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NFL Parlays Week 1

Frank AmmiranteSenior Sports Writer
@FAmmiranteTFJ
Last Updated: Sep 5, 2025

It’s finally time to take a look at the top Week 1 NFL parlays. The first week of the season is a great opportunity to get ahead of the market on undervalued teams.

In this article, you’ll find the best football parlay bet along with a longshot and Same Game Parlay for Week 1.

Let’s dive in to discuss the top parlay picks this week.

Best NFL Week 1 Parlay

All NFL gameday odds are current as of Friday, Sept. 5 at 12 p.m. ET from DraftKings Sportsbook.

Week 1 Top Parlay (-119)

DraftKings Sportsbook • WAGER: 1 Unit

  • Dolphins/Colts Under 47.5 Points (-120)
  • Texans/Rams Under 43.5 Points (-115)

The Week 1 top parlay starts off with the Dolphins and Colts to go Under 47.5 points.

This is a bet against the Colts offense. While I think that Daniel Jones can perform better with Shane Steichen’s play-calling, the fact is that he’s been one of the worst quarterbacks in the NFL in the last two seasons. Add in the fact that the Dolphins offense significantly last year, and you can see why I think that 47.5 points feels like too high of a bar.

The next pick is on the Texans vs Rams to stay Under 43.5 points.

Houston has one of the best defenses in the NFL. Adding C.J. Gardner-Johnson makes this one of the best secondaries in the NFL. With that in mind, we could see Matthew Stafford has some challenges in this game, especially while under duress from this vaunted pass rush led by Will Anderson Jr.

Look for each of these favorites to get it done in our top NFL bet of the day.

Longshot NFL Week 1 Parlay

Week 1 Longshot Parlay (+1082)

DraftKings Sportsbook • WAGER: 0.25 Units

  • Bryce Young 250+ Pass Yds (+204)
  • Ashton Jeanty 100+ Rush Yds (+289)

The longshot parlay starts with Bryce Young to throw for 250+ passing yards.

I’m going with the alternate line because this could be a shootout against a vulnerable Jaguars pass defense. With Tetairoa McMillan on the team, Young now has a legitimate No. 1 option. There’s a reasonable chance that this does wonders for this passing game.

I’ll add Ashton Jeanty to run for 100+ yards.

This is a generational talent on par with other elite running back prospects like Saquon Barkley and Bijan Robinson. I’m betting that Jeanty is going to be the focal point of the Raiders offense. I can see Vegas pulling off the upset in this game as well, which bodes well for Jeanty’s usage.

NFL Week 1 Same Game Parlay

San Francisco 49ers vs Seattle Seahawks Same Game Parlay (+330)

DraftKings Sportsbook • WAGER: 0.5 Units

  • Brock Purdy 250+ Pass Yds (+108)
  • Jaxon Smith-Njigba 70+ Rec Yds (+121)

The Week 1 Same Game Parlay focuses on the 49ers vs Seahawks.

I’ll start with Brock Purdy to rack up 250+ passing yards. With Christian McCaffrey banged up with a calf injury, we could see Purdy forced to air it out at a higher rate.

I’ll add Jaxon Smith-Njigba to get 70+ receiving yards. Expect JSN to take a major leap now that he’s the focal point of the Seahawks’ passing game. We’re getting +121 odds at a firmly attainable bar at 70+ yards.

Ride with these two alternate lines for a reasonable +330 payout.

Author

Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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