After a 2-2 result in Week 4, we’re looking for a better week this time around as we dive into Week 5 predictions of the 2025 NFL season.
We’ve got some interesting matchups for Week 5, including Broncos vs Eagles and Commanders vs Chargers.
So, without further ado, let’s get right into my Week 5 predictions for the 2025 NFL season.
Odds are courtesy of DraftKings Sportsbook as of October 2 at 11 a.m. ET.
NFL Week 5 Best Bet
Broncos (+3.5) at Eagles (-105)
DraftKings Sportsbook • WAGER: 1 Unit
The Broncos are currently 2-2, but they could easily be 4-0 right now. Remember, this team lost close games against the Chargers (23-20) and Colts (29-28).
Up next is a date with the defending Super Bowl champions, but this Eagles side looks like a shell of their former selves. Despite the 4-0 record, Philadelphia could easily be 1-3. They had a comeback win vs the Rams and benefited from costly turnovers against the Cowboys and Chiefs.
The Eagles offense is dysfunctional right now, which is bad news against a tough Broncos defense. I like getting past the key number of 3 here, as we win even if Denver loses by a field goal.
NFL Week 5 ATS Best Bets
Chargers (-2.5) vs Commanders (-115)
DraftKings Sportsbook • WAGER: 1 Unit
The Chargers are coming off a disappointing loss against the Giants, but this is a bounce-back spot against an undermanned Commanders offense.
While Jayden Daniels is expected to return for this game, top wide receiver Terry McLaurin is out, while Deebo Samuel is banged up.
That puts Daniels in a tough position against a Chargers defense that ranks 4th in EPA against the pass.
On top of that, we just saw the Commanders get shredded by Michael Penix Jr. and company. That’s bad news against Justin Herbert, who continues to play at an MVP level this season.
NFL Week 5 Over/Under Best Bets
Cowboys @ Jets Over 47.5 Points (-115)
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Here we have a projected shootout between two vulnerable defenses. Both the Cowboys (32nd) and Jets (28th) rank are among the worst teams in pass EPA.
We just saw Dak Prescott have success against an elite Packers defense, so there’s no reason to be too concerned in a much better matchup.
While Justin Fields has his flaws, this is a spot where he can hit his ceiling.
This looks like one of the highest-scoring games on the slate, given the state of these two defenses right now.
NFL Week 5 Moneyline Best Bets
Giants (+102) at Saints
DraftKings Sportsbook • WAGER: 1 Unit
The Giants were impressive in Jaxson Dart’s debut, pulling off the upset against an undefeated Chargers team.
While Malik Nabers is out for the season, Dart’s mobility should keep this offense afloat, especially with the emergence of Cam Skattebo in this backfield.
This pass rush is also starting to cause issues for opponents, as we saw for Herbert last week.
That’s bad news for Spencer Rattler and company, so give me the Giants as short underdogs here.
