We’re set for another week of NFL action in the 2025 season. There’s been no shortage of surprises so far this year, including the undefeated Colts with Daniel Jones playing like an MVP.
We’ve got some intriguing matchups for Week 4, including Colts vs Rams and Ravens vs Chiefs.
So, without further ado, let’s get right into my Week 4 predictions for the 2025 NFL season.
Odds are courtesy of DraftKings Sportsbook as of September 25 at 3 p.m. ET.
NFL Week 4 Best Bet
Lions (-10) vs Browns (-105)
DraftKings Sportsbook • WAGER: 1 Unit
The Lions are coming off a statement win against the Ravens on Monday Night Football. It’s clear that this offense can still function at a high level, even without a stud playcaller like Ben Johnson.
While the Browns shockingly upset the Packers last week behind their elite defense, this feels like a spot where they’ll be overmatched.
We saw Detroit sack Lamar Jackson seven times in Week 3, which makes me think Joe Flacco is going to be a sitting duck in the pocket in this matchup.
It’s hard to see how the Browns are able to keep pace with this high-octane Lions offense, so bet on Detroit to win by more than 10 points in this spot.
NFL Week 4 ATS Best Bets
Ravens (-2.5) @ Chiefs (-120)
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The Ravens are road favorites against the Chiefs here. While it’s always tempting to take Patrick Mahomes as a home underdog, this feels like a spot where they’re overmatched.
Even with Xavier Worthy likely to return, this is still an undermanned offense that is badly missing Rashee Rice.
Meanwhile, the Ravens have one of the best offenses in the NFL. I can’t see the Chiefs slowing them down enough to keep pace here.
With that in mind, we’ll take Baltimore to win by at least a field goal in this spot.
NFL Week 4 Over/Under Best Bets
Bears @ Raiders Over 47.5 Points (-115)
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The Bears offense came alive in a blowout win vs the Cowboys last week. Ben Johnson got into his bag of tricks and finally got the rookies more involved, including a 100-yard game from Luther Burden.
I’m betting that Chicago will build on that momentum, keeping it going against a Raiders defense that just got shredded by Marcus Mariota.
We’re getting below the key number of 48 on this Over, which means that we’ll win with a 27-21 result, which is a pretty common scoreline.
Look for another big game from Caleb Williams in this one.
NFL Week 4 Moneyline Best Bets
Falcons (+105) vs Commanders
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The Falcons were embarrassed in a road loss against the Panthers last week, which was a result that seemingly came out of nowhere.
But this feels like a bounce-back spot against a Commanders offense that is likely forced to play with Marcus Mariota once again.
Even though Mariota has performed well in this Kliff Kingsbury offense, I can’t pass up fading a backup quarterback as a road favorite.
Look for the Falcons to get back in the winning column here.
