49ers vs Texans Predictions | Best Bets & Odds

Frank AmmiranteFantasy Sports & Betting Writer
Posted: Aug 23, 2022Last updated: Aug 23, 2022

It’s the final week of the preseason, and it’s such an exciting time because it means that we’re so close to the start of the NFL season. It’ll be interesting to see if we get a glimpse of more starters this time around.

We’ve got the 49ers and Texans in this matchup, which raises a few questions. Will we see some Trey Lance? Can Davis Mills continue to flash more upside by connecting with young wideout Nico Collins?

Let’s dive in to explore the best bets for this San Francisco vs Houston matchup.

49ers vs Texans Odds

Both of these teams have won each of their preseason games. The 49ers have a much better roster, so it’s no surprise that they come in as three-point road favorites, according to our NFL odds. The total looks like a strong number, given the low-scoring nature of the preseason.

49ers vs Texans Implied Score

49ers 22.25, Texans 19.25

Bookmakers suggest that we’ll see a close 49ers road win in this Week 3 matchup. It’s also one of the higher totals on the slate, indicating that they project a higher-scoring game by preseason standards.

49ers vs Texans Pick of the Day

Read more about the best bets for the 49ers vs Texans below.

49ers vs Texans Matchup

Lance did not suit up for Week 2 of the preseason. This makes it likely that he’ll see some action here, putting the 49ers in a better position to win the game.

Reports indicate that Houston intends to play its starters for a larger portion of this game. There’s a better chance that we see more of their marquee players than San Francisco, considering that there’s more at stake for the preseason for the Texans.

49ers vs Texans Prediction

Texans 23, 49ers 20

Betting on the preseason is a volatile experience because it’s hard to determine which players are suiting up and how long they’ll be on the field. With the report stating that Houston intends to play more of its first-team players, it’s a good idea to ride the home underdog in this spot.

The Texans are a rebuilding team with several young players who need to get reps, including Mills, Collins Dameon Pierce, and more. It’s easier to put faith in them in this spot, especially since you’re getting them as underdogs.

While Lance should see more reps here, it’s unlikely that it’ll be for long - especially considering that he’s locked in as the starting quarterback in San Francisco.

Look for Houston to edge out the 49ers in this final week of the preseason.

49ers vs Texans Bet Tips

Here are a few San Francisco vs Houston bet tips to consider:

  • The Texans will play their starters
  • Both teams are 1-1 to the Over/Under so far this preseason

49ers vs Texans Best Bets

Texans +3 (-110) at Caesars Sportsbook

I generally lean toward underdogs in the preseason because of how unpredictable it can be. I like it even more here because of the confirmation that we’ll see more of the Texans’ starters.

Houston has more to lose in this game, so we’ll ride with the Texans in our NFL pick of the day.

Over 41.5 Total Points (-110) at Caesars Sportsbook

In Week 1, the Over went 11-5 against this number. However, we saw more low-scoring games in Week 2, as the Under bounced back for an 11-5 record. At the same time, since we’re likely to see more starters in this game, it’s safer to go on the side of the Over.

There’s a reason why this game has one of the higher totals on the slate, so we’ll bet on 42 or more points in this spot.


Frank Ammirante

Before joining The Game Day, Frank spent three years in the fantasy sports and betting industry, writing for websites like RotoBaller and 4for4football. Frank is an active member of the fantasy baseball and fantasy football community, participating in high-stakes leagues like NFBC/NFFC as well as industry competitions like Scott Fish Bowl, RazzBowl, and TGFBI. Frank is a member of the FSWA and IBWAA. Give him a shout to talk fantasy sports and sports betting.

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