Louisville Odds & Best Bets

Lance PattonPromotions Creator & Editor
Last Updated: Aug 9, 2023

The only thing that’s a certainty for the Louisville Cardinals this year is they’re going to look a whole lot different.

Jeff Brohm – fresh off a trip to the Big Ten Championship at Purdue – takes over his alma mater and brings in a new quarterback who is the polar opposite of the former. The defensive line will need to replace 33.5 sacks.

Through the portal, they traded 1,000-yard receivers with Georgia State transfer Jamari Thrash in and Tyler Hudson out.

Even so, the Cardinals return 13 starters, added a ton through the portal, and have one of the easiest schedules of any Power 5 squadron.

Louisville Betting Odds

Keep track of the best Louisville Cardinals and other CFB odds for the college football season:

Louisville Futures Lines

Louisville Cardinals Preseason Lines

Louisville Cardinals odds used in this report are current as of Tuesday, Aug. 8, at noon ET at the sportsbook(s) cited.

Louisville: Win National Championship (+50000)

BetRivers Sportsbook

I wouldn’t bet this at (+50000) on BetRivers, so I’m not touching it at the far lower price on other sportsbook operators.

It’d take a level of craziness we’ve never seen in College Football for Louisville to win it all. A completely revamped system with a first-year head coach and a far less athletic – but better passer – at quarterback.

And although Louisiville’s defense was the best it’s been in a decade last season, it lost two all-ACC defensive ends and depth at the position.

Brohm may end up building something special at his alma mater, but it won’t be this year.

Louisville: Win ACC (+1200)

DraftKings Sportsbook

The more I look at this bet, the more I don’t completely hate it.

After all, the Cardinals avoid Clemson, North Carolina, and Florida State in ACC play – the only three teams ahead of them in the ACC CFB odds. I believe Brohm is a fantastic coach and he’s been impressed with the depth and athleticism of both sides of the ball.

Even so, Louisville has plenty of question marks including replacing Malik Cunningham and two stud pass rushers.

Brohm is also expected to completely revamp the offensive scheme. He has never had a team average of over 152 rushing yards per game; Louisville has rushed for over 200 per game in four straight seasons.

Personally, I’m not quite ready to back them to beat a potential juggernaut in Clemson or a breakout Florida State team, but at this price, I wouldn’t knock you if you did.

Louisville Best Prop Bets

Louisville: Over 8 Wins (-110)

WAGER: 1 Unit @ Caesars Sportsbook

In a vacuum, I wouldn’t recommend betting win total Overs on units with a first-year head coach who is rebuilding an entire offensive scheme – albeit to the degree he no doubt would like to.

This situation is different for a couple of different reasons.

Brohm brought in a guy he’s worked with before – and seemingly trusts – at quarterback with Jack Plummer. He was able to retain several key pieces on both sides of the ball.

And he brought in capable players through the transfer portal, including seven offensive linemen, to bolster a unit that must be better in pass protection without Cunningham’s legs to bail them out.

Notre Dame and Kentucky in the non-conference isn’t exactly a dream draw, but every other game on the schedule – and including those two – is winnable. I’ll bite on Over 8 wins with the revamped Cardinals.

Bet on Louisville at the Top Sportsbooks

Sports betting is coming soon to Kentucky, so check out the best sportsbooks in Kentucky:


Lance Patton

Lance Patton is the Promotions Creator & Editor for The Game Day and also creates content for the NFL, college football, and college basketball. Before joining The Game Day, Lance did freelance work for a variety of sports betting websites as well as covering the Iowa Hawkeyes for FanSided.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

$1,500 No Sweat Bet + NBA SGP Token

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $150 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.