Joe Burrow finally has an offensive line to protect him, which will come in handy against a Bills defense that can still rush the passer without Von Miller (knee).

This could go either way, but I can guarantee you won’t want to miss a second of the action.


John Arlia

Before joining The Game Day, John served as the National Writer for the United Soccer League, where he primarily covered the USL Championship out of the league’s headquarters in Tampa, FL. A devout soccer fan, John attended the last two men’s World Cups in Brazil and Russia and can’t wait for the 2026 edition to come to North America. Having also written for Sporting News Canada since getting his master’s from the Walter Cronkite School of Journalism at ASU, John has acquired a diverse sporting background, but considers football, golf, and soccer his three strong suits.

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