Chiefs vs Colts Predictions

Last Updated: Sep 21, 2022

The Indianapolis Colts and Kansas City Chiefs entered the season as likely AFC contenders, but so far, they’ve landed on opposite sides of the coin.

The Chiefs have gone 2-0 with wins over the Cardinals and Chargers. The Colts, surprisingly, are 0-1-1 after tying the Texans and getting blanked by the Jaguars, 24-0.

Will the Colts finally rebound against the Chiefs? Find out in our Kansas City vs Indianapolis best bets and predictions.

Chiefs vs Colts Odds

Although the Colts are the home team in this matchup, they’re priced correctly as a 6.5-point underdog. Indianapolis has yet to prove that it can hang with a team like the Chiefs.

Take a look at the best Chiefs odds and Colts odds for the 2022 NFL season.

Chiefs vs Colts Implied Totals

Chiefs 27.5, Colts 21

Oddsmakers have the Chiefs winning a high-scoring game by about a touchdown on the road.

Chiefs vs Colts Pick of the Day

Read more on this Chiefs vs Colts bet below.

Chiefs vs Colts Prediction

Chiefs 34, Colts 14

The Colts’ offense has been rendered useless against two relatively weak defenses, which doesn’t bode well for their chances of defeating one of the top offensive teams in the NFL. Matt Ryan has thrown just one touchdown to his four interceptions, and Jonathan Taylor only saw nine carries in their Week 2 loss to Jacksonville.

Star wideout Michael Pittman Jr. wasn’t available against the Jaguars, but it’s hard to imagine that the end result would have been much different had he played.

The Chiefs, on the other hand, have looked strong behind the steady hand of Patrick Mahomes, who’s thrown seven touchdowns without a single interception. He should have no issues leading his team to a relatively easy victory on the road in Indianapolis.

Chiefs vs Colts Bet Tips

After opening as 2.5-point favorites, the line has shifted dramatically in Kansas City’s favor. The Colts have not lived up to expectations thus far, which has seen them drop to nearly a touchdown underdog at home in Week 3.

Here are some additional Chiefs vs Colts betting trends to consider:

  • The Chiefs are 1-1 against the spread this season.
  • The Colts are 0-2 against the spread.
  • Both Colts games have gone Under, while the Chiefs have split on totals.

Chiefs vs Colts Best Bets

Chiefs -6.5 (-115) at FanDuel Sportsbook

WAGER: 1 Unit

Don’t overthink this one — back the Chiefs at (-115) odds.

They’ve looked the part of a true Super Bowl contender in the early part of the season, and until the Colts can prove that they’re more than a basement-dweller, there’s no reason to think that they’ll be able to compete with Kansas City.

Before placing this bet, get the best Chiefs promo codes.

Under 48.5 Total Points (-110) at FanDuel

WAGER: 1 Unit

The Chiefs and their second-place offense will do their job to score in this contest, but it’s hard to rely on a Colts team that’s averaging a league-worst 10 points per game. I have this one going just Under the projected total.

Before placing this bet, get the best Colts promo codes.


Garrett Chorpenning

Garrett Chorpenning is the Lead NBA Editor for The Game Day. His previous work includes covering the LA Clippers for Sports Illustrated and FanSided. He graduated from Ball State University in 2021.

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