It’s time for Week 4 of the 2025 NFL season, so let’s dive in with some of my favorite parlay bets.
On this page, you’ll find my best parlay, longshot parlay, and Same Game Parlay for Week 4.
The goal is to use my best parlay to cover any potential losses from my longshot and SGP. With that in mind, let’s look closer at the best parlay bets for Week 4.
Best NFL Week 4 Parlay
All NFL gameday odds are current as of Thursday, Sept. 25, at 10 a.m. from DraftKings Sportsbook.
Week 4 Top Parlay (+271)
DraftKings Sportsbook • WAGER: 0.5 Units
- Giants +6 (-110) vs Chargers
- Eagles/Buccaneers Under 43.5 (-105)
The top parlay starts with the Giants as home underdogs against the Chargers.
Even though this is a matchup between a winless and undefeated team, I’m riding with the G-Men to cover the spread in a letdown spot for the Chargers.
The key for me is the switch at quarterback, with first-round rookie Jaxson Dart making his NFL debut. This is a dual-threat gunslinger who can inject life into a lethargic offense. Don’t be surprised if Dart leads the Giants to an upset here.
I’ll finish it off with the Under in Eagles vs Buccaneers.
The Bucs are dealing with injuries on their offensive line, which could make it difficult to keep a stacked Eagles’ front-seven at bay.
I like that we’re getting above the key number of 43 here, which means that we win in a 23-20 result.
Target these two plays in our NFL bet of the day.
Longshot NFL Week 4 Parlay
Week 4 Longshot Parlay (+300)
DraftKings Sportsbook • WAGER: 0.5 Units
- Falcons ML (+105) vs Commanders
- Bears ML (-105) at Raiders
The longshot parlay starts off with the Falcons to upset the Commanders.
Atlanta is coming off a dreadful performance against the Panthers, where they were shut out in a blowout loss. Now at home, I like the Falcons to bounce back vs the Commanders.
We’re likely to see Marcus Mariota under center for Washington, as the team continues to take a cautious approach with Jayden Daniels.
Bet on an improved Falcons’ pass rush being the difference in this matchup.
I’ll finish it off with the Bears to get a road win against the Raiders.
Ben Johnson’s offense was firing on all cylinders in a victory over the Cowboys last week. I’m expecting that to continue vs a Raiders defense that just got picked apart by Mariota.
It also helps that the Raiders offensive line has been among the worst in the NFL so far, as promising rookie Ashton Jeanty has struggled to find running lanes.
Parlay these two underdogs in our longshot parlay of the day.
NFL Week 4 Same Game Parlay
Colts vs Rams Same Game Parlay (+172)
DraftKings Sportsbook • WAGER: 1 Unit
- Rams ML (-192)
- Colts/Rams Over 49.5 (-115)
The Same Game Parlay heads to Los Angeles in a potential shootout between the Colts and Rams.
Daniel Jones has been the biggest surprises of the NFL season, playing like an MVP candidate during the Colts’ 3-0 start.
But this is a tough test against an imposing Rams pass rush led by Jared Verse. While I still think the Colts will do enough on offense to push this over the total, I like the Rams to win at home.
The Colts have scored 33, 29, and 41 points this season, so this has the makings of a track meet. Bet on Stafford to lead the way in a win over Indianapolis in a high-scoring affair.
The Rams are the better team that could easily be 3-0 right now after that blown lead vs the Eagles in Week 3.
