49ers vs Eagles Predictions & Odds

Frank AmmiranteSenior Sports Writer
Last Updated: Jan 30, 2023

The 49ers look to advance to the Super Bowl for the second time in the Kyle Shanahan era, heading to Philadelphia to take on the top-seeded Eagles.

Philly will try to get there for the second time since 2018, where they beat Tom Brady and the Patriots.

This is a game that features two of the most well-rounded rosters in the NFL. Both teams have elite weapons on offense with a defense capable of shutting down the opposition.

The difference here is that the Eagles have MVP candidate Jalen Hurts at quarterback, while the 49ers are starting Brock Purdy, a seventh-round rookie. While Purdy has done a great job considering the circumstances, he’s in for a tough test here.

With that in mind, let’s jump right into the San Francisco vs Philadelphia best bets for the NFC Championship Game.

49ers vs Eagles odds are courtesy of Caesars Sportsbook as of 12 p.m. ET, on Friday, Jan. 27.

49ers vs Eagles Odds

For NFC Championship odds, the Eagles come in as 2.5-point favorites, which makes sense given their advantages at quarterback and with home field.

The total sits at 46 points, baking in the risk that Purdy has some challenges with this Eagles’ pass defense, while also acknowledging that both of these teams can run the ball efficiently.

Each of these factors can keep this as a relatively low-scoring game.

Take a look at the best 49ers odds and Eagles odds for the 2022 NFL season.

49ers vs Eagles Implied Totals

Eagles 24.25, 49ers 21.75

Bookmakers are projecting a close game, but giving the edge to the Eagles because the game is in Philadelphia. If the 49ers were home here, they’d likely be favored by 2.5 points.

49ers vs Eagles Pick of the Day

Read more on this 49ers vs Eagles bet below.

49ers vs Eagles Prediction

Eagles 24, 49ers 20

This game comes down to Purdy against the Eagles’ pass defense. While the rookie has been great so far, we saw him have some challenges against the Cowboys (third in Pass DVOA per Football Outsiders).

Purdy completed 19-of-29 passes for 214 yards and managed the game by protecting the football, but he wasn’t able to move the ball efficiently like we’ve seen in previous weeks.

The 49ers were limited to only 19 points, which was their lowest since Week 12, when they defeated the Saints 13-0.

It doesn’t get easier against the Eagles, who rank first in Pass DVOA. They have limited opposing passers to only 6.31 yards per attempt, which is the best in the NFL.

In other words, this is Purdy’s toughest test of the season. We could see this go similar to the Cowboys game, except the Eagles have much more weapons on offense.

Find more 49ers vs Eagles betting plays

The 49ers will have to slow down the likes of A.J. Brown, DeVonta Smith, Dallas Goedert, and the top rushing offense in the NFL. That means that the best course of action would be to follow the Commanders’ blueprint in beating the Eagles back in Week 10.

In that game, Washington ran the ball 49 times, moving the chains for long drives. This kept the Eagles’ offense off the field, as the Commanders had over 40 minutes of possession.

If the 49ers can do that while limiting turnovers, they can pull off the upset here.

However, I’m betting on the best pass defense in the NFL doing just enough to slow down Purdy, helping to slow down this running game.

Look for the Eagles to win this one.

49ers vs Eagles Bet Tips

Here are a few 49ers vs Eagles betting trends to consider before making your bets:

  • The 49ers are 13-6 against the spread, and Overs are 10-9 in their games.
  • The Eagles are 9-9 ATS, and Overs have hit in 10 of their 18 games.
  • Purdy faces the best pass defense in the NFL.
  • Expect a run-heavy game plan from the 49ers.

49ers vs Eagles Best Bets

Eagles Moneyline (-145) at Caesars Sportsbook

WAGER: 1 Unit

I would always recommend taking a team on the spread when you’re getting them as 2.5-point favorites. This is because you’re below the key number of three and only need them to win by a field goal.

However, this is an exception because of the 49ers’ elite defense and running game.

There’s a chance that this game is decided on a last-minute field goal.

I don’t want to get burned by a missed extra point throwing off the score. At the same time, I’m confident that the Eagles will get it done at home.

I’ll drink the juice and take them on the moneyline to feel a bit more comfortable.

Want to bet on the Eagles? Check out the best PA sportsbooks!

Under 46 Total Points (-110) at Caesars Sportsbook

WAGER: 1 Unit

The 49ers are likely to run the ball at a high rate in this game, taking the pressure off their rookie quarterback as he deals with the top pass defense in the NFL. That bodes well for the Under, as it could result in longer drives.

I don’t envision this game turning into a shootout with how good the 49ers’ defense has played.

Want to bet on the 49ers? Check out the best U.S. sportsbooks!


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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