Colts vs Titans Predictions & Odds

Last Updated: Oct 23, 2022

The Colts won a thriller in Week 6, scoring a game-winning touchdown with less than a minute to go to avenge their previous loss to the Jaguars earlier in the season.

Will they be able to do the same against the rested Titans in Week 7? The lead in the AFC South is up for grabs in this all-important mid-season matchup.

Continue reading my Indianapolis vs Tennessee best bets and predictions to see how I have this one going.

Colts vs Titans Odds

As of Monday morning, the Colts are slight road underdogs against the Titans. Seeing as how Tennessee won its last matchup with Indianapolis in Week 4 and is coming off of a bye week here, I’m surprised that the Titans aren’t picked by 4.5 or 5 points.

Take a look at the best Colts odds and Titans odds for the 2022 NFL season.

Colts vs Titans Implied Totals

Titans 22.75, Colts 19.75

Oddsmakers have the Titans winning a low-scoring game, with both teams expected to record around 20 points.

Colts vs Titans Pick of the Day

Read more on this Colts vs Titans bet below.

Colts vs Titans Prediction

Titans 28, Colts 24

This is a prime spot for Derrick Henry and the Titans to take control of the AFC South. The Colts caught up last week with their win over the Jags, and if Indianapolis wins here, they would take sole possession of the top spot.

The Colts have struggled against the run so far this season and gave up 243 yards on the ground this past week against Jacksonville. Henry’s best game of the season came in Week 4 against Indy, so he should have no issues carving them up for 100-plus yards and a score.

At the same time, Tennessee bettors should take note of Indy’s improved passing game. The Titans’ defense ranks dead-last in passing yards allowed and 31st in touchdowns, and Matt Ryan just went for 389 yards and three touchdowns against the Jaguars.

The weaknesses of each defense will help drive the total up into the low 50s, and the Titans will emerge victorious in what is a must-win game for both teams.

Colts vs Titans Bet Tips

Here are some Colts vs Titans betting trends to consider before placing your bets:

  • Tennessee is 3-2 against the spread this season; Indianapolis is 3-3.
  • Overs are a combined 3-8 for these teams this year. Colts’ Overs are 1-5.
  • The Titans have won four straight against the Colts and five of their last six.

Colts vs Titans Best Bets

Titans -3 (+100) at Caesars Sportsbook

The Tennessee moneyline doesn’t present the best value at (-160) odds, but we can get plus-money (+100) on them against the spread. I like the Titans to rely on their rushing game and cover in Week 7, and I would bet them up to -3.5.

Before placing this bet, get the best Titans promo codes.

Over 42.5 Points (-110) at Caesars

The Titans can’t defend against the Colts’ passing game, and Indianapolis will struggle to contain Henry on the ground. I would bet the Over up to 44.5 points.

Before placing this bet, get the best Colts promo codes.


Garrett Chorpenning

Garrett Chorpenning is the Lead NBA Editor for The Game Day. His previous work includes covering the LA Clippers for Sports Illustrated and FanSided. He graduated from Ball State University in 2021.

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