NFL Week 17 Parlays Picks & Predictions | NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Dec 28, 2021

It was another great week in parlay betting. We hit two of our parlays to win 10.1 units, which helped put us in the green for the season.

Let’s dive in to find my favorite parlay bets for Week 17 in the NFL pick of the day series.

Please note that all NFL gameday odds are courtesy of Caesars Sportsbook and are current as of 10:30 a.m. ET on Tuesday, December 28.

Best NFL Parlay Week 17

NFL Week 17 Top Parlay Picks

Wager: 2 Units To Win 11.92 Units (+596) at Caesars Sportsbook

  • Jacksonville Jaguars +15.5 Point Spread (-110) at New England Patriots
  • Chicago Bears -6 Point Spread (-110) vs New York Giants
  • Houston Texans +13 Point Spread (-110) at San Francisco 49ers

Jacksonville Jaguars +15.5 Point Spread (-110) at New England Patriots

The Jacksonville Jaguars (2-13) are one of the worst teams in football, set to take on the New England Patriots (9-6) in what is a total mismatch on paper.

The problem here is that it’s tough to lay over two touchdowns with a Patriots offense that is limited in firepower. Rookie quarterback Mac Jones only has 18 passing touchdowns while averaging 220.9 yards per game. This is a run-heavy offense led by Damien Harris.

Trevor Lawrence has shown a bit of improvement since Urban Meyer‘s firing, protecting the football and recording zero interceptions. While Jacksonville will be without star running back James Robinson, I’d bet on keeping this game within two touchdowns.

The Patriots aren’t good enough offensively to justify taking them with such a high point spread per our NFL gameday odds.

Sportsbook Play Of The Day

Before making your NFL Week 17 parlay picks, you should know that Caesars Sportsbook is one of the best around. Take advantage of Caesars’ outstanding welcome bonus which matches your first bet up to $1,001 (win or lose) when you use our promo code .

Check out Chris Wassel’s Caesars Sportsbook review for more information on this betting site, or continue reading for our Week 17 parlay predictions.

Chicago Bears -6 Point Spread (-110) vs New York Giants

The Chicago Bears are coming off a nice road win against the Seattle Seahawks. Quarterback Nick Foles threw for 250 yards and a touchdown. If Justin Fields is unable to return for this game, the Bears are in capable hands with Foles.

The real story here is the atrocious New York Giants offense. This team has combined for 102 points in their last eight games, which averages out to 12.75 points per game. The quarterback play has been horrendous, whether it’s been Mike Glennon or Jake Fromm under center.

The Bears should be able to run the ball effectively with David Montgomery, and their defense should have a field day against the worst offense in football right now.

Look for the Bears to win by a touchdown or more for their second consecutive win.

Houston Texans +13 Point Spread (-110) at San Francisco 49ers

One of the quietest stories in the NFL has been Houston Texans rookie quarterback Davis Mills. The third-rounder has thrown for 794 yards with five touchdowns and one interception in his last three games. Houston finally has competent quarterback play, which has led to a two-game winning streak.

The San Francisco 49ers are likely to start Trey Lance in this game, as Jimmy Garoppolo is currently dealing with a thumb injury. While I love Lance’s potential, I can’t help but think that there’s a chance that the offense struggles a bit with the change at quarterback.

The 49ers should be able to win this game, but 13 points is a high bar to clear.

Look for the Texans to keep this game close.

Davis Mills, QB, Houston Texans

Houston’s improved play as of late can be credited in part to Davis Mills, who has performed well in his last three starts. (Image: USA TODAY Sports)

NFL Week 17 Longshot Parlay Prediction

Wager: 2 Units To Win 14.82 Units (+741) at Caesars Sportsbook

  • Cincinnati Bengals Moneyline (+190) vs Kansas City Chiefs
  • Arizona Cardinals Moneyline (+190) at Dallas Cowboys

Cincinnati Bengals Moneyline (+190) vs Kansas City Chiefs

The Cincinnati Bengals are coming off an impressive blowout win over the division-rival Baltimore Ravens. Quarterback Joe Burrow was phenomenal, throwing for 525 yards and four touchdowns. The Bengals have a chance at a statement win against the hottest team in football.

The Kansas City Chiefs will likely get Travis Kelce back for this one. Their defense has been the real story during this eight-game winning streak, limiting opponents to 12.9 points per game.

Having said that, I think that we’ll see Burrow build off his dominant performance with another strong outing against Patrick Mahomes. This is a huge opportunity for the Bengals to cement their position as AFC North division winners.

Take the Bengals for the upset here.

Arizona Cardinals Moneyline (+190) at Dallas Cowboys

The Arizona Cardinals have hit a wall lately, losing three games in a row while averaging just 17 points per game. The offense has sputtered without star wideout DeAndre Hopkins.

Meanwhile, the Dallas Cowboys are absolutely rolling, winners of four straight, including a 56-14 obliteration of the division-rival Washington Football Team.

Here we have two teams headed in opposite directions. This is where we buy low.

The Cardinals desperately need a win to stay in the NFC West division race, while the Cowboys have already locked up the NFC East.

Ride with the Cardinals for a bounce-back win.

Same Game Parlay Picks NFL Week 17

Wager: 2 Units to win 3.94 Units (+197) at Caesars Sportsbook

  • Los Angeles Rams Moneyline & Total Points Over 46.5

It’s a shame to see the Baltimore Ravens’ season destroyed by injuries, but that’s where we are with this team. The defense is absolutely decimated, allowing 71 points in their last two games. Baltimore has now lost four in a row and is on the brink of elimination.

The Los Angeles Rams have won four in a row and now lead the NFC West. They have a chance to really pull away with the division with a win here.

I just don’t see how this depleted Ravens’ defense can slow down Matthew Stafford, Cooper Kupp, and a dominant Rams’ passing game.

Los Angeles should be able to win this game by a touchdown or more. They should also score enough points to push this total Over the number, especially with the Ravens’ deficiencies on defense, making this our NFL bet of the day.

Frank Ammirante’s 2021 NFL Parlay Betting Record: 8-43, +2.95 Units

Thanks for reading our NFL Week 17 Parlays Picks & Predictions! For more NFL Week 17 betting tips, check out our NFL bet of the day.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

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