49ers vs Eagles Predictions & Best Bets

Last Updated: Nov 28, 2023

Highlighting the Week 13 slate on Sunday is an NFC Championship rematch between the Philadelphia Eagles and San Francisco 49ers in Philadelphia.

Philadelphia is an NFL-best 10-1 following its 37-34 comeback win in overtime against the Buffalo Bills. Meanwhile, San Francisco is on its heels at 8-3 after a 31-13 rout of the Seattle Seahawks on Thanksgiving.

A win would put the Eagles in the driver’s seat for home-field advantage in the NFC. But they’re in a rare spot as a home underdog.

Let’s look at what to expect from San Francisco-Philadelphia as we break down the NFL odds for Week 13.

49ers vs Eagles Odds

NFL odds used for this San Francisco vs Philadelphia preview were found at DraftKings Sportsbook and are current as of Nov. 27 at 5 p.m. ET.

  • Moneyline: 49ers (-148) • Eagles (+124)
  • Spread: 49ers -2.5 (-115) • Eagles +2.5 (-105)
  • Total Points: Over 47 (-110) • Under 47 (-110)
  • Implied Score: 49ers 24.75, Eagles 22.25

49ers vs Eagles Predictions

Score Pick: Eagles 27, 49ers 24

In four of their last five games, Philadelphia’s beaten a who’s who of top contenders with victories over the Miami Dolphins, Dallas Cowboys, Kansas City Chiefs, and Bills. While some may say they’re due for a letdown following their thrilling overtime comeback against Buffalo, the Eagles may be above that.

The Eagles have been especially tough at home, going 4-1 ATS and 5-0 straight up while averaging 32.8 points. Furthermore, Jalen Hurts has won 12 of his last 13 home starts during the regular season.

Lane Johnson‘s health is undoubtedly a concern. The All-Pro tackle was out Sunday with a groin injury and is considered day-to-day. He’ll be sorely needed against a dominant pass rush featuring the likes of Nick Bosa and Chase Young.

Regardless, I expect the Eagles to continue to impress in the comforts of home.

49ers vs Eagles Best Bets & Props

Eagles +2.5 (-105)

DraftKings Sportsbook • WAGER: 1.5 units

This is rare territory for Philadelphia. The Eagles are underdogs for only the second time this season and the first time at home since 2021.

The 49ers, winners of three straight, have been impressive in their own right. They’re one of two teams ranked in the top 5 in offense and defense. On top of that, they’re second in the NFL in point differential (plus-140).

Still, even though the 49ers are healthy again, getting the Eagles as home underdogs is too good to ignore. I’m taking them at +2.5 as my NFL bet of the day.

49ers -0.5 1H (-112)

DraftKings Sportsbook • WAGER: 1 unit

The Eagles have trailed at halftime in each of their last four games, including 17-7 deficits against both Kansas City and Buffalo. That obviously has not stopped Hurts, who continues to show a propensity for stepping up in the clutch. In fact, Sunday was Philadelphia’s record eighth consecutive victory when behind by double digits.

It’s easy to see the 49ers, backed by Christian McCaffrey, Deebo Samuel, and several other playmakers, putting the Eagles into another early hole. They’re well-rested following their win on Thanksgiving, not to mention healthy. That’ll be enough to cash in on this bet.

49ers Over 2.5 TDs (-160)

DraftKings Sportsbook • WAGER: 1 unit

The 49ers’ offense has been nearly unstoppable since the Week 9 bye, averaging 30.6 points over the last three weeks. That coincides with the return of Samuel and Trent Williams from injury.

They face a Philadelphia secondary that’s been susceptible to big plays. The Eagles have already given up 30-plus points three times and rank 19th in the league in average yards allowed (341 per game).

Based on that, anticipate a relatively high-scoring affair.

49ers vs Eagles Same Game Parlay

49ers vs Eagles SGP (+252)

DraftKings Sportsbook • WAGER: 1 unit

  • Eagles +3 (-118)
  • Over 46.5 (-110)
  • Eagles Over 24.5 (+154)

I’m hedging but still getting good value on the Eagles at +3.5. They’ve covered this bar every game this season except for a 20-14 loss to the Jets in Week 6.

As for the second leg, I’m siding with recent trends. Both teams have fared well against the Over, covering in six of their 11 games. They’re also both top 5 in scoring, averaging 28.2 points per game. If that continues, we’ll cash in here.


Doug Bonjour

Doug covered college and prep sports in Connecticut for more than a decade, including stints as the UConn women’s basketball and UConn football beat reporter for Hearst Connecticut Media. During his time reporting on the 11-time national champion Huskies, he covered three NCAA Final Fours. He also has written for the Associated Press and New York Times.

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