Seahawks vs Cardinals Predictions & Odds

Last Updated: Dec 18, 2022

The Seahawks (5-3) continue their surprising season with a visit to the division rival Cardinals (3-5), which they hold a two-game advantage over in the NFC West.

Seattle comes off its third straight win, a 27-13 victory over the Giants in Week 8. Arizona dropped its third game in the last four on Sunday, falling to the Vikings by a 34-26 score on the road.

Let’s take a closer look at our Seattle vs Arizona best bets, predictions, and betting tips for this Week 9 clash.

Seahawks vs Cardinals Odds

The Cardinals -2 line as of Tuesday afternoon on Caesars Sportsbook is at least somewhat of a surprise considering the disparity in the team’s records, and the fact Arizona was dominated by Seattle, 19-9, at Lumen Field back in Week 6.

The total of 50.5 points is a bit more expected, as each team has its fair share of explosive players on offense.

Take a look at the best Seahawks odds and Cardinals odds for the 2022 NFL season.

All odds are current as of noon ET, on Tuesday, Nov. 1, at Caesars Sportsbook.

Seahawks vs Cardinals Implied Totals

Cardinals 26.25, Seahawks 24.25

Seattle’s defense has particularly played well recently, but oddsmakers clearly see DeAndre Hopkins, who has a 22-262-1 line through his first two games, as a major difference maker for Arizona’s offense.

Additionally, the possibility that James Conner (ribs) returns for the home team could also be factored into the thinking of an elevated total.

Seahawks vs Cardinals Pick of the Day

Read more on this Seahawks vs Cardinals bet below.

Seahawks vs Cardinals Prediction

Cardinals 24, Seahawks 21

As expected, Hopkins’ availability has paid immediate dividends for the Cardinals, even with the team down both Marquise Brown (IR-foot) and Conner for each of the star wideout’s first two games. Arizona has scored a combined 68 points in those contests, although that has only translated into one victory.

Nevertheless, it’s clear Kyler Murray, as well as he worked with Brown when he was available, is at his best when Hopkins is at his disposal.

That should lead to just enough firepower for Arizona to prevail in a close matchup, with the possible availability of Conner naturally a bonus if it comes to pass. However, Eno Benjamin, who had 128 total yards in the first meeting between the teams, makes for a fine fill-in if called on again, even with Seattle showing significant improvement against the run over the last three games (91.7 RYPG allowed).

The Seahawks’ defense is still much stingier at home, however, giving up the fourth-most rushing yards per road game (155.5).

On the other side, the Cardinals have proven highly adept at holding top receivers below their usual levels of production all season, with fourth-year standout corner Byron Murphy and second-year man Marco Wilson each stepping up their play throughout the campaign.

The duo helped limit DK Metcalf and Tyler Lockett to four receptions for 51 yards on the road in the Week 6 encounter, which helped lead to the Seahawks’ second-lowest point total of the season.

Factoring in that Arizona generally does a good job limiting ground attacks, as well, even though they did give up some yardage to Dalvin Cook and Alexander Mattison in Week 8 but are allowing a modest 110.1 rushing yards per game.

With that, Kenneth Walker, who had a game-long 34-yard run against Arizona in Week 6 but gained just 63 yards on his other 20 carries, could have a difficult time producing as he has in a couple of other stellar starts this season.

As is typically the case with both teams, this will be a close game the home team will find a way to pull out late to get back to .500.

Seahawks vs Cardinals Bet Tips

Here are some Seahawks vs Cardinals betting trends to consider before placing your bets:

  • The Seahawks are 5-3 against the spread this season, including 2-2 as an away team.
  • The Cardinals are 4-4 against the spread this season, including 2-2 as a home team.
  • Seattle is 1-1 ATS in NFC West matchups thus far and Arizona is 0-2 against the number in that same split.
  • Kliff Kingsbury is 3-4 straight up against the Seahawks since becoming head coach in 2019, with no loss coming by less than seven points and the average margin of defeat checking in at 10.5 points.
  • The Over is a combined 7-8-1 in both teams’ games this season.

Seahawks vs Cardinals Best Bets

Cardinals -2 (-110)

The addition of Hopkins to the mix is already making a significant difference for Murray’s performance, and neither he nor Conner were available for Arizona’s 10-point loss in Week 6. The Cards are home and desperate for a win, and I see them pulling it out here by a narrow margin.

Thinking about betting the other side, check out the best Seahawks promo codes.

Cardinals Moneyline & Under 50.5 Points (+244)

Building on the belief of a close Cardinals win, I like the idea of combining the moneyline wager with the Under for a great price on a same-game parlay. Both defenses are talented, and the second game of the season against a divisional opponent can always lean toward the Under.

Moreover, even with the addition of Hopkins and the possible return of Conner, these two teams still have plenty of room to improve on the combined 28 points scored in their first meeting and have the Under still hit.

Before placing this bet, get the best Cardinals promo codes.

Seahawks vs Cardinals Props

Check out the best Seahawks vs Cardinals player prop bets this week with our props comparison tool. Click on the Seattle vs Arizona game below to see all of its prop bets.


Juan Carlos Blanco

Juan Carlos Blanco has been playing fantasy sports since 1997 and actively writing about the fantasy sports and sports betting industries since 2015 for multiple websites. He has covered a wide variety of professional sports leagues, including the NFL, MLB, NBA, CFL, Arena Football League, Alliance of American Football, XFL, NPB and KBO. He was the recipient of the FSWA's 2016 Newcomer of the Year award for his work with RotoWire.

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